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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
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We are analyzing https://link.springer.com/article/10.1007/s10620-015-3909-0.

Title:
Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma | Digestive Diseases and Sciences
Description:
Esophageal adenocarcinoma is a male-dominant disease, but the role of androgens is unclear. To examine the expression and clinical correlates of the androgen receptor (AR) and the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma. Expression of AR and FKBP5 was determined by immunohistochemistry. The effect of the AR ligand 5α-dihydrotestosterone (DHT) on the expression of a panel of androgen-responsive genes was measured in AR-positive and AR-negative esophageal adenocarcinoma cell lines. Correlations in expression between androgen-responsive genes were analyzed in an independent cohort of esophageal adenocarcinoma tissues. There was AR staining in 75 of 77 cases (97 %), and FKBP5 staining in 49 (64 %), all of which had nuclear AR. Nuclear AR with FKBP5 expression was associated with decreased median survival (451 vs. 2800 days) and was an independent prognostic indicator (HR 2.894, 95 % CI 1.396–6.002, p = 0.0043) in multivariable Cox proportional hazards models. DHT induced a significant increase in expression of the androgen-responsive genes FKBP5, HMOX1, FBXO32, VEGFA, WNT5A, and KLK3 only in AR-positive cells in vitro. Significant correlations in expression were observed between these androgen-responsive genes in an independent cohort of esophageal adenocarcinoma tissues. Nuclear AR and expression of FKBP5 is associated with decreased survival in esophageal adenocarcinoma.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 8,150,568 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, adenocarcinoma, androgen, central, fkbp, prostate, esophageal, expression, receptor, cell, androgenresponsive, oesophageal, research, genes, adelaide, smith, access, australia, gene, cells, esophagus, university, woodville, privacy, cookies, content, analysis, independent, prognostic, eric, protein, receptors, res, growth, author, hospital, supplementary, material, data, information, publish, search, palethorpe, ruszkiewicz, leach,

Topics {✒️}

amino/carboxyl interaction-deficient variants fk506-binding protein 51 month download article/chapter castration-resistant prostate cancer androgen receptor-mediated regulation article digestive diseases central polypurine tract ar ligand 5α-dihydrotestosterone androgen-responsive gene fkbp5 full article pdf androgen-responsive genes fkbp5 androgen receptors sp1 binding site article smith privacy choices/manage cookies eric smith prostate cancer cells prostate cancer development primary cell cultures distal enhancer element poor prognosis translational health research neoplastic prostate epithelium androgen-responsive genes related subjects hum gene ther negatively regulating akt cell death dis independent prognostic indicators independent prognostic indicator mol cell endocrinol endocr relat cancer androgen-regulated genes esophageal adenocarcinoma cells dihydrotestosterone-inducible dickkopf 1 activate responsive sites esophageal adenocarcinoma tissues esophageal adenocarcinoma identified sex steroid hormones pka signaling pathways androgen receptor expression bmc cancer european economic area male-dominant disease male predominance due 17 year delayed development long-range activation distal intronic enhancers promoter dna methylation lentivirus vectors encoding

Questions {❓}

  • Androgens in endometrial carcinoma: the killer or helper?
  • Oesophageal adenocarcinoma: the new epidemic in men?
  • Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?

