LINK . SPRINGER . COM {}

Matching Content Categories {📚}

• Education
• Science
• Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,603,474 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

article, google, scholar, cancer, cas, carcinoma, acid, esophageal, retinoic, receptor, signaling, cell, pathway, rarα, chen, xiamen, wntβcatenin, zhang, kinase, knockdown, shen, china, privacy, cookies, content, data, research, expression, related, drug, squamous, resistance, publish, search, manuscript, mao, hua, liu, proliferation, cells, mmp, phosphorylation, access, nat, mol, pubmed, oncogenic, wnt, sci, biol,

Topics {✒️}

promoting β-catenin phosphorylation/degradation wnt/β-catenin signaling pathway wnt/β-catenin pathway month download article/chapter enhanced drug susceptibility gsk3β/β-catenin pathway gsk3beta/beta-catenin signaling retinoic acid receptors wnt/beta-catenin pathways dong-yan shen qing-xi chen gsk3alpha exhibits beta-catenin cerebral ischemia-induced neurogenesis nuclear receptor superfamily qian-en chen activates wnt pathway article digestive diseases lymph node metastasis reduces akt signaling retinoic acid colorectal carcinoma inhibits wif-1 expression full article pdf privacy choices/manage cookies akt/nf-kappab rarα knockdown suppressed rarα knockdown inhibited jin-xing shen tumor suppressor human ec tissues xiao-yun zhang nat rev cancer huang gl tau protein kinase article mao acute promyelocytic leukemia nat cell biol wnt signaling ethics declarations conflict drosophila shaggy kinase inhibiting p38 phosphorylation related subjects natural science foundation mol cell biol european economic area check access epithelial-mesenchymal transition living kidney donors positive feedback loop tumour biol

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Retinoic Acid Receptor α Knockdown Suppresses the Tumorigenicity of Esophageal Carcinoma via Wnt/β-catenin Pathway
         description:Aberrant expression of retinoic acid receptor α (RARα) was correlated with diverse carcinomas such as acute promyelocytic leukemia and colorectal carcinoma. Nevertheless, the function and mechanism of RARα in esophageal carcinoma (EC) remain unclear. To investigate the expression of RARα in EC and its effect in the tumorigenesis of EC. In immunohistochemistry study, RARα was overexpressed in human EC tissues, and its overexpression was closely related to the pathological differentiation, lymph node metastasis, and clinical stages in EC patients. Functionally, RARα knockdown suppressed the proliferation and metastasis of EC cells through downregulating the expression of PCNA, Ki67, MMP7, and MMP9, as well as enhanced drug susceptibility of EC cells to 5-fluorouracil and cisplatin. Mechanistically, RARα knockdown inhibited the activity of Wnt/β-catenin pathway through reducing the phosphorylation level of GSK3β at Ser-9 and inducing phosphorylation level at Tyr-216, which resulted in downregulation of its downstream targets such as MMP7, MMP9, and P-gP. Our results demonstrated that RARα knockdown suppressed the tumorigenicity of EC via Wnt/β-catenin pathway. RARα might be a potential molecular target for EC clinical therapy.
