We are analyzing https://link.springer.com/article/10.1007/s10620-015-3823-5.

Title:
Serum 25-Hydroxyvitamin D Levels and the Risk of Dysplasia and Esophageal Adenocarcinoma in Patients with Barrett’s Esophagus | Digestive Diseases and Sciences
Description:
To date, there are no studies reporting an association between vitamin D and Barrett’s esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. Patients from our BE Registry cohort seen between 2000 and 2012 who had serum 25(OH)D levels measured were included. Age, gender, race, BE length, hiatal hernia size, and histological findings were recorded. Patients without high-grade dysplasia (HGD)/EAC at or within 1 year of index biopsy and who had follow-up endoscopies and 25(OH)D levels were studied for incidence of dysplasia/EAC. Among 429 patients with BE, the mean 25(OH)D level was 72 ± 31.2 nmol/L. Hundred and one (23.6 %) patients had deficiency (<50 nmol/L), 149 (34.7 %) had insufficiency (50–74.9 nmol/L), and 179 (41.7 %) had normal levels of 25(OH)D. There was no association between serum 25(OH)D levels and dysplasia (p = 0.90). In the incidence cohort of 246 patients with median follow-up of 46 months, there were 34 cases of low-grade dysplasia, 12 of HGD, and 5 of EAC. Change in 25(OH)D levels did not impact progression to dysplasia/EAC (every 5 nmol/L increase from baseline, hazard ratio 0.98; p = 0.62). Serum 25(OH)D levels were low in 58.3 % of our BE cohort. There was no association between 25(OH)D levels and prevalence or incidence of HGD/EAC in patients with BE. Further long-term studies are needed to study the association between vitamin D status and progression of dysplasia in BE.
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article, cancer, google, scholar, pubmed, vitamin, cas, levels, serum, study, data, risk, hydroxyvitamin, esophageal, patients, ohd, dysplasia, manuscript, association, incidence, epidemiol, cleveland, analysis, adenocarcinoma, barretts, esophagus, thota, cohort, prospective, calcium, colorectal, privacy, cookies, content, prashanthi, studies, prev, interpretation, usa, publish, search, kistangari, singh, cummings, nmoll, access, mortality, oesophageal, nature, biomark,

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month download article/chapter article digestive diseases pooled case-control study italian case-control study full article pdf privacy choices/manage cookies oesophageal adenocarcinoma mol cell endocrinol cancer prev res european economic area hiatal hernia size eosinophilic esophagitis severity related subjects alters preneoplastic features national academies press ordonez-mena jm long-term variation rocio lopez ms final draft submitted ethics declarations conflict article prashanthi natl cancer inst dietary reference intakes ann intern med long-term studies esophageal squamous dysplasia quantitative health sciences gaurav kistangari md high-grade dysplasia bmc cancer conditions privacy policy author information authors accepting optional cookies ambient ultraviolet radiation selected micronutrient intake physicians’ health study oesophageal article log metabolism phosphorus updated meta-analysis prospective cohort studies journal finder publish low-grade dysplasia breast cancer patients usa prashanthi article cite cohort consortium vitamin prabhdeep singh & madhusudhan kaveh hajifathalian

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         headline:Serum 25-Hydroxyvitamin D Levels and the Risk of Dysplasia and Esophageal Adenocarcinoma in Patients with Barrett’s Esophagus
         description:To date, there are no studies reporting an association between vitamin D and Barrett’s esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. Patients from our BE Registry cohort seen between 2000 and 2012 who had serum 25(OH)D levels measured were included. Age, gender, race, BE length, hiatal hernia size, and histological findings were recorded. Patients without high-grade dysplasia (HGD)/EAC at or within 1 year of index biopsy and who had follow-up endoscopies and 25(OH)D levels were studied for incidence of dysplasia/EAC. Among 429 patients with BE, the mean 25(OH)D level was 72 ± 31.2 nmol/L. Hundred and one (23.6 %) patients had deficiency (<50 nmol/L), 149 (34.7 %) had insufficiency (50–74.9 nmol/L), and 179 (41.7 %) had normal levels of 25(OH)D. There was no association between serum 25(OH)D levels and dysplasia (p = 0.90). In the incidence cohort of 246 patients with median follow-up of 46 months, there were 34 cases of low-grade dysplasia, 12 of HGD, and 5 of EAC. Change in 25(OH)D levels did not impact progression to dysplasia/EAC (every 5 nmol/L increase from baseline, hazard ratio 0.98; p = 0.62). Serum 25(OH)D levels were low in 58.3 % of our BE cohort. There was no association between 25(OH)D levels and prevalence or incidence of HGD/EAC in patients with BE. Further long-term studies are needed to study the association between vitamin D status and progression of dysplasia in BE.
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            Biochemistry
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      description:To date, there are no studies reporting an association between vitamin D and Barrett’s esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. Patients from our BE Registry cohort seen between 2000 and 2012 who had serum 25(OH)D levels measured were included. Age, gender, race, BE length, hiatal hernia size, and histological findings were recorded. Patients without high-grade dysplasia (HGD)/EAC at or within 1 year of index biopsy and who had follow-up endoscopies and 25(OH)D levels were studied for incidence of dysplasia/EAC. Among 429 patients with BE, the mean 25(OH)D level was 72 ± 31.2 nmol/L. Hundred and one (23.6 %) patients had deficiency (<50 nmol/L), 149 (34.7 %) had insufficiency (50–74.9 nmol/L), and 179 (41.7 %) had normal levels of 25(OH)D. There was no association between serum 25(OH)D levels and dysplasia (p = 0.90). In the incidence cohort of 246 patients with median follow-up of 46 months, there were 34 cases of low-grade dysplasia, 12 of HGD, and 5 of EAC. Change in 25(OH)D levels did not impact progression to dysplasia/EAC (every 5 nmol/L increase from baseline, hazard ratio 0.98; p = 0.62). Serum 25(OH)D levels were low in 58.3 % of our BE cohort. There was no association between 25(OH)D levels and prevalence or incidence of HGD/EAC in patients with BE. Further long-term studies are needed to study the association between vitamin D status and progression of dysplasia in BE.
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         25-Hydroxyvitamin D levels
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         Gastroenterology
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         Transplant Surgery
         Biochemistry
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