We are analyzing https://link.springer.com/article/10.1007/s11064-006-9254-0.

Title:
Mitochondrial OXPHOS Functions in R1H Rhabdomyosarcoma and Skeletal Muscles of the Rat | Neurochemical Research
Description:
The aim of the study was to determinate mitochondrial oxidative phosphorylation (OXPHOS) functions in rat rhabdomyosarcoma R1H (R1H) and rat skeletal muscles. For that purpose skinned fiber technique and multiple substrate inhibitor titration were adapted to tumor samples. In our animal tumor model (R1H) functional abnormalities of OXPHOS were found compared to skeletal muscles. In R1H the state 3 respiration of pyruvate + malate was decreased: 0.56 ± 0.28 nmol O2/mg/min versus 2.32 ± 1.19 nmol O2/mg/min, P < 0.001, whereas the state 3 respiration of succinate + rotenone was increased: 36 ± 14% versus 19 ± 11%, P < 0.001. In R1H the rotenone-insensitive respiration reached higher levels than the antimycin A-insensitive respiration, whereas in normal muscles the converse was observed. Additionally, the obvious difference between the CAT- and the antimycin A-independent respiration indicates an increased part of leak respiration in R1H. By now, the high feasibility of these techniques is appreciated for the investigation of muscles and prospectively for tumors, too.
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Keywords {🔍}

google, scholar, article, pubmed, cas, mitochondrial, cancer, respiration, respiratory, rat, res, muscle, cell, rhabdomyosarcoma, skeletal, oxidative, human, tumor, mitochondria, cells, biochem, content, research, oxphos, muscles, gellerich, phosphorylation, access, complex, biol, privacy, cookies, functions, kuhnt, pyruvate, metabolism, chain, biophys, acta, studies, mol, fibers, publish, search, thomas, succinate, tumors, biochim, germany, function,

Topics {✒️}

high resolution respirometry 28 nmol o2/mg/min versus 2 otto-von-guericke-university magdeburg month download article/chapter martin-luther-universität halle-wittenberg 19 nmol o2/mg/min saponin-skinned fibers mitochondrial oxphos functions von hippel-lindau disease antimycin a-insensitive respiration rat liver mitochondria mitochondrial dna-encoded subunits antimycin a-independent respiration permeabilized muscle fibers rat rhabdomyosarcoma r1h full article pdf electron transfer system related subjects privacy choices/manage cookies rat skeletal muscles richard cw 3rd martin-luther-university check access instant access rhabdomyosarcoma tumor cells mitochondrial oxidative phosphorylation mitochondrial respiratory parameters high feasibility renal cell carcinoma modulating metabolism mitochondrial dna damage mitochondrial membrane potential respiratory nadh dehydrogenase human cell line skeletal muscle van der mey p53-independent proliferation cell population kinetics human colorectal tumours malignant human gliomas mitochondrial genome instability mitochondrial respiratory function mitochondrial respiratory rates article kuhnt mitochondrial myopathy studies european economic area septic icu patients hif−1alpha regulation willett-brozick je beck-bornholdt hp

Questions {❓}

Hobermann HD (1975) Is there a role for mitochondrial genes in carcinogenesis?

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         description:The aim of the study was to determinate mitochondrial oxidative phosphorylation (OXPHOS) functions in rat rhabdomyosarcoma R1H (R1H) and rat skeletal muscles. For that purpose skinned fiber technique and multiple substrate inhibitor titration were adapted to tumor samples. In our animal tumor model (R1H) functional abnormalities of OXPHOS were found compared to skeletal muscles. In R1H the state 3 respiration of pyruvate + malate was decreased: 0.56 ± 0.28 nmol O2/mg/min versus 2.32 ± 1.19 nmol O2/mg/min, P < 0.001, whereas the state 3 respiration of succinate + rotenone was increased: 36 ± 14% versus 19 ± 11%, P < 0.001. In R1H the rotenone-insensitive respiration reached higher levels than the antimycin A-insensitive respiration, whereas in normal muscles the converse was observed. Additionally, the obvious difference between the CAT- and the antimycin A-independent respiration indicates an increased part of leak respiration in R1H. By now, the high feasibility of these techniques is appreciated for the investigation of muscles and prospectively for tumors, too.
         datePublished:2007-02-02T00:00:00Z
         dateModified:2007-02-02T00:00:00Z
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      headline:Mitochondrial OXPHOS Functions in R1H Rhabdomyosarcoma and Skeletal Muscles of the Rat
      description:The aim of the study was to determinate mitochondrial oxidative phosphorylation (OXPHOS) functions in rat rhabdomyosarcoma R1H (R1H) and rat skeletal muscles. For that purpose skinned fiber technique and multiple substrate inhibitor titration were adapted to tumor samples. In our animal tumor model (R1H) functional abnormalities of OXPHOS were found compared to skeletal muscles. In R1H the state 3 respiration of pyruvate + malate was decreased: 0.56 ± 0.28 nmol O2/mg/min versus 2.32 ± 1.19 nmol O2/mg/min, P < 0.001, whereas the state 3 respiration of succinate + rotenone was increased: 36 ± 14% versus 19 ± 11%, P < 0.001. In R1H the rotenone-insensitive respiration reached higher levels than the antimycin A-insensitive respiration, whereas in normal muscles the converse was observed. Additionally, the obvious difference between the CAT- and the antimycin A-independent respiration indicates an increased part of leak respiration in R1H. By now, the high feasibility of these techniques is appreciated for the investigation of muscles and prospectively for tumors, too.
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      dateModified:2007-02-02T00:00:00Z
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         OXPHOS functions
         Skinned fiber technique
         High-resolution respirometry
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         Neurochemistry
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         Neurology
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