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Title:
Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG | Journal of Neuro-Oncology
Description:
Diffuse intrinsic pontine glioma (DIPG) nearly exclusively affects children. The prognosis of DIPGs has remained grim despite more than three decades of clinical research and numerous clinical trials. More than 90% of the children with DIPG will succumb within 2 years of diagnosis. The tumorās incidence is still undefined, but data suggest 100ā150 affected children annually in the US. The single proven effective treatment modality in DIPG remains radiation therapy. For the majority of patients however this treatment is only of transient effectiveness. Recent breakthroughs in the understanding of the molecular biology of DIPG have raised new hope and opened new avenues for therapeutic options. The advancement of basic and translational research and cooperation was the objective of the Toronto Think Tank, as new approaches are urgently needed.
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Keywords {š}
article, google, scholar, pubmed, cas, children, cancer, study, glioma, brain, oncol, diffuse, pediatric, phase, intrinsic, gliomas, pontine, brainstem, kun, radiotherapy, tumors, group, stem, boyett, childrens, research, dipg, bouffet, treatment, radiation, oncology, clin, bartels, trial, packer, neuro, geyer, toronto, therapy, paediatric, hyperfractionated, newly, diagnosed, pollack, broniscer, stewart, poussaint, tumor, blaney, clinical,
Topics {āļø}
month download article/chapter paediatric pontine glioma medulloblastoma/primitive neuroectodermal tumor relapsing/refractory brain tumors progressive high-grade glioma diffuse pontine gliomas newly diagnosed brainstem brain stem gliomas pediatric oncology group brain-stem glioma diffuse brainstem glioma brain stem tumors full article pdf refractory brain tumors childhood brain tumours cancer pediatric phase cancer study group national medical center privacy choices/manage cookies oncology group study united kingdom children diagnostic imaging neurological surgery recurrent brain tumors supratentorial malignant gliomas paediatric patients refractory solid tumors recurrent malignant gliomas van lindert ej fractionated stereotactic radiotherapy recurrent malignant glioma small molecule inhibitor farnesyl transferase inhibitor neuro-oncology aims interstitial radiation therapy european economic area long term survivors schouten-meeteren ay schulz-ertner treat patient population cis-retinoic acid high dose busulfan post mortem examinations weill medical college phase ii study article journal numerous clinical trials conditions privacy policy treatment related toxicities nervous system
Questions {ā}
- Chastagner P, Bouffet E, Grill J, Kalifa C (2001) What have we learnt from previous phase II trials to help in the management of childhood brain tumours?
- Pediatric diffuse intrinsic pontine glioma: where do we stand?
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headline:Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG
description:Diffuse intrinsic pontine glioma (DIPG) nearly exclusively affects children. The prognosis of DIPGs has remained grim despite more than three decades of clinical research and numerous clinical trials. More than 90% of the children with DIPG will succumb within 2Ā years of diagnosis. The tumorās incidence is still undefined, but data suggest 100ā150 affected children annually in the US. The single proven effective treatment modality in DIPG remains radiation therapy. For the majority of patients however this treatment is only of transient effectiveness. Recent breakthroughs in the understanding of the molecular biology of DIPG have raised new hope and opened new avenues for therapeutic options. The advancement of basic and translational research and cooperation was the objective of the Toronto Think Tank, as new approaches are urgently needed.
datePublished:2011-09-08T00:00:00Z
dateModified:2011-09-08T00:00:00Z
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DIPG
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Oncology
Neurology
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description:Diffuse intrinsic pontine glioma (DIPG) nearly exclusively affects children. The prognosis of DIPGs has remained grim despite more than three decades of clinical research and numerous clinical trials. More than 90% of the children with DIPG will succumb within 2Ā years of diagnosis. The tumorās incidence is still undefined, but data suggest 100ā150 affected children annually in the US. The single proven effective treatment modality in DIPG remains radiation therapy. For the majority of patients however this treatment is only of transient effectiveness. Recent breakthroughs in the understanding of the molecular biology of DIPG have raised new hope and opened new avenues for therapeutic options. The advancement of basic and translational research and cooperation was the objective of the Toronto Think Tank, as new approaches are urgently needed.
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