We are analyzing https://link.springer.com/article/10.1007/s11010-011-0887-1.

Title:
Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease | Molecular and Cellular Biochemistry
Description:
It has been suggested that oxidative stress may participate in the progression of diabetes and its complications. Long-term complications of type 2 diabetes mellitus (T2DM) include retinopathy, atherosclerosis, shortened life span of erythrocytes, nephropathy, and chronic kidney disease (CKD). Oxidative damage has been associated with erythrocyte apoptosis induction in other pathological conditions. Our aim was to study the presence of eryptosis and its possible relationship with oxidative damage in patients with T2DM without CKD (T2DM/CKD(−)) and in patients with T2DM and CKD (T2DM/CKD(+)).Oxidative damage of lipids erythrocytes were increased in diabetic patients. The highest lipoperoxidation was found in T2DM/CKD(+). Likewise, the lower plasma total antioxidant capacity, GSH/GSSG ratio, and GSH in erythrocytes were found in T2DM/CKD(+) patients. A negative correlation was found between plasma total antioxidant capacity and oxidative damage. Phosphatidylserine (PS) externalization was measured in erythrocytes to evaluate eryptosis. Annexin binding in erythrocytes of T2DM/CKD(+) patients was higher than in healthy subjects and T2DM/CKD(−) patients. A positive correlation between lipoperoxidation and PS externalization in erythrocytes was found. This work showed that the erythrocytes of diabetic patients have increased oxidative damage, a reduction of antioxidant systems and more erythrocyte PS externalization. The duration of diabetes and the presence of CKD increase both oxidative damage and eryptosis. It is possible that a longer time of evolution induces an increase in erythrocyte oxidative damage and the consumption of blood antioxidant systems, adding to the osmotic stress in CKD and so contributes to an increase in PS externalization in diabetic patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Insurance

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

article, google, scholar, pubmed, diabetes, cas, oxidative, diabetic, patients, damage, kidney, stress, erythrocytes, type, erythrocyte, biochem, antioxidant, lang, disease, phosphatidylserine, cell, content, eryptosis, mellitus, chronic, ckd, death, privacy, cookies, complications, nephropathy, tdmckd, externalization, access, publish, research, search, calderónsalinas, quintanarescorza, found, subjects, reactive, oxygen, species, lipid, peroxidation, med, physiol, insulin, durango,

Topics {✒️}

org/professionals/kdoqi/guideline_diabetes/guide2 high-sensitivity c-reactive protein month download article/chapter org/content/30/suppl_1/s42 intriago-ortega mp privacy choices/manage cookies total antioxidant capacity full article pdf quintanar-escorza facultad de medicina centro de investigación gonzález rico ma solís salguero ma chronic renal failure article calderón-salinas cellular biochemistry aims ros-related targets chronic kidney disease abnormal phosphatidylserine exposure membrane phosphatidylserine content insulin resistance due advanced kidney disease reactive oxygen species erythrocyte sedimentation rate diabetic kidney disease blood antioxidant systems antioxidant enzyme activities antioxidant enzyme activity del razo lm article molecular european economic area scope submit manuscript shortened life span anti-oxidant defence serum lipid peroxidation lipid peroxidation status skeletal muscle dysfunction van der vlag literature-based discovery race-specific differences programmed erythrocyte death erythrocyte oxidative damage antioxidant enzyme levels early diabetic nephropathy calderon-salinas jv suicidal erythrocyte death long-term complications insulin receptor substrate-1 targeting oxidative stress related subjects