         datePublished:2018-08-28T00:00:00Z
         dateModified:2018-08-28T00:00:00Z
         pageStart:3348
         pageEnd:3358
         sameAs:https://doi.org/10.1007/s10620-018-5254-6
         keywords:
            Retinoic acid receptor α
            Esophageal carcinoma
            Proliferation
            Metastasis
            Drug susceptibility
            Wnt/β-catenin pathway
            Gastroenterology
            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig5_HTML.png
         isPartOf:
            name:Digestive Diseases and Sciences
            issn:
               1573-2568
               0163-2116
            volumeNumber:63
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Xiao-Mei Mao
               affiliation:
                     name:Xiamen University
                     address:
                        name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hua Li
               affiliation:
                     name:The First Affiliated Hospital of Xiamen University
                     address:
                        name:Department of Gastroenterology, The First Affiliated Hospital of Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiao-Yun Zhang
               affiliation:
                     name:The First Affiliated Hospital of Xiamen University
                     address:
                        name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pan Zhou
               affiliation:
                     name:Xiamen University
                     address:
                        name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qi-Rui Fu
               affiliation:
                     name:Xiamen University
                     address:
                        name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qian-En Chen
               affiliation:
                     name:Xiamen University
                     address:
                        name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jin-Xing Shen
               affiliation:
                     name:The First Affiliated Hospital of Xiamen University
                     address:
                        name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yu Liu
               affiliation:
                     name:The First Affiliated Hospital of Xiamen University
                     address:
                        name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qing-Xi Chen
               affiliation:
                     name:Xiamen University
                     address:
                        name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Dong-Yan Shen
               affiliation:
                     name:The First Affiliated Hospital of Xiamen University
                     address:
                        name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Retinoic Acid Receptor α Knockdown Suppresses the Tumorigenicity of Esophageal Carcinoma via Wnt/β-catenin Pathway
      description:Aberrant expression of retinoic acid receptor α (RARα) was correlated with diverse carcinomas such as acute promyelocytic leukemia and colorectal carcinoma. Nevertheless, the function and mechanism of RARα in esophageal carcinoma (EC) remain unclear. To investigate the expression of RARα in EC and its effect in the tumorigenesis of EC. In immunohistochemistry study, RARα was overexpressed in human EC tissues, and its overexpression was closely related to the pathological differentiation, lymph node metastasis, and clinical stages in EC patients. Functionally, RARα knockdown suppressed the proliferation and metastasis of EC cells through downregulating the expression of PCNA, Ki67, MMP7, and MMP9, as well as enhanced drug susceptibility of EC cells to 5-fluorouracil and cisplatin. Mechanistically, RARα knockdown inhibited the activity of Wnt/β-catenin pathway through reducing the phosphorylation level of GSK3β at Ser-9 and inducing phosphorylation level at Tyr-216, which resulted in downregulation of its downstream targets such as MMP7, MMP9, and P-gP. Our results demonstrated that RARα knockdown suppressed the tumorigenicity of EC via Wnt/β-catenin pathway. RARα might be a potential molecular target for EC clinical therapy.
      datePublished:2018-08-28T00:00:00Z
      dateModified:2018-08-28T00:00:00Z
      pageStart:3348
      pageEnd:3358
      sameAs:https://doi.org/10.1007/s10620-018-5254-6
      keywords:
         Retinoic acid receptor α
         Esophageal carcinoma
         Proliferation
         Metastasis
         Drug susceptibility
         Wnt/β-catenin pathway
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-018-5254-6/MediaObjects/10620_2018_5254_Fig5_HTML.png
      isPartOf:
         name:Digestive Diseases and Sciences
         issn:
            1573-2568
            0163-2116
         volumeNumber:63
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Xiao-Mei Mao
            affiliation:
                  name:Xiamen University
                  address:
                     name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hua Li
            affiliation:
                  name:The First Affiliated Hospital of Xiamen University
                  address:
                     name:Department of Gastroenterology, The First Affiliated Hospital of Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiao-Yun Zhang
            affiliation:
                  name:The First Affiliated Hospital of Xiamen University
                  address:
                     name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pan Zhou
            affiliation:
                  name:Xiamen University
                  address:
                     name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qi-Rui Fu
            affiliation:
                  name:Xiamen University
                  address:
                     name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qian-En Chen
            affiliation:
                  name:Xiamen University
                  address:
                     name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jin-Xing Shen
            affiliation:
                  name:The First Affiliated Hospital of Xiamen University
                  address:
                     name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yu Liu
            affiliation:
                  name:The First Affiliated Hospital of Xiamen University
                  address:
                     name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qing-Xi Chen
