We are analyzing https://link.springer.com/article/10.1007/s10585-022-10172-9.

Title:
Understanding the cell survival mechanism of anoikis-resistant cancer cells during different steps of metastasis | Clinical & Experimental Metastasis
Description:
Anchorage-independent survival of cancer cells is associated with metastasis as it enables cells to travel to secondary target sites. Tissue integrity is generally maintained by detachment-induced cell death called ‘anoikis’, but cancer cells undergoing the multistep metastatic process show resistance to anoikis. Anoikis resistance enables these cells to survive through the extracellular matrix (ECM) deprived phase, which starts when cancer cells detach and move into the circulation till cells reach to the secondary target site. Comprehensive analysis of the molecular and functional biology of anoikis resistance in cancer cells will provide crucial details about cancer metastasis, enabling us to identify novel therapeutic targets against cancer cell dissemination and ultimately secondary tumor formation. This review broadly summarizes recent advances in the understanding of cellular and molecular events leading to anoikis and anoikis resistance. It further elaborates more about the signaling cross-talk in anoikis resistance and its regulation during metastasis.
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Keywords {🔍}

cancer, cells, google, scholar, cell, metastasis, cas, anoikis, tumor, resistance, circulating, breast, stem, transition, apoptosis, signaling, invasion, epithelialmesenchymal, protein, role, matrix, pathway, integrin, expression, autophagy, research, article, survival, metastatic, growth, emt, promotes, death, adhesion, human, platelets, khan, factor, tumour, activation, inhibition, bcl, implications, immune, author, malik, extracellular, mechanisms, pancreatic, progression,

Topics {✒️}

stk11/lkb1-mediated ampk pathway platelet-derived tgf-β1 mediates cis-pd-l1/cd80 interactions inhibiting platelet-derived cox-1/thromboxane sameer ullah khan upar/integrin β1/src signaling il-17a-induced mmp-3 expression triple-negative breast cancer integrin-regulated fak–src signaling platelet-derived growth factor‐ erk/bcl-2-mediated anti-apoptosis survivin-3b promotes chemoresistance interleukin-17a induces cathepsin mitogen-activated protein kinases myeloid-derived suppressor cells celecoxib-blocked prostaglandin e2 inflammation-induced cell migration month download article/chapter pd-1/pd-l1 axis cancer cell intravasation cell-matrix adhesion fatty acid β-oxidation acidic-adapted melanoma cells colon cancer relapse/metastasis aspirin blocks formation inducing epithelial–mesenchymal transition ampk-pea15 axis cancer cell adhesion anoikis-resistant cancer cells pi3k/akt pathway alterations death-receptor-related lung cancer cells transforming growth factor protein profiles circulating tumour cell csir-srf budget head circulating tumor cells impaired natural killer platelet-induced enhancement prostate cancer metastasis human breast cancer circulating cancer cells cancer cell invasion author information authors fayaz malik anti-β1 integrin cd44+/cd24-stem cancer cell dissemination bcl-2 dependent manner human ovarian cancer

Questions {❓}

Rennebeck G, Martelli M, Kyprianou NJCr (2005) Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis?
Tormoen GW et al (2012) Do circulating tumor cells play a role in coagulation and thrombosis?
Wojtukiewicz MZ et al (2017) Antiplatelet agents for cancer treatment: a real perspective or just an echo from the past?

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