We are analyzing https://link.springer.com/article/10.1007/s10863-005-8642-5.

Title:
ANT2 Isoform Required for Cancer Cell Glycolysis | Journal of Bioenergetics and Biomembranes
Description:
The three adenine nucleotide translocator ({ANT1} to {ANT3}) isoforms, differentially expressed in human cells, play a crucial role in cell bioenergetics by catalyzing ADP and ATP exchange across the mitochondrial inner membrane. In contrast to differentiated tissue cells, transformed cells, and their ρ0 derivatives, i.e. cells deprived of mitochondrial DNA, sustain a high rate of glycolysis. We compared the expression pattern of {ANT} isoforms in several transformed human cell lines at different stages of the cell cycle. The level of {ANT2} expression and glycolytic ATP production in these cell lines were in keeping with their metabolic background and their state of differentiation. The sensitivity of the mitochondrial inner membrane potential (Δψ) to several inhibitors of glycolysis and oxidative phosphorylation confirmed this relationship. We propose a new model for ATP uptake in cancer cells implicating the {ANT2} isoform, in conjunction with hexokinase II and the β subunit of mitochondrial ATP synthase, in the Δψ maintenance and in the aggressiveness of cancer cells.
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google, scholar, cas, article, biol, cell, chem, cancer, stepien, mitochondrial, ant, cells, chevrollier, loiseau, access, mol, france, privacy, cookies, content, journal, glycolysis, renier, douay, nelson, sci, usa, angers, publish, search, arnaud, dominique, chabi, gilles, olivier, yves, malthièry, georges, atp, exp, proc, natl, acad, res, wallace, data, information, log, research, bioenergetics,

Topics {✒️}

month download article/chapter adenine nucleotide translocator oxidative phosphorylation confirmed adenine nucleotide transporter privacy choices/manage cookies full article pdf mitochondrial atp synthase ant2 isoform required cancer cell glycolysis european economic area glycolytic suppression dramatically genome res van der meer service d' immunologie olivier douay conditions privacy policy glycolytic atp production intracellular metabolic profile differentiated tissue cells {ant2} expression cancer cells implicating colon cancer cells accepting optional cookies georges stepien béatrice chabi journal finder publish main content log article chevrollier article journal expression pattern mitochondrial dna mitochondrial swelling october 2005 volume 37 author correspondence check access instant access article log gene 254 cell lines {ant2} isoform article cite related subjects affiliations inserm privacy policy personal data biomembranes aims books a human cells transformed cells mitochondrial

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         headline:ANT2 Isoform Required for Cancer Cell Glycolysis
         description:The three adenine nucleotide translocator ({ANT1} to {ANT3}) isoforms, differentially expressed in human cells, play a crucial role in cell bioenergetics by catalyzing ADP and ATP exchange across the mitochondrial inner membrane. In contrast to differentiated tissue cells, transformed cells, and their ρ0 derivatives, i.e. cells deprived of mitochondrial DNA, sustain a high rate of glycolysis. We compared the expression pattern of {ANT} isoforms in several transformed human cell lines at different stages of the cell cycle. The level of {ANT2} expression and glycolytic ATP production in these cell lines were in keeping with their metabolic background and their state of differentiation. The sensitivity of the mitochondrial inner membrane potential (Δψ) to several inhibitors of glycolysis and oxidative phosphorylation confirmed this relationship. We propose a new model for ATP uptake in cancer cells implicating the {ANT2} isoform, in conjunction with hexokinase II and the β subunit of mitochondrial ATP synthase, in the Δψ maintenance and in the aggressiveness of cancer cells.
         datePublished:
         dateModified:
         pageStart:307
         pageEnd:317
         sameAs:https://doi.org/10.1007/s10863-005-8642-5
         keywords:
            Carcinogenesis
            mitochondria
            glycolysis
            adenine nucleotide translocator.
            Bioorganic Chemistry
            Biochemistry
            general
            Animal Anatomy / Morphology / Histology
            Animal Biochemistry
            Organic Chemistry
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ScholarlyArticle:
      headline:ANT2 Isoform Required for Cancer Cell Glycolysis
      description:The three adenine nucleotide translocator ({ANT1} to {ANT3}) isoforms, differentially expressed in human cells, play a crucial role in cell bioenergetics by catalyzing ADP and ATP exchange across the mitochondrial inner membrane. In contrast to differentiated tissue cells, transformed cells, and their ρ0 derivatives, i.e. cells deprived of mitochondrial DNA, sustain a high rate of glycolysis. We compared the expression pattern of {ANT} isoforms in several transformed human cell lines at different stages of the cell cycle. The level of {ANT2} expression and glycolytic ATP production in these cell lines were in keeping with their metabolic background and their state of differentiation. The sensitivity of the mitochondrial inner membrane potential (Δψ) to several inhibitors of glycolysis and oxidative phosphorylation confirmed this relationship. We propose a new model for ATP uptake in cancer cells implicating the {ANT2} isoform, in conjunction with hexokinase II and the β subunit of mitochondrial ATP synthase, in the Δψ maintenance and in the aggressiveness of cancer cells.
      datePublished:
      dateModified:
      pageStart:307
      pageEnd:317
      sameAs:https://doi.org/10.1007/s10863-005-8642-5
      keywords:
         Carcinogenesis
         mitochondria
         glycolysis
         adenine nucleotide translocator.
         Bioorganic Chemistry
         Biochemistry
         general
         Animal Anatomy / Morphology / Histology
         Animal Biochemistry
         Organic Chemistry
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