We are analyzing https://link.springer.com/article/10.1007/s11064-008-9696-7.

Title:
Benefits from Dietary Polyphenols for Brain Aging and Alzheimer’s Disease | Neurochemical Research
Description:
Brain aging and the most diffused neurodegenerative diseases of the elderly are characterized by oxidative damage, redox metals homeostasis impairment and inflammation. Food polyphenols can counteract these alterations in vitro and are therefore suggested to have potential anti-aging and brain-protective activities, as also indicated by the results of some epidemiological studies. Despite the huge and increasing amount of the in vitro studies trying to unravel the mechanisms of action of dietary polyphenols, the research in this field is still incomplete, and questions about bioavailability, biotransformation, synergism with other dietary factors, mechanisms of the antioxidant activity, risks inherent to their possible pro-oxidant activities are still unanswered. Most of all, the capacity of the majority of these compounds to cross the blood–brain barrier and reach brain is still unknown. This commentary discusses recent data on these aspects, particularly focusing on effects of curcumin, resveratrol and catechins on Alzheimer’s disease.
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Keywords {🔍}

google, scholar, pubmed, article, cas, disease, alzheimers, brain, aging, biol, copper, oxidative, neurosci, polyphenols, protein, free, res, stress, med, dietary, amyloid, cell, rossi, neurol, radic, iron, nutr, chem, research, neurodegenerative, neurochem, biochem, tea, damage, antioxidant, curcumin, resveratrol, access, cognitive, role, pharmacol, green, study, alzheimer, privacy, cookies, content, diseases, potential, activity,

Topics {✒️}

epigallocatechin-3-gallate-induced alpha-secretase cleavage month download article/chapter 4-hydroxy-2-trans-nonenal il-1β ethanol-induced cell death beta-amyloid-induced neurotoxicity p53-mediated cell death nitric oxide-related toxicity anna maria giuffrida-stella oxidative stress-induced degeneration widespread peroxynitrite-mediated damage ethanol-induced brain damage aged blueberry-fed rats disease amyloid-beta peptides disease amyloid-beta opposes green tea epigallocatechin-3-gallate cu-dependent catalytic conversion potent anti-amyloidogenic effects full article pdf nuclear factor kappa related subjects amyloid precursor protein natural iron chelators-antioxidants n-methyl-4-phenyl-1 degenerative neurological disorders author information authors age-dependent elevations privacy choices/manage cookies csf [beta]-amyloid amyloid beta-peptide beta-amyloid binds cross-national dementia study reactive oxygen species red wine constituents abellan van kan β-secretase bbb amyloid-beta deposition beta-amyloid fibrils epigallocatechin-3-gallate fad reactive oxygen intermediates potent anti-amyloidogenic human neuroblastoma cells blood–brain barrier diffused neurodegenerative diseases combat oxidative stress interleukin-1β inos reduces cerebral amyloidosis superoxide dismutase mimics quasi-physiological conditions redox-activated forms neuroprotection versus neurotoxicity

Questions {❓}

Giorgio M, Trinei M, Migliaccio E, Pelicci G (2007) Hydrogen peroxide: a metabolic by-product or a common mediator of aging signals?

Schema {🗺️}

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         description:Brain aging and the most diffused neurodegenerative diseases of the elderly are characterized by oxidative damage, redox metals homeostasis impairment and inflammation. Food polyphenols can counteract these alterations in vitro and are therefore suggested to have potential anti-aging and brain-protective activities, as also indicated by the results of some epidemiological studies. Despite the huge and increasing amount of the in vitro studies trying to unravel the mechanisms of action of dietary polyphenols, the research in this field is still incomplete, and questions about bioavailability, biotransformation, synergism with other dietary factors, mechanisms of the antioxidant activity, risks inherent to their possible pro-oxidant activities are still unanswered. Most of all, the capacity of the majority of these compounds to cross the blood–brain barrier and reach brain is still unknown. This commentary discusses recent data on these aspects, particularly focusing on effects of curcumin, resveratrol and catechins on Alzheimer’s disease.
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