We are analyzing https://link.springer.com/article/10.1007/s11010-011-0782-9.

Title:
Association between circulating interleukin-1 beta (IL-1β) levels and IL-1β C–511T polymorphism with cervical cancer risk in Egyptian women | Molecular and Cellular Biochemistry
Description:
Cancer cervix is one of the leading causes of cancer-related mortality among women worldwide. It is believed that the host genetic factors such as inflammation-induced cytokines may play a role in cervical carcinogenesis. The interleukin-1β (IL-1β) gene contains several single nucleotide polymorphisms. One of them, C–511T, which in the promoter region has been associated with increased IL-1β production and with increased risk of developing cancers. We assessed the association between the IL-1β C–511T polymorphism and cervical cancer risk in a case–control study among 100 histopathologically confirmed Egyptian women with cervical cancer and 50 age-matched, cervical cytology negative, healthy controls by polymerase chain reaction-restriction fragment length polymorphism. Plasma levels of IL-1β were assayed by enzyme-linked immunosorbent assay. There was significant increase in the mean plasma IL-1β level in cervical cancer cases (43.40 ± 25.95 pg/ml) when compared with controls (30.51 ± 18.28 pg/ml, P = 0.002). The plasma levels above the 75th percentile of controls (IL-1β ≥ 45.74 pg/ml) were significantly associated with a 2.49-fold increased risk of cervical cancer. The significant increase in IL-1β concentration in cervical cancer cases was observed only among cervical cancer cases carrying C–511T variant genotypes. T/T genotype of IL-1β polymorphism was significantly higher in cervical cancer cases compared with controls (57 vs. 38%; OR = 2.16; P = 0.028) and the T allele carriage was significantly associated with cervical cancer risk (OR = 2.00, 95% CI = 1.19–3.38, and P = 0.008). In conclusion, plasma IL-1β level and IL-1β C–511T polymorphism may be considered as candidate biomarkers for cervical cancer in Egyptian women.
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cancer, article, google, scholar, pubmed, cervical, cas, interleukin, ilβ, polymorphism, risk, beta, gene, polymorphisms, increased, association, human, interleukinbeta, women, levels, int, kim, lee, privacy, cookies, content, access, papillomavirus, van, wang, cytokine, publish, search, egyptian, etewa, genetic, promoter, casecontrol, controls, plasma, cases, significantly, nature, chen, gastric, zagazig, analysis, data, information, log,

Topics {✒️}

month download article/chapter enzyme-linked immunosorbent assay macrophage colony-stimulating factor tumour necrosis factor-alpha nitric oxide-dependent mechanism high-grade cervical neoplasia kordi tamandani dm interleukin-1beta gene polymorphism interleukin 1b rs16944 polymorphisms plasma il-1β level full article pdf increased il-1β production tnf-alpha promoter polymorphisms privacy choices/manage cookies interleukin-1 receptor antagonist human papillomavirus dna circulating il-1β levels article al-tahhan fraumeni jf jr ter schegget js e6–p53 interaction oncogenic human papillomavirus human papillomavirus cofactor interleukin-1 beta gene gene polymorphism coding epithelial ovarian cancer interleukin-1beta gene cervical cancer cases van der vange type-specific persistence inhibit dna repair circulating interleukin-1 beta cellular biochemistry aims high secretor phenotype interleukin-17a polymorphism case–control analysis cervical cancer screening invasive cervical cancer interleukin-1b genes interleukin-1 beta protein single base polymorphism interleukin-1beta–511 polymorphism cervical cytology negative cancer-related mortality 511t polymorphism access european economic area developing cancers case–control study case-control study ten kate fw

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         headline:Association between circulating interleukin-1 beta (IL-1β) levels and IL-1β C–511T polymorphism with cervical cancer risk in Egyptian women
         description:Cancer cervix is one of the leading causes of cancer-related mortality among women worldwide. It is believed that the host genetic factors such as inflammation-induced cytokines may play a role in cervical carcinogenesis. The interleukin-1β (IL-1β) gene contains several single nucleotide polymorphisms. One of them, C–511T, which in the promoter region has been associated with increased IL-1β production and with increased risk of developing cancers. We assessed the association between the IL-1β C–511T polymorphism and cervical cancer risk in a case–control study among 100 histopathologically confirmed Egyptian women with cervical cancer and 50 age-matched, cervical cytology negative, healthy controls by polymerase chain reaction-restriction fragment length polymorphism. Plasma levels of IL-1β were assayed by enzyme-linked immunosorbent assay. There was significant increase in the mean plasma IL-1β level in cervical cancer cases (43.40 ± 25.95 pg/ml) when compared with controls (30.51 ± 18.28 pg/ml, P = 0.002). The plasma levels above the 75th percentile of controls (IL-1β ≥ 45.74 pg/ml) were significantly associated with a 2.49-fold increased risk of cervical cancer. The significant increase in IL-1β concentration in cervical cancer cases was observed only among cervical cancer cases carrying C–511T variant genotypes. T/T genotype of IL-1β polymorphism was significantly higher in cervical cancer cases compared with controls (57 vs. 38%; OR = 2.16; P = 0.028) and the T allele carriage was significantly associated with cervical cancer risk (OR = 2.00, 95% CI = 1.19–3.38, and P = 0.008). In conclusion, plasma IL-1β level and IL-1β C–511T polymorphism may be considered as candidate biomarkers for cervical cancer in Egyptian women.
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            Interleukin 1β gene
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            Biochemistry
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            Cardiology
            Cancer Research
            Medical Biochemistry
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      headline:Association between circulating interleukin-1 beta (IL-1β) levels and IL-1β C–511T polymorphism with cervical cancer risk in Egyptian women
      description:Cancer cervix is one of the leading causes of cancer-related mortality among women worldwide. It is believed that the host genetic factors such as inflammation-induced cytokines may play a role in cervical carcinogenesis. The interleukin-1β (IL-1β) gene contains several single nucleotide polymorphisms. One of them, C–511T, which in the promoter region has been associated with increased IL-1β production and with increased risk of developing cancers. We assessed the association between the IL-1β C–511T polymorphism and cervical cancer risk in a case–control study among 100 histopathologically confirmed Egyptian women with cervical cancer and 50 age-matched, cervical cytology negative, healthy controls by polymerase chain reaction-restriction fragment length polymorphism. Plasma levels of IL-1β were assayed by enzyme-linked immunosorbent assay. There was significant increase in the mean plasma IL-1β level in cervical cancer cases (43.40 ± 25.95 pg/ml) when compared with controls (30.51 ± 18.28 pg/ml, P = 0.002). The plasma levels above the 75th percentile of controls (IL-1β ≥ 45.74 pg/ml) were significantly associated with a 2.49-fold increased risk of cervical cancer. The significant increase in IL-1β concentration in cervical cancer cases was observed only among cervical cancer cases carrying C–511T variant genotypes. T/T genotype of IL-1β polymorphism was significantly higher in cervical cancer cases compared with controls (57 vs. 38%; OR = 2.16; P = 0.028) and the T allele carriage was significantly associated with cervical cancer risk (OR = 2.00, 95% CI = 1.19–3.38, and P = 0.008). In conclusion, plasma IL-1β level and IL-1β C–511T polymorphism may be considered as candidate biomarkers for cervical cancer in Egyptian women.
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         Cervical cancer
         Interleukin 1β gene
         C–511T polymorphism
         Biochemistry
         general
         Cardiology
         Cancer Research
         Medical Biochemistry
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