We are analyzing https://link.springer.com/article/10.1007/s11064-008-9723-8.

Title:
Stem Cell Markers in Gliomas | Neurochemical Research
Description:
Gliomas are the most common tumours of the central nervous system (CNS) and a frequent cause of mental impairment and death. Treatment of malignant gliomas is often palliative because of their infiltrating nature and high recurrence. Genetic events that lead to brain tumours are mostly unknown. A growing body of evidence suggests that gliomas may rise from cancer stem cells (CSC) sharing with neural stem cells (NSC) the capacity of cell renewal and multipotency. Accordingly, a population of cells called “side population” (SP), which has been isolated from gliomas on the basis of their ability to extrude fluorescent dyes, behaves as stem cells and is resistant to chemotherapeutic treatments. This review will focus on the expression of the stem cell markers nestin and CD133 in glioma cancer stem cells. In addition, the possible role of Platelet Derived Growth Factor receptor type α (PDGFR-α) and Notch signalling in normal development and tumourigenesis of gliomas are also discussed. Future work elucidating the mechanisms that control normal development will help to identify new cancer stem cell-related genes. The identification of important markers and the elucidation of signalling pathways involved in survival, proliferation and differentiation of CSCs appear to be fundamental for developing an effective therapy of brain tumours.
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Keywords {🔍}

google, scholar, article, pubmed, cells, cas, stem, cancer, cell, neural, brain, adult, human, notch, res, expression, nestin, glioma, signalling, gliomas, growth, usa, cns, factor, glial, proc, natl, acad, sci, markers, nature, neurosci, mammalian, pdgf, tumors, development, glioblastoma, stemlike, research, proliferation, astrocytes, neuron, gene, plateletderived, privacy, cookies, content, population, genes, identification,

Topics {✒️}

platelet-derived growth factor-receptor platelet-derived growth factor month download article/chapter platelet-dependent serum factor anna maria giuffrida-stella article dell’albani stem cell markers paola dell’albani nerve growth factor central nervous system cell lines derived neural stem cells national research council full article pdf tumour stem cells neural progenitors cancer stem cell stem-cell origin glial characteristics radial glial identity human glioma cells adult glioblastoma multiforme cancer stem cells privacy choices/manage cookies cancerous stem cells glioma cell survival human glioblastoma multiforme mammalian epiblast differentiate cns stem cells cells expressing astroglial human glioma tissue notch pathway molecules subventricular germinal zone human tumor cells human neuroblastoma cells adult mammalian forebrain subtype-specific vulnerabilities related subjects vimentin intermediate filaments adult human hippocampus adult mammalian brain cell fate control adult human brain human brain tumors subventricular zone astrocytes glial cells granule cell precursors notch signalling activation bhlh gene hes1 bhlh gene hes5

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         description:Gliomas are the most common tumours of the central nervous system (CNS) and a frequent cause of mental impairment and death. Treatment of malignant gliomas is often palliative because of their infiltrating nature and high recurrence. Genetic events that lead to brain tumours are mostly unknown. A growing body of evidence suggests that gliomas may rise from cancer stem cells (CSC) sharing with neural stem cells (NSC) the capacity of cell renewal and multipotency. Accordingly, a population of cells called “side population” (SP), which has been isolated from gliomas on the basis of their ability to extrude fluorescent dyes, behaves as stem cells and is resistant to chemotherapeutic treatments. This review will focus on the expression of the stem cell markers nestin and CD133 in glioma cancer stem cells. In addition, the possible role of Platelet Derived Growth Factor receptor type α (PDGFR-α) and Notch signalling in normal development and tumourigenesis of gliomas are also discussed. Future work elucidating the mechanisms that control normal development will help to identify new cancer stem cell-related genes. The identification of important markers and the elucidation of signalling pathways involved in survival, proliferation and differentiation of CSCs appear to be fundamental for developing an effective therapy of brain tumours.
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