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease
         description:It has been suggested that oxidative stress may participate in the progression of diabetes and its complications. Long-term complications of type 2 diabetes mellitus (T2DM) include retinopathy, atherosclerosis, shortened life span of erythrocytes, nephropathy, and chronic kidney disease (CKD). Oxidative damage has been associated with erythrocyte apoptosis induction in other pathological conditions. Our aim was to study the presence of eryptosis and its possible relationship with oxidative damage in patients with T2DM without CKD (T2DM/CKD(−)) and in patients with T2DM and CKD (T2DM/CKD(+)).Oxidative damage of lipids erythrocytes were increased in diabetic patients. The highest lipoperoxidation was found in T2DM/CKD(+). Likewise, the lower plasma total antioxidant capacity, GSH/GSSG ratio, and GSH in erythrocytes were found in T2DM/CKD(+) patients. A negative correlation was found between plasma total antioxidant capacity and oxidative damage. Phosphatidylserine (PS) externalization was measured in erythrocytes to evaluate eryptosis. Annexin binding in erythrocytes of T2DM/CKD(+) patients was higher than in healthy subjects and T2DM/CKD(−) patients. A positive correlation between lipoperoxidation and PS externalization in erythrocytes was found. This work showed that the erythrocytes of diabetic patients have increased oxidative damage, a reduction of antioxidant systems and more erythrocyte PS externalization. The duration of diabetes and the presence of CKD increase both oxidative damage and eryptosis. It is possible that a longer time of evolution induces an increase in erythrocyte oxidative damage and the consumption of blood antioxidant systems, adding to the osmotic stress in CKD and so contributes to an increase in PS externalization in diabetic patients.
         datePublished:2011-05-28T00:00:00Z
         dateModified:2011-05-28T00:00:00Z
         pageStart:171
         pageEnd:179
         sameAs:https://doi.org/10.1007/s11010-011-0887-1
         keywords:
            Phosphatidylserine (PS)
            Kidney diseases
            Oxidative stress
            Eryptosis
            Diabetes
            Biochemistry
            general
            Cardiology
            Cancer Research
            Medical Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig6_HTML.gif
         isPartOf:
            name:Molecular and Cellular Biochemistry
            issn:
               1573-4919
               0300-8177
            volumeNumber:357
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:J. V. Calderón-Salinas
               affiliation:
                     name:Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN)
                     address:
                        name:Departamento de Bioquímica, Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN), México City, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:E. G. Muñoz-Reyes
               affiliation:
                     name:UJED
                     address:
                        name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J. F. Guerrero-Romero
               affiliation:
                     name:Mexican Social Security Institute
                     address:
                        name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. Rodríguez-Morán
               affiliation:
                     name:Mexican Social Security Institute
                     address:
                        name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:R. L. Bracho-Riquelme
               affiliation:
                     name:Universidad Juárez del Estado de Durango (UJED)
                     address:
                        name:División de Estudios de Posgrado, Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango (UJED), Durango, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. A. Carrera-Gracia
               affiliation:
                     name:UJED
                     address:
                        name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. A. Quintanar-Escorza
               affiliation:
                     name:UJED
                     address:
                        name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease
      description:It has been suggested that oxidative stress may participate in the progression of diabetes and its complications. Long-term complications of type 2 diabetes mellitus (T2DM) include retinopathy, atherosclerosis, shortened life span of erythrocytes, nephropathy, and chronic kidney disease (CKD). Oxidative damage has been associated with erythrocyte apoptosis induction in other pathological conditions. Our aim was to study the presence of eryptosis and its possible relationship with oxidative damage in patients with T2DM without CKD (T2DM/CKD(−)) and in patients with T2DM and CKD (T2DM/CKD(+)).Oxidative damage of lipids erythrocytes were increased in diabetic patients. The highest lipoperoxidation was found in T2DM/CKD(+). Likewise, the lower plasma total antioxidant capacity, GSH/GSSG ratio, and GSH in erythrocytes were found in T2DM/CKD(+) patients. A negative correlation was found between plasma total antioxidant capacity and oxidative damage. Phosphatidylserine (PS) externalization was measured in erythrocytes to evaluate eryptosis. Annexin binding in erythrocytes of T2DM/CKD(+) patients was higher than in healthy subjects and T2DM/CKD(−) patients. A positive correlation between lipoperoxidation and PS externalization in erythrocytes was found. This work showed that the erythrocytes of diabetic patients have increased oxidative damage, a reduction of antioxidant systems and more erythrocyte PS externalization. The duration of diabetes and the presence of CKD increase both oxidative damage and eryptosis. It is possible that a longer time of evolution induces an increase in erythrocyte oxidative damage and the consumption of blood antioxidant systems, adding to the osmotic stress in CKD and so contributes to an increase in PS externalization in diabetic patients.