            affiliation:
                  name:Xiamen University
                  address:
                     name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Dong-Yan Shen
            affiliation:
                  name:The First Affiliated Hospital of Xiamen University
                  address:
                     name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Digestive Diseases and Sciences
      issn:
         1573-2568
         0163-2116
      volumeNumber:63
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Xiamen University
      address:
         name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
         type:PostalAddress
      name:The First Affiliated Hospital of Xiamen University
      address:
         name:Department of Gastroenterology, The First Affiliated Hospital of Xiamen University, Xiamen, China
         type:PostalAddress
      name:The First Affiliated Hospital of Xiamen University
      address:
         name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
         type:PostalAddress
      name:Xiamen University
      address:
         name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
         type:PostalAddress
      name:Xiamen University
      address:
         name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
         type:PostalAddress
      name:Xiamen University
      address:
         name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
         type:PostalAddress
      name:The First Affiliated Hospital of Xiamen University
      address:
         name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
         type:PostalAddress
      name:The First Affiliated Hospital of Xiamen University
      address:
         name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
         type:PostalAddress
      name:Xiamen University
      address:
         name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
         type:PostalAddress
      name:The First Affiliated Hospital of Xiamen University
      address:
         name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Xiao-Mei Mao
      affiliation:
            name:Xiamen University
            address:
               name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Hua Li
      affiliation:
            name:The First Affiliated Hospital of Xiamen University
            address:
               name:Department of Gastroenterology, The First Affiliated Hospital of Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Xiao-Yun Zhang
      affiliation:
            name:The First Affiliated Hospital of Xiamen University
            address:
               name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Pan Zhou
      affiliation:
            name:Xiamen University
            address:
               name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Qi-Rui Fu
      affiliation:
            name:Xiamen University
            address:
               name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Qian-En Chen
      affiliation:
            name:Xiamen University
            address:
               name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Jin-Xing Shen
      affiliation:
            name:The First Affiliated Hospital of Xiamen University
            address:
               name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Yu Liu
      affiliation:
            name:The First Affiliated Hospital of Xiamen University
            address:
               name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      name:Qing-Xi Chen
      affiliation:
            name:Xiamen University
            address:
               name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Dong-Yan Shen
      affiliation:
            name:The First Affiliated Hospital of Xiamen University
            address:
               name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
      name:Department of Gastroenterology, The First Affiliated Hospital of Xiamen University, Xiamen, China
      name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
      name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
      name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
      name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
      name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
      name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
      name:Key Lab of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen, China
      name:Department of Biobank, The First Affiliated Hospital of Xiamen University, Xiamen, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(107)

• How much does https://www.springernature.com/gp/authors rake in every month?
• How much income is https://link.springernature.com/home/ earning monthly?
• https://order.springer.com/public/cart income
• What's the financial gain of https://submission.springernature.com/new-submission/10620/3?
• Learn how profitable https://www.springernature.com/gp/librarians/licensing/agc/journals is on a monthly basis
• How much does https://doi.org/10.3322%2Fcaac.21262 gross monthly?
• Profit of http://scholar.google.com/scholar_lookup?&title=Global%20cancer%20statistics%2C%202012&journal=CA%20Cancer%20J%20Clin&doi=10.3322%2Fcaac.21262&volume=65&pages=87-108&publication_year=2015&author=Torre%2CLA&author=Bray%2CF&author=Siegel%2CRL&author=Ferlay%2CJ&author=Lortet-Tieulent%2CJ&author=Jemal%2CA
• What's the financial outcome of https://doi.org/10.3322%2Fcaac.21338?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Cancer%20statistics%20in%20China%2C%202015&journal=CA%20Cancer%20J%20Clin&doi=10.3322%2Fcaac.21338&volume=66&pages=115-132&publication_year=2016&author=Chen%2CW&author=Zheng%2CR&author=Baade%2CPD?
• How much does https://doi.org/10.1136%2Fgutjnl-2014-308124 pull in monthly?
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Global%20incidence%20of%20oesophageal%20cancer%20by%20histological%20subtype%20in%202012&journal=Gut&doi=10.1136%2Fgutjnl-2014-308124&volume=64&pages=381-387&publication_year=2015&author=Arnold%2CM&author=Soerjomataram%2CI&author=Ferlay%2CJ&author=Forman%2CD
• https://doi.org/10.1056%2FNEJMoa1408932's total income per month
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Gestational%20hypertension%20and%20preeclampsia%20in%20living%20kidney%20donors&journal=N%20Engl%20J%20Med&doi=10.1056%2FNEJMoa1408932&volume=372&pages=1469-1470&publication_year=2015&author=Garg%2CAX&author=McArthur%2CE&author=Lentine%2CKL bring in?
• How much revenue does https://doi.org/10.1038%2Fnrc2773 bring in?
