Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s11033-012-2397-y.

Title:
New insights to the ubiquitin–proteasome pathway (UPP) mechanism during spermatogenesis | Molecular Biology Reports
Description:
Spermatogenesis is a complicated and highly ordered process which begins with the differentiation of spermatogonial stem cells and ends with the formation of mature sperm. After meiosis, several morphological changes occur during spermatogenesis. During spermatogenesis, many proteins and organelles are degraded, and the ubiquitin–proteasome pathway (UPP) plays a key role in the process which facilitates the formation of condensed sperm. UPP contains various indispensable components: ubiquitin, ubiquitin-activating enzyme E1, ubiquitin-conjugating enzyme E2, ubiquitin ligase enzyme E3 and proteasomes. At some key stages of spermatogenesis, such as meiosis, acrosome biogenesis, and spermatozoa maturation, the ubiquitin-related components (including deubiquitination enzymes) exert positive and active functions. Generally speaking, deficient UPP will block spermatogenesis which may induce infertility at various degrees. Although ubiquitination during spermatogenesis has been widely investigated, further detailed aspects such as the mechanism of ubiquitination during the formation of midpiece and acrosome morphogenesis still remains unknown. The present review will overview current progress on ubiquitination during spermatogenesis, and will provide some suggestions for future studies on the functions of UPP components during spermatogenesis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

google, scholar, pubmed, article, cas, ubiquitin, biol, cell, spermatogenesis, ligase, protein, reprod, sperm, mol, dev, ubiquitination, mitochondrial, sutovsky, rat, mouse, cancer, enzyme, rev, role, chen, zhang, expression, cells, testis, kim, acrosome, res, dna, system, biochem, sci, regulation, mitochondria, wing, liu, proteins, ubiquitinconjugating, nature, mammalian, histone, hum, lee, human, cterminal, gene,

Topics {✒️}

ubiquitin carboxyl-terminal hydrolase-l1 ubiquitin c-terminal hydrolase-l1 ubiquitin ligase scf{beta}-trcp /lasu1/mule/arf-bp1/huwe1 testis-specific ubiquitin-conjugating enzyme ubiquitin-activating enzyme e1-domain month download article/chapter cullin-based ubiquitin ligases bh3-ligand regulates access wan-xi yang ubiquitin-activating enzyme e1 ubiquitin-dependent protein degradation ngf-deprived sympathetic neurons dual ubiquitin-tunel assay rnf8-dependent histone ubiquitination ubiquitin-mediated degradation ubiquitin-conjugating enzyme e2 ubiquitin-dependent protein sorting testis-specific endoplasmic reticulum membrane-bound ubiquitin ligase phosphorylation-dependent ubiquitination cul3-btb complexes join gradient-purified semen samples ubiquitin-based sperm assay cyclic amp-induced transcription membrane/voltage-gated channels escape gsk3-dependent recognition v-jun point mutation ubiquitin-protein ligase system spermatogenesis-related gene ube1 head-tail coupling apparatus ubiquitin ligase fbw7 fbw7 ubiquitin ligase arf tumor suppressor y-chromosomal gene usp9y gtp-binding protein involved scffbw7 ubiquitin ligase male-specific sterility defect ubiquitin conjugating enzymes article hou ubiquitin-conjugating enzyme e3 ubiquitin ligase ubiquitin ligase e3 ubiquitin-proteasome proteolytic pathway transforming growth factor-beta full article pdf ubc4-dependent pathway e1 enzyme specific ring finger domain tumor suppressor p53