      datePublished:2011-05-28T00:00:00Z
      dateModified:2011-05-28T00:00:00Z
      pageStart:171
      pageEnd:179
      sameAs:https://doi.org/10.1007/s11010-011-0887-1
      keywords:
         Phosphatidylserine (PS)
         Kidney diseases
         Oxidative stress
         Eryptosis
         Diabetes
         Biochemistry
         general
         Cardiology
         Cancer Research
         Medical Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11010-011-0887-1/MediaObjects/11010_2011_887_Fig6_HTML.gif
      isPartOf:
         name:Molecular and Cellular Biochemistry
         issn:
            1573-4919
            0300-8177
         volumeNumber:357
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:J. V. Calderón-Salinas
            affiliation:
                  name:Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN)
                  address:
                     name:Departamento de Bioquímica, Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN), México City, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:E. G. Muñoz-Reyes
            affiliation:
                  name:UJED
                  address:
                     name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. F. Guerrero-Romero
            affiliation:
                  name:Mexican Social Security Institute
                  address:
                     name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Rodríguez-Morán
            affiliation:
                  name:Mexican Social Security Institute
                  address:
                     name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:R. L. Bracho-Riquelme
            affiliation:
                  name:Universidad Juárez del Estado de Durango (UJED)
                  address:
                     name:División de Estudios de Posgrado, Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango (UJED), Durango, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. A. Carrera-Gracia
            affiliation:
                  name:UJED
                  address:
                     name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. A. Quintanar-Escorza
            affiliation:
                  name:UJED
                  address:
                     name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Molecular and Cellular Biochemistry
      issn:
         1573-4919
         0300-8177
      volumeNumber:357
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN)
      address:
         name:Departamento de Bioquímica, Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN), México City, Mexico
         type:PostalAddress
      name:UJED
      address:
         name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
         type:PostalAddress
      name:Mexican Social Security Institute
      address:
         name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
         type:PostalAddress
      name:Mexican Social Security Institute
      address:
         name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
         type:PostalAddress
      name:Universidad Juárez del Estado de Durango (UJED)
      address:
         name:División de Estudios de Posgrado, Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango (UJED), Durango, Mexico
         type:PostalAddress
      name:UJED
      address:
         name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
         type:PostalAddress
      name:UJED
      address:
         name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:J. V. Calderón-Salinas
      affiliation:
            name:Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN)
            address:
               name:Departamento de Bioquímica, Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN), México City, Mexico
               type:PostalAddress
            type:Organization
      name:E. G. Muñoz-Reyes
      affiliation:
            name:UJED
            address:
               name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
               type:PostalAddress
            type:Organization
      name:J. F. Guerrero-Romero
      affiliation:
            name:Mexican Social Security Institute
            address:
               name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
               type:PostalAddress
            type:Organization
      name:M. Rodríguez-Morán
      affiliation:
            name:Mexican Social Security Institute
            address:
               name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
               type:PostalAddress
            type:Organization
      name:R. L. Bracho-Riquelme
      affiliation:
            name:Universidad Juárez del Estado de Durango (UJED)
            address:
               name:División de Estudios de Posgrado, Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango (UJED), Durango, Mexico
               type:PostalAddress
            type:Organization
      name:M. A. Carrera-Gracia
      affiliation:
            name:UJED
            address:
               name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
               type:PostalAddress
            type:Organization
      name:M. A. Quintanar-Escorza
      affiliation:
            name:UJED
            address:
               name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departamento de Bioquímica, Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN), México City, Mexico
      name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
      name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
      name:Medical Research Unit, Mexican Social Security Institute, Durango, Mexico
      name:División de Estudios de Posgrado, Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango (UJED), Durango, Mexico
      name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
      name:Departamento de Bioquímica, Facultad de Medicina y Nutrición, UJED, Durango, Mexico
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(128)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.3s.

LINK . SPRINGER . COM {}