• Get to know http://scholar.google.com/scholar_lookup?&title=Barrett%E2%80%99s%20oesophagus%20and%20oesophageal%20adenocarcinoma%3A%20time%20for%20a%20new%20synthesis&journal=Nat%20Rev%20Cancer&doi=10.1038%2Fnrc2773&volume=10&pages=87-101&publication_year=2010&author=Reid%2CBJ&author=Li%2CX&author=Galipeau%2CPC&author=Vaughan%2CTL's earnings
• Financial intake of https://doi.org/10.1038%2Fnrd1551
• How much does http://scholar.google.com/scholar_lookup?&title=Principles%20for%20modulation%20of%20the%20nuclear%20receptor%20superfamily&journal=Nat%20Rev%20Drug%20Discov&doi=10.1038%2Fnrd1551&volume=3&pages=950-964&publication_year=2004&author=Gronemeyer%2CH&author=Gustafsson%2CJA&author=Laudet%2CV pull in?
• https://doi.org/10.1016%2Fj.mam.2014.12.003 income
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Retinoic%20acid%20receptors%3A%20from%20molecular%20mechanisms%20to%20cancer%20therapy&journal=Mol%20Asp%20Med&doi=10.1016%2Fj.mam.2014.12.003&volume=41&pages=1-115&publication_year=2015&author=Masi%2CA&author=Leboffe%2CL&author=Marinis%2CE?
• How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8562957 generate?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=The%20t%285%3B17%29%20variant%20of%20acute%20promyelocytic%20leukemia%20expresses%20a%20nucleophosmin-retinoic%20acid%20receptor%20fusion&journal=Blood&volume=87&pages=882-886&publication_year=1996&author=Redner%2CRLRE&author=Faas%2CS?
• What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26045816?
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440125 generate monthly?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Clinicopathological%20significance%20of%20wnt%2F%CE%B2-catenin%20signaling%20pathway%20in%20esophageal%20squamous%20cell%20carcinoma&journal=Int%20J%20Clin%20Exp%20Pathol&volume=8&pages=3045-3053&publication_year=2015&author=Deng%2CFYZK&author=Cui%2CWL&author=Liu%2CD&author=Ma%2CYQ?
• https://doi.org/10.1002%2Fmc.22277 income
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Kruppel-like%20factor%209%20was%20down-regulated%20in%20esophageal%20squamous%20cell%20carcinoma%20and%20negatively%20regulated%20beta-catenin%2FTCF%20signaling&journal=Mol%20Carcinog&doi=10.1002%2Fmc.22277&volume=55&pages=280-291&publication_year=2016&author=Qiao%2CF&author=Yao%2CF&author=Chen%2CL
• How much revenue does https://doi.org/10.1371%2Fjournal.pone.0084944 produce monthly?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Dickkopf-1%20is%20oncogenic%20and%20involved%20in%20invasive%20growth%20in%20non%20small%20cell%20lung%20cancer&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0084944&volume=8&publication_year=2013&author=Li%2CS&author=Qin%2CX&author=Guo%2CX each month?
• How profitable is https://doi.org/10.1111%2Fcas.12296?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=HOTAIR%2C%20a%20prognostic%20factor%20in%20esophageal%20squamous%20cell%20carcinoma%2C%20inhibits%20WIF-1%20expression%20and%20activates%20Wnt%20pathway&journal=Cancer%20Sci&doi=10.1111%2Fcas.12296&volume=104&pages=1675-1682&publication_year=2013&author=Ge%2CXS&author=Ma%2CHJ&author=Zheng%2CXH?
• Monthly income for https://doi.org/10.1016%2Fj.phrs.2015.03.010
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Glycogen%20synthase%20kinase-3%20beta%20%28GSK-3beta%29%20signaling%3A%20implications%20for%20Parkinson%E2%80%99s%20disease&journal=Pharmacol%20Res&doi=10.1016%2Fj.phrs.2015.03.010&volume=97&pages=16-26&publication_year=2015&author=Golpich%2CM&author=Amini%2CE&author=Hemmati%2CF?
• How much profit does https://doi.org/10.1016%2Fj.tibs.2009.10.002 generate?
