We are analyzing https://link.springer.com/article/10.1007/s10875-005-7828-2.

Title:
Protective Molecules–C-Reactive Protein (CRP), Serum Amyloid P (SAP), Pentraxin3 (PTX3), Mannose-Binding Lectin (MBL), and Apolipoprotein A1 (Apo A1), and Their Autoantibodies: Prevalence and Clinical Significance in Autoimmunity | Journal of Clinical Immunology
Description:
Apoptotic defects and impaired clearance of cellular debris are considered key events in the development of autoimmunity, as they can contribute to autoantigen overload, and may initiate an autoimmune response. The pentraxins are a group of highly conserved proteins including the short pentraxins, C-reactive protein (CRP) and serum amyloid-P (SAP), and the long pentraxin-3 (PTX3), which are all involved in innate immunity and in acute-phase responses. Mannan-binding lectin (MBL) is an activator of the complement system, and Apolipoprotein A-1 (Apo A-1) is pivotal in the cholesterol homeostasis and has anti-inflammatory properties. In addition to their role in innate immunity and inflammation, each of these five proteins participates in the removal of damaged and apoptotic cells. In this review, we discuss the clinical significance of different levels of these proteins, their role in the induction or protection from autoimmunity, and the presence of specific autoantibodies against them in the different autoimmune diseases.
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Keywords {🔍}

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Topics {✒️}

protective molecules–c-reactive protein complement-dependent acute-phase expression month download article/chapter mannose-binding lectin deficiency—revisited anti-inflammatory properties rabbit c-reactive protein mannose-binding lectin gene acute-phase proteins mannose-binding lectin genotypes considered key events anti-serum amyloid mannose-binding lectin insufficiency laura schwatz-kipp chair monomeric c-reactive protein anti-apolipoprotein a c-reactive protein binds c-reactive protein expression mannose-binding lectin polymorphisms mannose-binding-lectin deficiency antigen-presenting dendritic cells acute phase response van gijlswijk-janssen dj end-stage renal disease long pentraxin ptx3—similarities mannan-binding lectin pathway acute-phase responses full article pdf low mbl production mannose-binding protein mannose-binding lectin mannose binding lectin clinical immunology aims c-reactive protein regulates tissue factor privacy choices/manage cookies acute coronary syndrome f1 mice expressing mannan-binding lectin mannan binding lectin o'hara bp cell surface calreticulin acute myocardial infarction long pentraxin ptx3 article kravitz human endothelial cells systemic lupus erythematosus check access instant access terminal complement components prototypical long pentraxin

Questions {❓}

Arici M, Walls J: End-stage renal disease, atherosclerosis, and cardiovascular mortality: Is C-reactive protein the missing link?
Bresnihan B, Gogarty M, Fitzgerald O, Dayer JM, Burger D: Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: A control mechanism of cytokine production?
Burger D, Dayer JM: High-density lipoprotein-associated apolipoprotein A-I: The missing link between infection and chronic inflammation?

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         description:Apoptotic defects and impaired clearance of cellular debris are considered key events in the development of autoimmunity, as they can contribute to autoantigen overload, and may initiate an autoimmune response. The pentraxins are a group of highly conserved proteins including the short pentraxins, C-reactive protein (CRP) and serum amyloid-P (SAP), and the long pentraxin-3 (PTX3), which are all involved in innate immunity and in acute-phase responses. Mannan-binding lectin (MBL) is an activator of the complement system, and Apolipoprotein A-1 (Apo A-1) is pivotal in the cholesterol homeostasis and has anti-inflammatory properties. In addition to their role in innate immunity and inflammation, each of these five proteins participates in the removal of damaged and apoptotic cells. In this review, we discuss the clinical significance of different levels of these proteins, their role in the induction or protection from autoimmunity, and the presence of specific autoantibodies against them in the different autoimmune diseases.
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      description:Apoptotic defects and impaired clearance of cellular debris are considered key events in the development of autoimmunity, as they can contribute to autoantigen overload, and may initiate an autoimmune response. The pentraxins are a group of highly conserved proteins including the short pentraxins, C-reactive protein (CRP) and serum amyloid-P (SAP), and the long pentraxin-3 (PTX3), which are all involved in innate immunity and in acute-phase responses. Mannan-binding lectin (MBL) is an activator of the complement system, and Apolipoprotein A-1 (Apo A-1) is pivotal in the cholesterol homeostasis and has anti-inflammatory properties. In addition to their role in innate immunity and inflammation, each of these five proteins participates in the removal of damaged and apoptotic cells. In this review, we discuss the clinical significance of different levels of these proteins, their role in the induction or protection from autoimmunity, and the presence of specific autoantibodies against them in the different autoimmune diseases.
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      dateModified:
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         anti-CRP
         anti-SAP
         anti-PTX3
         anti-MBL
         anti ApoA1
         autoimmunity
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         Infectious Diseases
         Internal Medicine
         Medical Microbiology
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