We are analyzing https://link.springer.com/article/10.1007/s11033-012-1760-3.

Title:
Cancer chemotherapy reduces plasma total polyphenols and total antioxidants capacity in colorectal cancer patients | Molecular Biology Reports
Description:
Our aim was to investigate the effect of chemotherapy on plasma total antioxidant capacity and polyphenols in patients with colon cancer. Plasma samples were collected from 70 CRC patients under chemotherapy treatment, and 15 non-treated patients. The control group included 71 healthy individuals. Plasma ABTS and FRAP were measured as biomarkers of antioxidant total capacity and the total phenols as an indicator to determine the polyphenols levels in plasma. Treatment with chemotherapy protocols resulted in a significant decrease of ABTS (−24 %, p < 0.048), FRAP (−15 %, p < 0.046) and polyphenols (−46 %, p < 0.05) compared with the values of those not treated. The total antioxidant capacity was significantly lower (−18 % for ABTS and −12 % for FRAP) in patients with metastasis as compared with patients without metastasis. The plasma total phenols, were also decreased (−16 %, p = 0.005) in metastasis patients. The patients with colorectal cancer have decreased total antioxidant capacity and the values are lower in patients treated with chemotherapy. Furthermore, CEA tumor marker levels are associated with a lower plasma total antioxidant capacity, and therefore with the progress and development of the disease.
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Keywords {🔍}

cancer, article, google, scholar, pubmed, cas, patients, chemotherapy, total, colorectal, plasma, antioxidant, colon, nutr, res, capacity, access, privacy, cookies, content, polyphenols, antioxidants, frap, oxidative, biol, burgos, publish, research, search, molecular, santiagoarteche, abts, mol, free, biochem, human, cell, data, information, log, journal, muñiz, caviasaiz, garcíagonzalez, treatment, phenols, lower, metastasis, cea, tumor,

Topics {✒️}

month download article/chapter garcía-gonzalez & beatriz llorente-ayala cisplatin-induced superoxide anion bueno-de-mesquita hb oxidative stress-induced cancer hospital general yagüe plasma total phenols antioxidant total capacity total antioxidant capacity thioredoxin system inhibitors full article pdf beatriz llorente-ayala related subjects metastatic colorectal cancer van gils ch avenida del cid cell-free system privacy choices/manage cookies antioxidant activity applying cancer research carcinoembryonic antigen surge ramirez-tortosa cl author information authors oxaliplatin combination chemotherapy ramirez-tortosa mc total antioxidants capacity article santiago-arteche colorectal cancer patients colorectal cancer risk european economic area chemotherapy protocols resulted tumor marker monitoring enhanced oxidative stress breast cancer patients total phenols sporadic colorectal tumors case-control studies junta de castilla controlling tumor growth oxaliplatin combination therapy scope submit manuscript ferric reducing ability normal physiological functions european prospective investigation reactive oxygen species modulating endogenous production da rocha ab universidad de burgos conditions privacy policy boutron-ruault mc

Questions {❓}

Chen CC, Yang SH, Lin JK, Lin TC, Chen WS, Jiang JK, Wang HS, Chang SC (2005) Is it reasonable to add preoperative serum level of CEA and CA19-9 to staging for colorectal cancer?
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation, and cancer: how are they linked?
Vera-Ramirez L, Sanchez-Rovira P, Ramirez-Tortosa MC, Ramirez-Tortosa CL, Granados-Principal S, Fernandez-Navarro M, Lorente JA, Quiles JL (2011) Does chemotherapy-induced oxidative stress improve the survival rates of breast cancer patients?

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         description:Our aim was to investigate the effect of chemotherapy on plasma total antioxidant capacity and polyphenols in patients with colon cancer. Plasma samples were collected from 70 CRC patients under chemotherapy treatment, and 15 non-treated patients. The control group included 71 healthy individuals. Plasma ABTS and FRAP were measured as biomarkers of antioxidant total capacity and the total phenols as an indicator to determine the polyphenols levels in plasma. Treatment with chemotherapy protocols resulted in a significant decrease of ABTS (−24 %, p < 0.048), FRAP (−15 %, p < 0.046) and polyphenols (−46 %, p < 0.05) compared with the values of those not treated. The total antioxidant capacity was significantly lower (−18 % for ABTS and −12 % for FRAP) in patients with metastasis as compared with patients without metastasis. The plasma total phenols, were also decreased (−16 %, p = 0.005) in metastasis patients. The patients with colorectal cancer have decreased total antioxidant capacity and the values are lower in patients treated with chemotherapy. Furthermore, CEA tumor marker levels are associated with a lower plasma total antioxidant capacity, and therefore with the progress and development of the disease.
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