• Profit of http://scholar.google.com/scholar_lookup?&title=GSK3%3A%20a%20multifaceted%20kinase%20in%20Wnt%20signaling&journal=Trends%20Biochem%20Sci&doi=10.1016%2Fj.tibs.2009.10.002&volume=35&pages=161-168&publication_year=2010&author=Wu%2CD&author=Pan%2CW
• What are the earnings of https://doi.org/10.1038%2Fncb1508?
• Income figures for http://scholar.google.com/scholar_lookup?&title=A%20Wnt%E2%80%93Axin2%E2%80%93GSK3beta%20cascade%20regulates%20Snail1%20activity%20in%20breast%20cancer%20cells&journal=Nat%20Cell%20Biol&doi=10.1038%2Fncb1508&volume=8&pages=1398-1406&publication_year=2006&author=Yook%2CJI&author=Li%2CXY&author=Ota%2CI
• How much does https://doi.org/10.1016%2Fj.canlet.2016.11.038 bring in each month?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Oncogenic%20retinoic%20acid%20receptor%20alpha%20promotes%20human%20colorectal%20cancer%20growth%20through%20simultaneously%20regulating%20p21%20transcription%20and%20GSK3beta%2Fbeta-catenin%20signaling&journal=Cancer%20Lett&doi=10.1016%2Fj.canlet.2016.11.038&volume=388&pages=118-129&publication_year=2017&author=Huang%2CGL&author=Zhang%2CW&author=Ren%2CHY?
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351665 gross monthly?
• What's the income of http://scholar.google.com/scholar_lookup?&title=Positive%20feedback%20loop%20of%20IL-1%CE%B2%2FAkt%2FRAR%CE%B1%2FAkt%20signaling%20mediates%20oncogenic%20property%20of%20RAR%CE%B1%20in%20gastric%20carcinoma&journal=Oncotarget&volume=8&pages=6718-6729&publication_year=2016&author=Ren%2CHY&author=Liu%2CF&author=Huang%2CGL&author=Liu%2CY&author=Shen%2CJX&author=Zhou%2CP&author=Liu%2CWM&author=Shen%2CDY?
• What's the profit of https://doi.org/10.3748%2Fwjg.v21.i4.1148?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=%CE%B2-escin%20reverses%20multidrug%20resistance%20through%20inhibition%20of%20the%20GSK3%CE%B2%2F%CE%B2-catenin%20pathway%20in%20cholangiocarcinoma&journal=World%20J%20Gastroenterol&doi=10.3748%2Fwjg.v21.i4.1148&volume=21&pages=1148-1157&publication_year=2015&author=Huang%2CGL&author=Shen%2CDY&author=Cai%2CCF&author=Zhang%2CQY&author=Ren%2CHY&author=Chen%2CQX generate?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Diagnosis%20and%20surveillance%20of%20Barrett%E2%80%99s%20esophagus%3A%20addressing%20the%20transatlantic%20divide&journal=Dig%20Dis%20Sci&doi=10.1007%2Fs10620-016-4138-x&volume=61&pages=2185-2193&publication_year=2016&author=Ghaus%2CS&author=Neumann%2CH&author=Muhammad%2CH&author=Tontini%2CGE&author=Ishaq%2CS is on a monthly basis
• What's the profit of https://doi.org/10.1074%2Fjbc.M206402200?
• Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Wnt%20signaling%20protects%203T3-L1%20preadipocytes%20from%20apoptosis%20through%20induction%20of%20insulin-like%20growth%20factors&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M206402200&volume=277&pages=38239-38244&publication_year=2002&author=Longo%2CKA&author=Kennell%2CJA&author=Ochocinska%2CMJ&author=Ross%2CSE&author=Wright%2CWS&author=MacDougald%2COA
• How much profit is https://doi.org/10.1128%2FMCB.00384-13 making per month?
• How much does http://scholar.google.com/scholar_lookup?&title=Oncogenic%20activity%20of%20retinoic%20acid%20receptor%20gamma%20is%20exhibited%20through%20activation%20of%20the%20Akt%2FNF-kappaB%20and%20Wnt%2Fbeta-catenin%20pathways%20in%20cholangiocarcinoma&journal=Mol%20Cell%20Biol&doi=10.1128%2FMCB.00384-13&volume=33&pages=3416-3425&publication_year=2013&author=Huang%2CGL&author=Luo%2CQ&author=Rui%2CG earn?
