We are analyzing https://link.springer.com/article/10.1007/s10719-023-10102-1.

Title:
Fluorescent GD2 analog for single-molecule imaging | Glycoconjugate Journal
Description:
Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Non-Profit & Charity
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

article, pubmed, google, scholar, cas, ishida, ando, ganglioside, singlemolecule, tanaka, imamura, cell, imaging, suzuki, chem, fluorescent, komura, synthesis, biol, central, content, data, information, research, interactions, nat, kgn, kiso, privacy, cookies, journal, gangliosides, nature, grant, authors, springer, publish, search, published, january, yamaguchi, membranes, lipid, raft, access, membrane, total, japan, author, gifu,

Topics {✒️}

sophie groux-degroote p-tert-butyl groups improve month download article/chapter single-molecule imaging fluorescent gd2 analog gpi-anchored receptor breast cancer cells developed fluorescent analogs fluorescent ganglioside gd3 elucidating molecular interactions lipid raft formation lipid raft organization université de lille called lipid rafts disialoganglioside gd2 expression full article pdf privacy choices/manage cookies fluorescent ganglioside related subjects glyco-core research 2023 raft-based interactions raft-based interactions synthesized analog revealed aromatic protecting groups membrane protein regulation raft-philic character sialic acid dependence author information authors holds exclusive rights journal finder publish published article european economic area late-stage sialylation fluorescently labeled galnac applied bioorganic chemistry studies involving humans accepted manuscript version membrane molecules mobile conditions privacy policy electronic supplementary material article yamaguchi revitalizing membrane rafts hide-nori tanaka additional information publisher accepting optional cookies core program grant cell plasma membranes fluorescently labeled ssea-3 funding organizations listed hannover medical school

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Fluorescent GD2 analog for single-molecule imaging
         description:Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.
         datePublished:2023-01-26T00:00:00Z
         dateModified:2023-01-26T00:00:00Z
         pageStart:247
         pageEnd:257
         sameAs:https://doi.org/10.1007/s10719-023-10102-1
         keywords:
            Lipid raft
            Single-molecule imaging
            Ganglioside
            GD2
            Biochemistry
            general
            Pathology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Sch1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Sch2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Sch3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Fig2_HTML.png
         isPartOf:
            name:Glycoconjugate Journal
            issn:
               1573-4986
               0282-0080
            volumeNumber:40
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Eriko Yamaguchi
               affiliation:
                     name:Gifu University
                     address:
                        name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Naoko Komura
               affiliation:
                     name:Gifu University
                     address:
                        name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Hide-Nori Tanaka
               affiliation:
                     name:Gifu University
                     address:
                        name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Akihiro Imamura
               affiliation:
                     name:Gifu University
                     address:
                        name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
                     name:Gifu University
                     address:
                        name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hideharu Ishida
               affiliation:
                     name:Gifu University
                     address:
                        name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
                     name:Gifu University
                     address:
                        name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sophie Groux-Degroote
               affiliation:
                     name:CNRS, Université de Lille
                     address:
                        name:UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CNRS, Université de Lille, Lille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Martina Mühlenhoff
               affiliation:
                     name:Hannover Medical School
                     address:
                        name:Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kenichi G. N. Suzuki
               affiliation:
                     name:Gifu University
                     address:
                        name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Hiromune Ando
               affiliation:
                     name:Gifu University
                     address:
                        name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Fluorescent GD2 analog for single-molecule imaging
      description:Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.
      datePublished:2023-01-26T00:00:00Z
      dateModified:2023-01-26T00:00:00Z
      pageStart:247
      pageEnd:257
      sameAs:https://doi.org/10.1007/s10719-023-10102-1
      keywords:
         Lipid raft
         Single-molecule imaging
         Ganglioside
         GD2
         Biochemistry
         general
         Pathology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Sch1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Sch2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Sch3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10719-023-10102-1/MediaObjects/10719_2023_10102_Fig2_HTML.png
      isPartOf:
         name:Glycoconjugate Journal
         issn:
            1573-4986
            0282-0080
         volumeNumber:40
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Eriko Yamaguchi
            affiliation:
                  name:Gifu University
                  address:
                     name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Naoko Komura
            affiliation:
                  name:Gifu University
                  address:
                     name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Hide-Nori Tanaka
            affiliation:
                  name:Gifu University
                  address:
                     name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Akihiro Imamura
            affiliation:
                  name:Gifu University
                  address:
                     name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
                  name:Gifu University
                  address:
                     name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hideharu Ishida
            affiliation:
                  name:Gifu University
                  address:
                     name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
                  name:Gifu University
                  address:
                     name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sophie Groux-Degroote
            affiliation:
                  name:CNRS, Université de Lille
                  address:
                     name:UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CNRS, Université de Lille, Lille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Martina Mühlenhoff
            affiliation:
                  name:Hannover Medical School
                  address:
                     name:Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kenichi G. N. Suzuki
            affiliation:
                  name:Gifu University
                  address:
                     name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Hiromune Ando
            affiliation:
                  name:Gifu University
                  address:
                     name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Glycoconjugate Journal
      issn:
         1573-4986
         0282-0080
      volumeNumber:40
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Gifu University
      address:
         name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
         type:PostalAddress
      name:Gifu University
      address:
         name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
         type:PostalAddress
      name:Gifu University
      address:
         name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
         type:PostalAddress
      name:Gifu University
      address:
         name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
         type:PostalAddress
      name:Gifu University
      address:
         name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
         type:PostalAddress
      name:Gifu University
      address:
         name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
         type:PostalAddress
      name:Gifu University
      address:
         name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
         type:PostalAddress
      name:CNRS, Université de Lille
      address:
         name:UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CNRS, Université de Lille, Lille, France
         type:PostalAddress
      name:Hannover Medical School
      address:
         name:Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
         type:PostalAddress
      name:Gifu University
      address:
         name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
         type:PostalAddress
      name:Gifu University
      address:
         name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Eriko Yamaguchi
      affiliation:
            name:Gifu University
            address:
               name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
      name:Naoko Komura
      affiliation:
            name:Gifu University
            address:
               name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Hide-Nori Tanaka
      affiliation:
            name:Gifu University
            address:
               name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
      name:Akihiro Imamura
      affiliation:
            name:Gifu University
            address:
               name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
            name:Gifu University
            address:
               name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
      name:Hideharu Ishida
      affiliation:
            name:Gifu University
            address:
               name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
            name:Gifu University
            address:
               name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
      name:Sophie Groux-Degroote
      affiliation:
            name:CNRS, Université de Lille
            address:
               name:UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CNRS, Université de Lille, Lille, France
               type:PostalAddress
            type:Organization
      name:Martina Mühlenhoff
      affiliation:
            name:Hannover Medical School
            address:
               name:Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
               type:PostalAddress
            type:Organization
      name:Kenichi G. N. Suzuki
      affiliation:
            name:Gifu University
            address:
               name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Hiromune Ando
      affiliation:
            name:Gifu University
            address:
               name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
      name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
      name:Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan
      name:UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CNRS, Université de Lille, Lille, France
      name:Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
      name:Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(129)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.59s.

LINK . SPRINGER . COM {}