We are analyzing https://link.springer.com/article/10.1007/s10815-011-9644-3.

Title:
Sperm transcriptome profiling in oligozoospermia | Journal of Assisted Reproduction and Genetics
Description:
Purpose Investigate in what extent sperm transcriptome of infertile men is different from that of fertile individuals. Methods Semen samples were collected for determination of sperm parameters as well as for RNA isolation. Gene expression profile was investigated in spermatozoa of 8 infertile and 3 fertile men by microarray analysis using the Affymetrix Chip HG-U133 Plus 2.0. Result(s) We observed up to 33-fold reduction expression of genes involved in spermatogenesis and sperm motility. Furthermore, there is an important decrease in expression of genes involved in DNA repair as well as oxidative stress regulation. In this study, we also show a striking drop in expression of histone modification genes. Conclusion(s) We found that transcription profile in germ cells of men with idiopathic infertility is different from that of fertile individuals. Interestingly, about 15% of the regulated genes (Eddy Rev Reprod 4:23–30, 1999) play a role in spermatogenesis.
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Keywords {🔍}

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Topics {✒️}

male factor infertility idiopathic male infertility month download article/chapter human sperm transcripts spermatozoal rna profiles affymetrix chip hg-u133 protein tpd52l3/hd55 interacts a-kinase anchoring protein gene expression profile gene products organized spermatozoal gene expression idiopathic infertility sperm transcriptome profiling spermatozoal rna profiling microarray analysis full article pdf histone modification genes author information authors de la grange privacy choices/manage cookies sperm flagellar genes related subjects differential transcriptomic profile 33-fold reduction expression heat shock proteins human ciliary axonemes translational research department testis-specific differential rna fingerprinting delivering spermatozoan rna extent sperm transcriptome check access instant access curated protein family article montjean oligoasthenoteratozoospermic sperm patients genome res human ejaculate spermatozoa mol biol cell nucleic acids res adult male european economic area paul cohen-bacrie oxidative stress regulation understanding molecular aspects platts ae carrell dt thomas pd full-length cdna folia histochem cytobiol

Questions {❓}

A novel genomic diagnostic tool for sperm quality?
Mutations in the protamine locus: association with spermatogenic failure?

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