• https://doi.org/10.1038%2Fncomms3175's financial summary
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Retinoic%20acid%20receptor%20alpha%20is%20associated%20with%20tamoxifen%20resistance%20in%20breast%20cancer&journal=Nat%20Commun&doi=10.1038%2Fncomms3175&volume=4&publication_year=2013&author=Johansson%2CHJ&author=Sanchez%2CBC&author=Mundt%2CF generate?
• Get to know https://doi.org/10.1016%2Fj.cell.2009.04.043's earnings
• How much does http://scholar.google.com/scholar_lookup?&title=Genomic%20antagonism%20between%20retinoic%20acid%20and%20estrogen%20signaling%20in%20breast%20cancer&journal=Cell&doi=10.1016%2Fj.cell.2009.04.043&volume=137&pages=1259-1271&publication_year=2009&author=Hua%2CS&author=Kittler%2CR&author=White%2CKP rake in every month?
• What is the earnings of https://doi.org/10.1053%2Fj.gastro.2015.08.025?
• See how much http://scholar.google.com/scholar_lookup?&title=Nuclear%20localization%20of%20DNAJB6%20is%20associated%20with%20survival%20of%20patients%20with%20esophageal%20cancer%20and%20reduces%20AKT%20signaling%20and%20proliferation%20of%20cancer%20cells&journal=Gastroenterology&doi=10.1053%2Fj.gastro.2015.08.025&volume=149&pages=1825-1836&publication_year=2015&author=Yu%2CVZ&author=Wong%2CVC&author=Dai%2CW makes per month
• How much money does https://doi.org/10.2174%2F156802610792928103 generate?
• Get to know http://scholar.google.com/scholar_lookup?&title=Reversal%20of%20multidrug%20resistance%20by%20natural%20substances%20from%20plants&journal=Curr%20Top%20Med%20Chem&doi=10.2174%2F156802610792928103&volume=10&pages=1757-1768&publication_year=2010&author=Moln%C3%A1r%2CJEH&author=Hohmann%2CJ&author=Moln%C3%A1r%2CP&author=Deli%2CJ&author=Wesolowska%2CO&author=Michalak%2CK&author=Wang%2CQ's earnings
• How much money does http://scholar.google.com/scholar_lookup?&title=Caveolin-1%20affects%20tumor%20drug%20resistance%20in%20esophageal%20squamous%20cell%20carcinoma%20by%20regulating%20expressions%20of%20P-gp%20and%20MRP1&journal=Tumour%20Biol&doi=10.1007%2Fs13277-015-4778-z&volume=37&pages=9189-9196&publication_year=2016&author=Zhang%2CS&author=Cao%2CW&author=Yue%2CM generate?
• What's the revenue for https://doi.org/10.5732%2Fcjc.009.10599?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Expression%20and%20significance%20of%20tumor%20drug%20resistance%20related%20proteins%20and%20catenin%20in%20esophageal%20squamous%20cell%20carcinoma&journal=Chin%20J%20Cancer&doi=10.5732%2Fcjc.009.10599&volume=29&pages=300-305&publication_year=2009&author=Gan%2CSY&author=Zhong%2CXY&author=Xie%2CSM&author=Li%2CSM&author=Peng%2CH&author=Luo%2CF?
• What's the total monthly financial gain of https://doi.org/10.1046%2Fj.1471-4159.2002.00918.x?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Alternative%20splicing%20isoform%20of%20tau%20protein%20kinase%20I%2Fglycogen%20synthase%20kinase%203beta&journal=J%20Neurochem&doi=10.1046%2Fj.1471-4159.2002.00918.x&volume=81&pages=1073-1083&publication_year=2002&author=Mukai%2CFIK&author=Sano%2CY?
• How profitable is https://doi.org/10.1038%2F362557a0?
• How much does http://scholar.google.com/scholar_lookup?&title=Drosophila%20shaggy%20kinase%20and%20rat%20glycogen%20synthase%20kinase-3%20have%20conserved%20activities%20and%20act%20downstream%20of%20Notch&journal=Nature&doi=10.1038%2F362557a0&volume=362&pages=557-560&publication_year=1993&author=Ruel%2CLBM&author=Heitzler%2CP earn?
