We are analyzing https://link.springer.com/article/10.1007/s10863-006-9003-8.

Title:
The ROS Production Induced by a Reverse-Electron Flux at Respiratory-Chain Complex 1 is Hampered by Metformin | Journal of Bioenergetics and Biomembranes
Description:
Mitochondrial reactive oxygen species (ROS) production was investigated in mitochondria extracted from liver of rats treated with or without metformin, a mild inhibitor of respiratory chain complex 1 used in type 2 diabetes. A high rate of ROS production, fully suppressed by rotenone, was evidenced in non-phosphorylating mitochondria in the presence of succinate as a single complex 2 substrate. This ROS production was substantially lowered by metformin pretreatment and by any decrease in membrane potential (Δ < eqid1 > m), redox potential (NADH/NAD), or phosphate potential, as induced by malonate, 2,4-dinitrophenol, or ATP synthesis, respectively. ROS production in the presence of glutamate–malate plus succinate was lower than in the presence of succinate alone, but higher than in the presence of glutamate–malate. Moreover, while rotenone both increased and decreased ROS production at complex 1 depending on forward (glutamate–malate) or reverse (succinate) electron flux, no ROS overproduction was evidenced in the forward direction with metformin. Therefore, we propose that reverse electron flux through complex 1 is an alternative pathway, which leads to a specific metformin-sensitive ROS production.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Video & Online Content
Music

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,182 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

article, google, scholar, cas, pubmed, biol, ros, chem, production, biochem, complex, metformin, guigas, fontaine, mitochondrial, potential, privacy, cookies, content, journal, detaille, leverve, oxygen, physiol, author, publish, search, flux, batandier, reactive, species, presence, succinate, membrane, electron, access, nature, data, information, log, research, induced, bruno, elmir, eric, mitochondria, diabetes, rotenone, redox, glutamatemalate,

Topics {✒️}

month download article/chapter eric fontaine eric fontaine bruno guigas author correspondence membrane potential liver malonate reactive oxygen species redox potential electrical potential difference mitochondria extracted phosphorylating mitochondria full article pdf respiratory-chain complex 1 decreased ros production privacy choices/manage cookies check access instant access type 2 diabetes ros production induced related subjects membrane δphm membrane dnp appliquée inserm e-0221 el-mir rotenone universit joseph fourier european economic area conditions privacy policy phosphate potential article batandier ros production article journal accepting optional cookies reverse-electron flux reverse electron flux journal finder publish reverse electron transfer metformin pretreatment main content log biomembranes article article log ros overproduction article cite fontaine de oliveira guigas physiol rev 82 metformin