Schema {🗺️}

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         headline:Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma
         description:Esophageal adenocarcinoma is a male-dominant disease, but the role of androgens is unclear. To examine the expression and clinical correlates of the androgen receptor (AR) and the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma. Expression of AR and FKBP5 was determined by immunohistochemistry. The effect of the AR ligand 5α-dihydrotestosterone (DHT) on the expression of a panel of androgen-responsive genes was measured in AR-positive and AR-negative esophageal adenocarcinoma cell lines. Correlations in expression between androgen-responsive genes were analyzed in an independent cohort of esophageal adenocarcinoma tissues. There was AR staining in 75 of 77 cases (97 %), and FKBP5 staining in 49 (64 %), all of which had nuclear AR. Nuclear AR with FKBP5 expression was associated with decreased median survival (451 vs. 2800 days) and was an independent prognostic indicator (HR 2.894, 95 % CI 1.396–6.002, p = 0.0043) in multivariable Cox proportional hazards models. DHT induced a significant increase in expression of the androgen-responsive genes FKBP5, HMOX1, FBXO32, VEGFA, WNT5A, and KLK3 only in AR-positive cells in vitro. Significant correlations in expression were observed between these androgen-responsive genes in an independent cohort of esophageal adenocarcinoma tissues. Nuclear AR and expression of FKBP5 is associated with decreased survival in esophageal adenocarcinoma.
         datePublished:2015-10-14T00:00:00Z
         dateModified:2015-10-14T00:00:00Z
         pageStart:433
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         sameAs:https://doi.org/10.1007/s10620-015-3909-0
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            Androgen receptors
            FK506-binding protein 5
            Steroids
            Prognosis
            Gastroenterology
            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
            general
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      headline:Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma
      description:Esophageal adenocarcinoma is a male-dominant disease, but the role of androgens is unclear. To examine the expression and clinical correlates of the androgen receptor (AR) and the androgen-responsive gene FK506-binding protein 5 (FKBP5) in esophageal adenocarcinoma. Expression of AR and FKBP5 was determined by immunohistochemistry. The effect of the AR ligand 5α-dihydrotestosterone (DHT) on the expression of a panel of androgen-responsive genes was measured in AR-positive and AR-negative esophageal adenocarcinoma cell lines. Correlations in expression between androgen-responsive genes were analyzed in an independent cohort of esophageal adenocarcinoma tissues. There was AR staining in 75 of 77 cases (97 %), and FKBP5 staining in 49 (64 %), all of which had nuclear AR. Nuclear AR with FKBP5 expression was associated with decreased median survival (451 vs. 2800 days) and was an independent prognostic indicator (HR 2.894, 95 % CI 1.396–6.002, p = 0.0043) in multivariable Cox proportional hazards models. DHT induced a significant increase in expression of the androgen-responsive genes FKBP5, HMOX1, FBXO32, VEGFA, WNT5A, and KLK3 only in AR-positive cells in vitro. Significant correlations in expression were observed between these androgen-responsive genes in an independent cohort of esophageal adenocarcinoma tissues. Nuclear AR and expression of FKBP5 is associated with decreased survival in esophageal adenocarcinoma.
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      dateModified:2015-10-14T00:00:00Z
      pageStart:433
      pageEnd:443
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         Adenocarcinoma of the esophagus
         Androgen receptors
         FK506-binding protein 5
         Steroids
         Prognosis
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
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                  name:The University of Adelaide
                  address:
                     name:Solid Cancer Regulation Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
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               name:Solid Cancer Regulation Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
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      email:[email protected]
      name:Helen M. Palethorpe
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            name:The University of Adelaide
            address:
               name:Solid Cancer Regulation Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
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      name:Damien A. Leach
      affiliation:
            name:The University of Adelaide
            address:
               name:Cancer Biology Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
               type:PostalAddress
            type:Organization
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            name:University of Southampton
            address:
               name:Cancer Sciences Unit, Somers Cancer Research Building, Southampton General Hospital, University of Southampton, Southampton, UK
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      name:Eleanor F. Need
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            name:The University of Adelaide
            address:
               name:Breast Biology and Cancer Unit, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
               type:PostalAddress
            type:Organization
      name:Paul A. Drew
      affiliation:
            name:The University of Adelaide
            address:
               name:Solid Cancer Regulation Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
               type:PostalAddress
            type:Organization
            name:Flinders University
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               name:School of Nursing and Midwifery, Flinders University, Adelaide, Australia
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            type:Organization
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      name:Solid Cancer Regulation Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
      name:Solid Cancer Regulation Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
      name:Gastroenterology Research Laboratory, SA Pathology, Adelaide, Australia
      name:Data Management and Analysis Centre, Royal Adelaide Hospital, The University of Adelaide, Adelaide, Australia
      name:Cancer Biology Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
      name:Cancer Sciences Unit, Somers Cancer Research Building, Southampton General Hospital, University of Southampton, Southampton, UK
      name:Breast Biology and Cancer Unit, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
      name:Solid Cancer Regulation Group, Discipline of Surgery, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, The University of Adelaide, Woodville South, Australia
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External Links {🔗}(172)

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Libraries {📚}

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