We are analyzing https://link.springer.com/article/10.1007/s11010-017-3170-2.

Title:
USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN | Molecular and Cellular Biochemistry
Description:
To determine the potential tumor suppressor functions of ubiquitin-specific protease 10 (USP10) in lung cancer and elucidate underlying molecular mechanism. The relative expression of USP10 was determined by real-time PCR and immunoblotting. The inhibitory effect of USP10 on tumor growth was demonstrated on allograft mice with Lewis carcinoma cell inoculation. The relative cell proliferation was measured with Cell Counting Kit-8 (CCK-8). The invasive capacity was evaluated by transwell assay. The interaction between USP10 and Phosphatase And Tensin Homolog (PTEN) was examined by co-immunoprecipitation. Ubiquitination/deubiquitination was analyzed by immunoprecipitation followed by immunoblotting. USP10 was down-regulated in lung cancer. Knockdown of USP10 promotes tumor growth and invasion both in vitro and in vivo. We further demonstrated that USP10 directly interacted with and stabilized PTEN via deubiquitination. The pro-cancerous effect of USP10 deficiency was abolished by re-introduction of PTEN. We suggested a tumor suppressor function of USP10 in lung cancer via deubiquitinating and stabilizing PTEN.
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Keywords {🔍}

article, pubmed, usp, google, scholar, cancer, cas, cell, pten, lung, central, tumor, access, privacy, cookies, content, research, invasion, sun, publish, search, growth, suppressor, ubiquitinspecific, promotes, deubiquitination, regulating, regulates, stability, stabilization, biol, function, consent, data, standards, information, log, journal, molecular, cellular, august, zhao, xiufeng, jiang, functions, effect, deubiquitinating, open, discover, res,

Topics {✒️}

pten/pi3k/akt signalling pathway month download article/chapter hui wu & xiufeng jiang proto-oncogenic ubiquitin ligase ubiquitin-specific protease 10 cellular biochemistry aims relative cell proliferation full article pdf lung cancer epidemiology ubiquitin-specific proteases ubiquitin-specific peptidase 10 privacy choices/manage cookies related subjects regulate cellular sensitivity cell counting kit-8 article molecular cancer predisposing syndromes barnaby rl pi3-kinase pathway proteins involved lung cancer lung cancer 2015 national research committee inflammatory cell migration regulating pten phosphorylation individual participants included article sun usp10 directly interacted tumor suppressor function european economic area real-time pcr airway epithelial cells histone variant h2a nanjing medical university ethics declarations conflicts article log cancer cell 15 conditions privacy policy xiufeng jiang suppress tumor formation relative expression tumour biol 35 upregulating pten published check access instant access accepting optional cookies pro-cancerous effect radiol clin north article cite tumor growth

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         headline:USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN
         description:To determine the potential tumor suppressor functions of ubiquitin-specific protease 10 (USP10) in lung cancer and elucidate underlying molecular mechanism. The relative expression of USP10 was determined by real-time PCR and immunoblotting. The inhibitory effect of USP10 on tumor growth was demonstrated on allograft mice with Lewis carcinoma cell inoculation. The relative cell proliferation was measured with Cell Counting Kit-8 (CCK-8). The invasive capacity was evaluated by transwell assay. The interaction between USP10 and Phosphatase And Tensin Homolog (PTEN) was examined by co-immunoprecipitation. Ubiquitination/deubiquitination was analyzed by immunoprecipitation followed by immunoblotting. USP10 was down-regulated in lung cancer. Knockdown of USP10 promotes tumor growth and invasion both in vitro and in vivo. We further demonstrated that USP10 directly interacted with and stabilized PTEN via deubiquitination. The pro-cancerous effect of USP10 deficiency was abolished by re-introduction of PTEN. We suggested a tumor suppressor function of USP10 in lung cancer via deubiquitinating and stabilizing PTEN.
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      headline:USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN
      description:To determine the potential tumor suppressor functions of ubiquitin-specific protease 10 (USP10) in lung cancer and elucidate underlying molecular mechanism. The relative expression of USP10 was determined by real-time PCR and immunoblotting. The inhibitory effect of USP10 on tumor growth was demonstrated on allograft mice with Lewis carcinoma cell inoculation. The relative cell proliferation was measured with Cell Counting Kit-8 (CCK-8). The invasive capacity was evaluated by transwell assay. The interaction between USP10 and Phosphatase And Tensin Homolog (PTEN) was examined by co-immunoprecipitation. Ubiquitination/deubiquitination was analyzed by immunoprecipitation followed by immunoblotting. USP10 was down-regulated in lung cancer. Knockdown of USP10 promotes tumor growth and invasion both in vitro and in vivo. We further demonstrated that USP10 directly interacted with and stabilized PTEN via deubiquitination. The pro-cancerous effect of USP10 deficiency was abolished by re-introduction of PTEN. We suggested a tumor suppressor function of USP10 in lung cancer via deubiquitinating and stabilizing PTEN.
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