We are analyzing https://link.springer.com/article/10.1007/s11010-006-9389-y.

Title:
Importance of the trans-sulfuration pathway in cancer prevention and promotion | Molecular and Cellular Biochemistry
Description:
The trans-sulfuration pathway is a biochemical mechanism that links methionine metabolism to the biosynthesis of cellular redox-controlling molecules, like cysteine, glutathione, and taurine. While there is some knowledge about the metabolic intermediates and enzymes that participate in trans-sulfuration, little is known about the physiological importance of this mechanism. Deficiencies within the trans-sulfuration pathway induces (i) the generation of reactive species of oxygen (ROS) and halogens (RHS), (ii) homocyst(e)ine accumulation, and (iii) the synthesis of proinflammatory molecules by macrophages, and contribute to humans pathologies like atherosclerosis and tumor development. In this review we outline the role of this biochemical pathway in tumor development and analyze current findings on the role of trans-sulfuration in mammalian physiology. The potential relationship between chronic inflammation, and tumor and atherosclerotic development are discussed.
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Keywords {🔍}

google, scholar, cas, pubmed, cancer, human, biol, glutathione, res, dna, cystathionine, article, cells, chem, pathway, methionine, taurine, tumor, role, rev, biochem, cell, content, transsulfuration, metabolism, oxidative, homocysteine, sadenosylhomocysteine, hydrolase, biochemistry, inflammation, regulation, sci, pharmacol, clin, repair, damage, cysteine, metabolic, atherosclerosis, access, lung, hum, rat, banerjee, redox, natl, wang, βsynthase, privacy,

Topics {✒️}

month download article/chapter mirian salvador & diego bonatto trans-sulfuration pathway induces reactive species human cystathionine β-synthase bleomycin-induced lung fibrosis amiodarone-induced lung fibrosis murine cystathionine γ-lyase acute no2-induced alterations cystathionine beta-synthase mutations guinea-pig pulmonary arteries including heat-labile sites long-term parenteral nutrition methyl-cpg-binding protein 2 homocysteine-linked redox homeostasis brown-borg hm selenomethionyl s-adenosylhomocysteine hydrolase purified s-adenosylhomocysteine hydrolase redox-active sulfur compounds cystathionine β-synthase s-adenosyl-l-methionine s-adenosylhomocysteine hydrolase deficiency cellular redox-controlling molecules anti-cancer drug resistance xrcc1/dna ligase iii cystathionine γ-lyase c-h-ras oncogene methyl-cpg-binding domain trans-sulfuration pathway long-term depletion cystathionine gamma-lyase privacy choices/manage cookies ames dwarf mice cellular redox state modulates redox capacity s-adenosylhomocysteine hydrolase metabolic screening program full article pdf de meyer gry fundação de amparo methionine metabolic pathway h2s-dependent modulation chronic inflammation common molecular pathway schuller-levis potential tumor marker hepatic glutathione synthesis universidade de caxias comprehensive pathway analysis fresh patient tumors

Questions {❓}

Heidland A, Klassen A, Rutkowski P, Bahner U (2006) The contribution of Rudolf Virchow to the concept of inflammation: what is still of importance?
Li JJ, Gao R-L (2005) Should atherosclerosis be considered a cancer of the vascular wall?

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