We are analyzing https://link.springer.com/article/10.1007/s11064-007-9426-6.

Title:
Umbilical Cord Blood Stem Cell Mediated Downregulation of Fas Improves Functional Recovery of Rats after Spinal Cord Injury | Neurochemical Research
Description:
Human umbilical cord blood stem cells (hUCB), due to their primitive nature and ability to develop into nonhematopoietic cells of various tissue lineages, represent a potentially useful source for cell-based therapies after spinal cord injury (SCI). To evaluate their therapeutic potential, hUCB were stereotactically transplanted into the injury epicenter, one week after SCI in rats. Our results show the presence of a substantial number of surviving hUCB in the injured spinal cord up to five weeks after transplantation. Three weeks after SCI, apoptotic cells were found especially in the dorsal white matter and gray matter, which are positive for both neuron and oligodendrocyte markers. Expression of Fas on both neurons and oligodendrocytes was efficiently downregulated by hUCB. This ultimately resulted in downregulation of caspase-3 extrinsic pathway proteins involving increased expression of FLIP, XIAP and inhibition of PARP cleavage. In hUCB-treated rats, the PI3K/Akt pathway was also involved in antiapoptotic actions. Further, structural integrity of the cytoskeletal proteins α-tubulin, MAP2A&2B and NF-200 has been preserved in hUCB treatments. The behavioral scores of hind limbs of hUCB-treated rats improved significantly than those of the injured group, showing functional recovery. Taken together, our results indicate that hUCB-mediated downregulation of Fas and caspases leads to functional recovery of hind limbs of rats after SCI.
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Keywords {🔍}

cord, spinal, article, google, scholar, pubmed, cas, injury, cells, stem, apoptosis, rats, recovery, umbilical, cell, rat, fas, functional, neurosci, death, neurol, blood, human, caspase, springer, traumatic, exp, sci, factor, growth, res, function, research, hucb, brain, protein, peoria, privacy, cookies, content, improves, apoptotic, expression, access, degeneration, usa, publish, search, downregulation, jasti,

Topics {✒️}

month download article/chapter brain-derived neutrophic factor liang li & jasti cytoskeletal proteins α-tubulin calpain-dependent neurofilament breakdown hucb-mediated downregulation liang li spinal cord injury improves functional recovery cancer biology improves neurological function showing functional recovery fas-mediated apoptosis rat spinal cord apoptotic cell death injured spinal cord neuronal cell death spinal cord contusion spinal cord transplantation cell-based therapies cell therapy approaches spinal cord injuries spinal cord ischemia full article pdf apoptotic cells author information authors fas signaling mechanisms nonhematopoietic cells promotes oligodendroglial survival enhances axonal survival functional recovery privacy choices/manage cookies caspase-3 apoptotic cascade severe contusion injury pi3k/akt pathway open field testing article dasari spinal cord 43 spinal cord 36 related subjects x-linked inhibitor axotomy-induced death author correspondence map2a&2b dorsal white matter check access instant access nottingham sa fas antigen induction locomotor recovery

Schema {🗺️}

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         description:Human umbilical cord blood stem cells (hUCB), due to their primitive nature and ability to develop into nonhematopoietic cells of various tissue lineages, represent a potentially useful source for cell-based therapies after spinal cord injury (SCI). To evaluate their therapeutic potential, hUCB were stereotactically transplanted into the injury epicenter, one week after SCI in rats. Our results show the presence of a substantial number of surviving hUCB in the injured spinal cord up to five weeks after transplantation. Three weeks after SCI, apoptotic cells were found especially in the dorsal white matter and gray matter, which are positive for both neuron and oligodendrocyte markers. Expression of Fas on both neurons and oligodendrocytes was efficiently downregulated by hUCB. This ultimately resulted in downregulation of caspase-3 extrinsic pathway proteins involving increased expression of FLIP, XIAP and inhibition of PARP cleavage. In hUCB-treated rats, the PI3K/Akt pathway was also involved in antiapoptotic actions. Further, structural integrity of the cytoskeletal proteins α-tubulin, MAP2A&2B and NF-200 has been preserved in hUCB treatments. The behavioral scores of hind limbs of hUCB-treated rats improved significantly than those of the injured group, showing functional recovery. Taken together, our results indicate that hUCB-mediated downregulation of Fas and caspases leads to functional recovery of hind limbs of rats after SCI.
         datePublished:2007-08-17T00:00:00Z
         dateModified:2007-08-17T00:00:00Z
         pageStart:134
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            Apoptosis
            Fas
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            Biochemistry
            general
            Cell Biology
            Neurology
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      headline:Umbilical Cord Blood Stem Cell Mediated Downregulation of Fas Improves Functional Recovery of Rats after Spinal Cord Injury
      description:Human umbilical cord blood stem cells (hUCB), due to their primitive nature and ability to develop into nonhematopoietic cells of various tissue lineages, represent a potentially useful source for cell-based therapies after spinal cord injury (SCI). To evaluate their therapeutic potential, hUCB were stereotactically transplanted into the injury epicenter, one week after SCI in rats. Our results show the presence of a substantial number of surviving hUCB in the injured spinal cord up to five weeks after transplantation. Three weeks after SCI, apoptotic cells were found especially in the dorsal white matter and gray matter, which are positive for both neuron and oligodendrocyte markers. Expression of Fas on both neurons and oligodendrocytes was efficiently downregulated by hUCB. This ultimately resulted in downregulation of caspase-3 extrinsic pathway proteins involving increased expression of FLIP, XIAP and inhibition of PARP cleavage. In hUCB-treated rats, the PI3K/Akt pathway was also involved in antiapoptotic actions. Further, structural integrity of the cytoskeletal proteins α-tubulin, MAP2A&2B and NF-200 has been preserved in hUCB treatments. The behavioral scores of hind limbs of hUCB-treated rats improved significantly than those of the injured group, showing functional recovery. Taken together, our results indicate that hUCB-mediated downregulation of Fas and caspases leads to functional recovery of hind limbs of rats after SCI.
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      dateModified:2007-08-17T00:00:00Z
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         Umbilical cord blood stem cells
         Apoptosis
         Fas
         Caspase-3
         Spinal cord Injury
         Functional recovery
         Neurosciences
         Neurochemistry
         Biochemistry
         general
         Cell Biology
         Neurology
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