We are analyzing https://link.springer.com/article/10.1007/s10863-006-9008-3.

Title:
Effects of Arachidonic Acid on the Lysosomal Ion Permeability and Osmotic Stability | Journal of Bioenergetics and Biomembranes
Description:
In this study, we investigated the effects of arachidonic acid, a PLA2-produced lipid metabolite, on the lysosomal permeability, osmotic sensitivity and stability. Through the measurements of lysosomal β-hexosaminidase free activity, membrane potential, intralysosomal pH, and lysosomal latency loss in hypotonic sucrose medium, we established that arachidonic acid could increase the lysosomal permeability to both potassium ions and protons, and enhance the lysosomal osmotic sensitivity. As a result, the fatty-acid-promoted entry of potassium ions into the lysosomes via K+/H+ exchange, which could produce osmotic imbalance across their membranes and osmotically destabilize the lysosomes. In addition, the enhancement of lysosomal osmotic sensitivity caused the lysosomes to become more liable to destabilization in osmotic shock. The results suggest that arachidonic acid may play a role in the lysosomal destabilization.
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Topics {✒️}

month download article/chapter fatty-acid-promoted entry guo-jiang zhang pla2-produced lipid metabolite lysosomal ion permeability lysosomal osmotic sensitivity related subjects full article pdf privacy choices/manage cookies lysosomal latency loss produce osmotic imbalance article zhang osmotic sensitivity european economic area hypotonic sucrose medium substrate overload induces transport abbreviations cccp lloyd jb check access instant access lysosomal permeability conditions privacy policy membrane potential article journal zhang g accepting optional cookies brunk ut journal finder publish article log main content log potassium ions author correspondence article cite arachidonic acid zhong y osmotic stability lysosome osmotic shock lysosomal destabilization privacy policy personal data cell biol 33 books a yi wang y optional cookies manage preferences biophysics journal publish data protection

Schema {🗺️}

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         headline:Effects of Arachidonic Acid on the Lysosomal Ion Permeability and Osmotic Stability
         description:In this study, we investigated the effects of arachidonic acid, a PLA2-produced lipid metabolite, on the lysosomal permeability, osmotic sensitivity and stability. Through the measurements of lysosomal β-hexosaminidase free activity, membrane potential, intralysosomal pH, and lysosomal latency loss in hypotonic sucrose medium, we established that arachidonic acid could increase the lysosomal permeability to both potassium ions and protons, and enhance the lysosomal osmotic sensitivity. As a result, the fatty-acid-promoted entry of potassium ions into the lysosomes via K+/H+ exchange, which could produce osmotic imbalance across their membranes and osmotically destabilize the lysosomes. In addition, the enhancement of lysosomal osmotic sensitivity caused the lysosomes to become more liable to destabilization in osmotic shock. The results suggest that arachidonic acid may play a role in the lysosomal destabilization.
         datePublished:2006-05-27T00:00:00Z
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            Osmotic sensitivity
            Bioorganic Chemistry
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            Organic Chemistry
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      headline:Effects of Arachidonic Acid on the Lysosomal Ion Permeability and Osmotic Stability
      description:In this study, we investigated the effects of arachidonic acid, a PLA2-produced lipid metabolite, on the lysosomal permeability, osmotic sensitivity and stability. Through the measurements of lysosomal β-hexosaminidase free activity, membrane potential, intralysosomal pH, and lysosomal latency loss in hypotonic sucrose medium, we established that arachidonic acid could increase the lysosomal permeability to both potassium ions and protons, and enhance the lysosomal osmotic sensitivity. As a result, the fatty-acid-promoted entry of potassium ions into the lysosomes via K+/H+ exchange, which could produce osmotic imbalance across their membranes and osmotically destabilize the lysosomes. In addition, the enhancement of lysosomal osmotic sensitivity caused the lysosomes to become more liable to destabilization in osmotic shock. The results suggest that arachidonic acid may play a role in the lysosomal destabilization.
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         Arachidonic acid
         Permeability
         Potassium ion
         Proton
         Osmotic sensitivity
         Bioorganic Chemistry
         Biochemistry
         general
         Animal Anatomy / Morphology / Histology
         Animal Biochemistry
         Organic Chemistry
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