We are analyzing https://link.springer.com/article/10.1007/s10620-009-1051-6.

Title:
Down-Regulation of miR-27a Might Reverse Multidrug Resistance of Esophageal Squamous Cell Carcinoma | Digestive Diseases and Sciences
Description:
Background So far, the miRNAs involved in multidrug resistance of esophageal cancer have not been reported. Aims and Methods Here we have firstly investigated the roles of miR-27a in multidrug resistance of esophageal squamous cell carcinoma using MTT assay, flow cytometry assay, and reporter gene assay, etc. Results Down-regulation of miR-27a could confer sensitivity of both P-glycoprotein-related and P-glycoprotein-non-related drugs on esophageal cancer cells, and might promote ADR-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of ADR. Down-regulation of miR-27a could significantly decrease the expression of P-glycoprotein, Bcl-2, and the transcription of the multidrug resistance gene 1, but up-regulate the expression of Bax. Conclusions MiR-27a might play important roles in multidrug resistance of esophageal cancer. The further study of the biological functions of miR-27a might be helpful for developing possible strategies to treat esophageal cancer.
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article, cas, pubmed, google, scholar, cancer, resistance, cell, multidrug, mira, esophageal, microrna, carcinoma, squamous, han, hong, cells, zhang, expression, privacy, cookies, content, liu, access, information, publish, search, downregulation, hongwei, apoptosis, bcl, res, regulation, gastric, data, log, journal, research, digestive, diseases, december, mengbin, assay, pglycoprotein, functions, adenocarcinoma, targeting, subjects, discover, biol,

Topics {✒️}

month download article/chapter squamous cell carcinoma promote adr-induced apoptosis esophageal cancer cells article digestive diseases treat esophageal cancer full article pdf induce mitochondrial apoptosis privacy choices/manage cookies gastric cancer cells del principe mi nat cell biol biochem cell biol cell biol int reverse multidrug resistance mediates multidrug resistance regulates intrahepatic metastasis mol cancer ther japanese male subjects microrna-27a functions mitochondrial apoptotic machinery clin cancer res dig dis sci conclusions mir-27a esophageal cancer gastric mucosal atrophy znrd1 mediates resistance european economic area mirnas involved decreased releasing amount zinc ribbon domain national scientific foundation microrna biogenesis pathways p-glycoprotein-related conditions privacy policy flow cytometry assay reporter gene assay chronic lymphocytic leukemia acute myeloid leukemia expressed microrna-27a molecular targeted drugs article zhang author information authors check access instant access suppressing p-glycoprotein p-glycoprotein mrp accepting optional cookies related subjects play important roles

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         description:So far, the miRNAs involved in multidrug resistance of esophageal cancer have not been reported. Here we have firstly investigated the roles of miR-27a in multidrug resistance of esophageal squamous cell carcinoma using MTT assay, flow cytometry assay, and reporter gene assay, etc. Down-regulation of miR-27a could confer sensitivity of both P-glycoprotein-related and P-glycoprotein-non-related drugs on esophageal cancer cells, and might promote ADR-induced apoptosis, accompanied by increased accumulation and decreased releasing amount of ADR. Down-regulation of miR-27a could significantly decrease the expression of P-glycoprotein, Bcl-2, and the transcription of the multidrug resistance gene 1, but up-regulate the expression of Bax. MiR-27a might play important roles in multidrug resistance of esophageal cancer. The further study of the biological functions of miR-27a might be helpful for developing possible strategies to treat esophageal cancer.
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