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The ROS Production Induced by a Reverse-Electron Flux at Respiratory-Chain Complex 1 is Hampered by Metformin
         description:Mitochondrial reactive oxygen species (ROS) production was investigated in mitochondria extracted from liver of rats treated with or without metformin, a mild inhibitor of respiratory chain complex 1 used in type 2 diabetes. A high rate of ROS production, fully suppressed by rotenone, was evidenced in non-phosphorylating mitochondria in the presence of succinate as a single complex 2 substrate. This ROS production was substantially lowered by metformin pretreatment and by any decrease in membrane potential (Δ < eqid1 > m), redox potential (NADH/NAD), or phosphate potential, as induced by malonate, 2,4-dinitrophenol, or ATP synthesis, respectively. ROS production in the presence of glutamate–malate plus succinate was lower than in the presence of succinate alone, but higher than in the presence of glutamate–malate. Moreover, while rotenone both increased and decreased ROS production at complex 1 depending on forward (glutamate–malate) or reverse (succinate) electron flux, no ROS overproduction was evidenced in the forward direction with metformin. Therefore, we propose that reverse electron flux through complex 1 is an alternative pathway, which leads to a specific metformin-sensitive ROS production.
         datePublished:2006-05-27T00:00:00Z
         dateModified:2006-05-27T00:00:00Z
         pageStart:33
         pageEnd:42
         sameAs:https://doi.org/10.1007/s10863-006-9003-8
         keywords:
            Metformin
            ROS
            Oxidative phosphorylation
            Rat liver mitochondria
            Rotenone
            Malonate
            Antimycin
            Membrane potential
            Bioorganic Chemistry
            Biochemistry
            general
            Animal Anatomy / Morphology / Histology
            Animal Biochemistry
            Organic Chemistry
         image:
         isPartOf:
            name:Journal of Bioenergetics and Biomembranes
            issn:
               1573-6881
               0145-479X
            volumeNumber:38
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Cécile Batandier
               affiliation:
                     name:Universit Joseph Fourier
                     address:
                        name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bruno Guigas
               affiliation:
                     name:Universit Joseph Fourier
                     address:
                        name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dominique Detaille
               affiliation:
                     name:Universit Joseph Fourier
                     address:
                        name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. El-Mir
               affiliation:
                     name:University of Salamanca
                     address:
                        name:Faculty of Pharmacy, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eric Fontaine
               affiliation:
                     name:Universit Joseph Fourier
                     address:
                        name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. Rigoulet
               affiliation:
                     name:Universit de Bordeaux II
                     address:
                        name:Institut de Biochimie et de Génétique Cellulaire de CNRS, Universit de Bordeaux II, Bordeaux Cedex, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:X. M. Leverve
               affiliation:
                     name:Universit Joseph Fourier
                     address:
                        name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                        type:PostalAddress
                     type:Organization
                     name:Universit Joseph Fourier
                     address:
                        name:Bioénergétique Fondamentale et Appliquée INSERM E-0221, Universit Joseph Fourier, Grenoble Cedex, France
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The ROS Production Induced by a Reverse-Electron Flux at Respiratory-Chain Complex 1 is Hampered by Metformin
      description:Mitochondrial reactive oxygen species (ROS) production was investigated in mitochondria extracted from liver of rats treated with or without metformin, a mild inhibitor of respiratory chain complex 1 used in type 2 diabetes. A high rate of ROS production, fully suppressed by rotenone, was evidenced in non-phosphorylating mitochondria in the presence of succinate as a single complex 2 substrate. This ROS production was substantially lowered by metformin pretreatment and by any decrease in membrane potential (Δ < eqid1 > m), redox potential (NADH/NAD), or phosphate potential, as induced by malonate, 2,4-dinitrophenol, or ATP synthesis, respectively. ROS production in the presence of glutamate–malate plus succinate was lower than in the presence of succinate alone, but higher than in the presence of glutamate–malate. Moreover, while rotenone both increased and decreased ROS production at complex 1 depending on forward (glutamate–malate) or reverse (succinate) electron flux, no ROS overproduction was evidenced in the forward direction with metformin. Therefore, we propose that reverse electron flux through complex 1 is an alternative pathway, which leads to a specific metformin-sensitive ROS production.
      datePublished:2006-05-27T00:00:00Z
      dateModified:2006-05-27T00:00:00Z
      pageStart:33
      pageEnd:42
      sameAs:https://doi.org/10.1007/s10863-006-9003-8
      keywords:
         Metformin
         ROS
         Oxidative phosphorylation
         Rat liver mitochondria
         Rotenone
         Malonate
         Antimycin
         Membrane potential
         Bioorganic Chemistry
         Biochemistry
         general
         Animal Anatomy / Morphology / Histology
         Animal Biochemistry
         Organic Chemistry
      image:
      isPartOf:
         name:Journal of Bioenergetics and Biomembranes
         issn:
            1573-6881
            0145-479X
         volumeNumber:38
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Cécile Batandier
            affiliation:
                  name:Universit Joseph Fourier
                  address:
                     name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bruno Guigas
            affiliation:
                  name:Universit Joseph Fourier
                  address:
                     name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dominique Detaille
            affiliation:
                  name:Universit Joseph Fourier
                  address:
                     name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. El-Mir
            affiliation:
                  name:University of Salamanca
                  address:
                     name:Faculty of Pharmacy, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eric Fontaine
            affiliation:
                  name:Universit Joseph Fourier
                  address:
                     name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Rigoulet
            affiliation:
                  name:Universit de Bordeaux II
                  address:
                     name:Institut de Biochimie et de Génétique Cellulaire de CNRS, Universit de Bordeaux II, Bordeaux Cedex, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:X. M. Leverve
            affiliation:
                  name:Universit Joseph Fourier
                  address:
                     name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
                     type:PostalAddress
                  type:Organization
                  name:Universit Joseph Fourier
                  address:
                     name:Bioénergétique Fondamentale et Appliquée INSERM E-0221, Universit Joseph Fourier, Grenoble Cedex, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Bioenergetics and Biomembranes
      issn:
         1573-6881
         0145-479X
      volumeNumber:38
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Universit Joseph Fourier
      address:
         name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
         type:PostalAddress
      name:Universit Joseph Fourier
      address:
         name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
         type:PostalAddress
      name:Universit Joseph Fourier
      address:
         name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
         type:PostalAddress
      name:University of Salamanca
      address:
         name:Faculty of Pharmacy, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
         type:PostalAddress
      name:Universit Joseph Fourier
      address:
         name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
         type:PostalAddress
      name:Universit de Bordeaux II
      address:
         name:Institut de Biochimie et de Génétique Cellulaire de CNRS, Universit de Bordeaux II, Bordeaux Cedex, France
         type:PostalAddress
      name:Universit Joseph Fourier
      address:
         name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
         type:PostalAddress
      name:Universit Joseph Fourier
      address:
         name:Bioénergétique Fondamentale et Appliquée INSERM E-0221, Universit Joseph Fourier, Grenoble Cedex, France
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Cécile Batandier
      affiliation:
            name:Universit Joseph Fourier
            address:
               name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
               type:PostalAddress
            type:Organization
      name:Bruno Guigas
      affiliation:
            name:Universit Joseph Fourier
            address:
               name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
               type:PostalAddress
            type:Organization
      name:Dominique Detaille
      affiliation:
            name:Universit Joseph Fourier
            address:
               name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
               type:PostalAddress
            type:Organization
      name:M. El-Mir
      affiliation:
            name:University of Salamanca
            address:
               name:Faculty of Pharmacy, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
               type:PostalAddress
            type:Organization
      name:Eric Fontaine
      affiliation:
            name:Universit Joseph Fourier
            address:
               name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
               type:PostalAddress
            type:Organization
      name:M. Rigoulet
      affiliation:
            name:Universit de Bordeaux II
            address:
               name:Institut de Biochimie et de Génétique Cellulaire de CNRS, Universit de Bordeaux II, Bordeaux Cedex, France
               type:PostalAddress
            type:Organization
      name:X. M. Leverve
      affiliation:
            name:Universit Joseph Fourier
            address:
               name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
               type:PostalAddress
            type:Organization
            name:Universit Joseph Fourier
            address:
               name:Bioénergétique Fondamentale et Appliquée INSERM E-0221, Universit Joseph Fourier, Grenoble Cedex, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
      name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
      name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
      name:Faculty of Pharmacy, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
      name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
      name:Institut de Biochimie et de Génétique Cellulaire de CNRS, Universit de Bordeaux II, Bordeaux Cedex, France
      name:INSERM E-0221 Bioénergétique Fondamentale et Appliquée, Universit Joseph Fourier, Grenoble, France
      name:Bioénergétique Fondamentale et Appliquée INSERM E-0221, Universit Joseph Fourier, Grenoble Cedex, France
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(147)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.82s.

LINK . SPRINGER . COM {}