• How much revenue does https://doi.org/10.1111%2Fj.1460-9568.2006.05243.x produce monthly?
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=GSK3alpha%20exhibits%20beta-catenin%20and%20tau%20directed%20kinase%20activities%20that%20are%20modulated%20by%20Wnt&journal=Eur%20J%20Neurosci&doi=10.1111%2Fj.1460-9568.2006.05243.x&volume=24&pages=3387-3392&publication_year=2006&author=Asuni%2CAA&author=Hooper%2CC&author=Reynolds%2CCH&author=Lovestone%2CS&author=Anderton%2CBH&author=Killick%2CR?
• How much revenue does https://doi.org/10.1038%2Fleu.2012.2 bring in?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=GSK3%20is%20a%20regulator%20of%20RAR-mediated%20differentiation&journal=Leukemia&doi=10.1038%2Fleu.2012.2&volume=26&pages=1277-1285&publication_year=2012&author=Gupta%2CK&author=Gulen%2CF&author=Sun%2CL?
• http://scholar.google.com/scholar_lookup?&title=Involvement%20of%20GSK-3beta%20phosphorylation%20through%20PI3-K%2FAkt%20in%20cerebral%20ischemia-induced%20neurogenesis%20in%20rats&journal=Mol%20Neurobiol&doi=10.1007%2Fs12035-016-0290-8&volume=54&pages=7917-7927&publication_year=2017&author=Kisoh%2CK&author=Hayashi%2CH&author=Itoh%2CT's revenue stream
• Financial intake of https://citation-needed.springer.com/v2/references/10.1007/s10620-018-5254-6?format=refman&flavour=references
• Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Xiao-Mei%20Mao
• Earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Xiao-Mei%20Mao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hua%20Li's total income per month
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hua%20Li%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• See how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Xiao-Yun%20Zhang makes per month
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Xiao-Yun%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
• What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pan%20Zhou?
• How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pan%20Zhou%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
• What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Qi-Rui%20Fu?
• How much profit is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Qi-Rui%20Fu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en making per month?
• How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Qian-En%20Chen generate?
• Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Qian-En%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jin-Xing%20Shen's gross income?
• What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jin-Xing%20Shen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yu%20Liu
• What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yu%20Liu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Qing-Xi%20Chen make?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Qing-Xi%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dong-Yan%20Shen?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dong-Yan%20Shen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• What's the monthly money flow for https://s100.copyright.com/AppDispatchServlet?title=Retinoic%20Acid%20Receptor%20%CE%B1%20Knockdown%20Suppresses%20the%20Tumorigenicity%20of%20Esophageal%20Carcinoma%20via%20Wnt%2F%CE%B2-catenin%20Pathway&author=Xiao-Mei%20Mao%20et%20al&contentID=10.1007%2Fs10620-018-5254-6©right=Springer%20Science%2BBusiness%20Media%2C%20LLC%2C%20part%20of%20Springer%20Nature&publication=0163-2116&publicationDate=2018-08-28&publisherName=SpringerNature&orderBeanReset=true?
• How much cash flow does https://crossmark.crossref.org/dialog/?doi=10.1007/s10620-018-5254-6 have monthly?
• How much does https://citation-needed.springer.com/v2/references/10.1007/s10620-018-5254-6?format=refman&flavour=citation net monthly?
• What's the monthly income of https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral?
• Income figures for https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research
• Earnings of https://www.springernature.com/gp/products
• What's the revenue for https://www.springernature.com/gp/librarians?
• How much cash flow does https://www.springernature.com/gp/societies have monthly?
• How profitable is https://www.springernature.com/gp/partners?
• What is the earnings of https://www.springer.com/?
• Find out how much https://www.nature.com/ earns monthly
• How much does https://www.biomedcentral.com/ net monthly?
• Find out how much https://www.palgrave.com/ earns monthly
• See how much https://www.apress.com/ makes per month
• Discover the revenue of https://www.springernature.com/gp/legal/ccpa
• How much does https://www.springernature.com/gp/info/accessibility make?
• What's the monthly money flow for https://support.springernature.com/en/support/home?
• How much does https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations earn?
• Revenue of https://www.springernature.com/

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Clipboard.js
• Prism.js

CDN Services {📦}

• Crossref