Questions {❓}

  • Spiropoulos J, Turnbull DM, Chinnery PF (2002) Can mitochondrial DNA mutations cause sperm dysfunction?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:New insights to the ubiquitin–proteasome pathway (UPP) mechanism during spermatogenesis
         description:Spermatogenesis is a complicated and highly ordered process which begins with the differentiation of spermatogonial stem cells and ends with the formation of mature sperm. After meiosis, several morphological changes occur during spermatogenesis. During spermatogenesis, many proteins and organelles are degraded, and the ubiquitin–proteasome pathway (UPP) plays a key role in the process which facilitates the formation of condensed sperm. UPP contains various indispensable components: ubiquitin, ubiquitin-activating enzyme E1, ubiquitin-conjugating enzyme E2, ubiquitin ligase enzyme E3 and proteasomes. At some key stages of spermatogenesis, such as meiosis, acrosome biogenesis, and spermatozoa maturation, the ubiquitin-related components (including deubiquitination enzymes) exert positive and active functions. Generally speaking, deficient UPP will block spermatogenesis which may induce infertility at various degrees. Although ubiquitination during spermatogenesis has been widely investigated, further detailed aspects such as the mechanism of ubiquitination during the formation of midpiece and acrosome morphogenesis still remains unknown. The present review will overview current progress on ubiquitination during spermatogenesis, and will provide some suggestions for future studies on the functions of UPP components during spermatogenesis.
         datePublished:2012-12-26T00:00:00Z
         dateModified:2012-12-26T00:00:00Z
         pageStart:3213
         pageEnd:3230
         sameAs:https://doi.org/10.1007/s11033-012-2397-y
         keywords:
            Ubiquitin
            Ubiquitination
            Spermatogenesis
            Mitochondria
            Acrosome
            Midpiece
            Animal Biochemistry
            Animal Anatomy / Morphology / Histology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig4_HTML.gif
         isPartOf:
            name:Molecular Biology Reports
            issn:
               1573-4978
               0301-4851
            volumeNumber:40
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Cong-Cong Hou
               affiliation:
                     name:Zhejiang University
                     address:
                        name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wan-Xi Yang
               affiliation:
                     name:Zhejiang University
                     address:
                        name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:New insights to the ubiquitin–proteasome pathway (UPP) mechanism during spermatogenesis
      description:Spermatogenesis is a complicated and highly ordered process which begins with the differentiation of spermatogonial stem cells and ends with the formation of mature sperm. After meiosis, several morphological changes occur during spermatogenesis. During spermatogenesis, many proteins and organelles are degraded, and the ubiquitin–proteasome pathway (UPP) plays a key role in the process which facilitates the formation of condensed sperm. UPP contains various indispensable components: ubiquitin, ubiquitin-activating enzyme E1, ubiquitin-conjugating enzyme E2, ubiquitin ligase enzyme E3 and proteasomes. At some key stages of spermatogenesis, such as meiosis, acrosome biogenesis, and spermatozoa maturation, the ubiquitin-related components (including deubiquitination enzymes) exert positive and active functions. Generally speaking, deficient UPP will block spermatogenesis which may induce infertility at various degrees. Although ubiquitination during spermatogenesis has been widely investigated, further detailed aspects such as the mechanism of ubiquitination during the formation of midpiece and acrosome morphogenesis still remains unknown. The present review will overview current progress on ubiquitination during spermatogenesis, and will provide some suggestions for future studies on the functions of UPP components during spermatogenesis.
      datePublished:2012-12-26T00:00:00Z
      dateModified:2012-12-26T00:00:00Z
      pageStart:3213
      pageEnd:3230
      sameAs:https://doi.org/10.1007/s11033-012-2397-y
      keywords:
         Ubiquitin
         Ubiquitination
         Spermatogenesis
         Mitochondria
         Acrosome
         Midpiece
         Animal Biochemistry
         Animal Anatomy / Morphology / Histology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2397-y/MediaObjects/11033_2012_2397_Fig4_HTML.gif
      isPartOf:
         name:Molecular Biology Reports
         issn:
            1573-4978
            0301-4851
         volumeNumber:40
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Cong-Cong Hou
            affiliation:
                  name:Zhejiang University
                  address:
                     name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wan-Xi Yang
            affiliation:
                  name:Zhejiang University
                  address:
                     name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Molecular Biology Reports
      issn:
         1573-4978
         0301-4851
      volumeNumber:40
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Zhejiang University
      address:
         name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Zhejiang University
      address:
         name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Cong-Cong Hou
      affiliation:
            name:Zhejiang University
            address:
               name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Wan-Xi Yang
      affiliation:
            name:Zhejiang University
            address:
               name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
      name:The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(490)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

5.32s.