We are analyzing https://link.springer.com/article/10.1007/s10585-011-9384-x.

Title:
Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature | Clinical & Experimental Metastasis
Description:
Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of the biological characteristics and behaviour of metastatic OS cells may provide a rational basis for innovative treatment strategies. The aim of this review is to give an overview of the biological changes in metastatic OS cells and the preclinical and clinical efforts targeting the different steps in OS metastases and how these contribute to designing a metastasis directed treatment for OS.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

cells, article, google, scholar, pubmed, metastasis, osteosarcoma, metastatic, cas, cancer, metastases, tumour, survival, cell, lung, pathway, growth, patients, treatment, expression, preclinical, signalling, fas, cxcr, therapy, primary, activation, proliferation, clinical, resistance, inhibition, progression, factor, ezrin, res, target, apoptosis, human, disease, potential, immune, pathways, clin, bone, studies, important, dormant, pulmonary, tumours, receptor,

Topics {✒️}

full-length anti-ezrin construct inactive wnt/beta-catenin pathway wnt/β-catenin pathway resulted host-anti-tumour immune reaction anti-apoptotic gene bcl-xl ezrin-activated mapk/akt signalling targeted therapies article download pdf c-x-c-motif β4-integrin knockdown inhibits wnt/β-catenin antagonists membrane-cytoskeleton linker protein p53-deficient cells rely blocking wnt/lrp5 signaling membrane-cytoskeleton linker ezrin atr-mediated checkpoint signaling wnt/β-catenin pathway anti-apoptotic bcl-2 family g-protein coupled receptors open access ezrin-related β4-integrin extracellular-signal-regulating-kinase host cytotoxic t-lymphocytes liposomal mtp-pe improved pi3k/akt/mtor pathway fast-growing angiogenic phenotype pre-clinical work shows notch-inhibited cell lines β-catenin target genes interferon-alpha enhances sensitivity death-receptor-induced apoptosis nf-kappab-dependent pathways conventional high-grade osteosarcoma fas-induced cell death gh/igf-1 axis involvement anti-angiogenic factor endostatin /akt-mediated anoikis resistance specific src-kinase inhibitor receptor-mediated cell death establish cell–cell adhesions exert anti-tumour activity induce anti-proliferative signalling inhibiting src-pathway activation α5β1-integrin mediated activation privacy choices/manage cookies bone marrow cells high-grade conventional os effectively reduce size nf-κb survival pathway full access

Questions {❓}

Hynes RO (2003) Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?
In order to improve survival, the ultimate questions to be answered are: Why does OS metastasize, particularly to the lungs?
Jeanes A, Gottardi CJ, Yap AS (2008) Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature
         description:Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of the biological characteristics and behaviour of metastatic OS cells may provide a rational basis for innovative treatment strategies. The aim of this review is to give an overview of the biological changes in metastatic OS cells and the preclinical and clinical efforts targeting the different steps in OS metastases and how these contribute to designing a metastasis directed treatment for OS.
         datePublished:2011-04-02T00:00:00Z
         dateModified:2011-04-02T00:00:00Z
         pageStart:493
         pageEnd:503
         license:https://creativecommons.org/licenses/by-nc/2.0
         sameAs:https://doi.org/10.1007/s10585-011-9384-x
         keywords:
            Drug resistance
            Metastasis
            Osteosarcoma
            Therapy
            Cancer Research
            Biomedicine
            general
            Oncology
            Hematology
            Surgical Oncology
         image:
         isPartOf:
            name:Clinical & Experimental Metastasis
            issn:
               1573-7276
               0262-0898
            volumeNumber:28
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:J. PosthumaDeBoer
               affiliation:
                     name:VU University Medical Center
                     address:
                        name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. A. Witlox
               affiliation:
                     name:Westfries Gasthuis
                     address:
                        name:Department of Orthopaedic Surgery, Westfries Gasthuis, Hoorn, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:G. J. L. Kaspers
               affiliation:
                     name:VU University Medical Center
                     address:
                        name:Paediatric Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:B. J. van Royen
               affiliation:
                     name:VU University Medical Center
                     address:
                        name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:VU University Medical Center
                     address:
                        name:VU University Medical Center, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature
      description:Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of the biological characteristics and behaviour of metastatic OS cells may provide a rational basis for innovative treatment strategies. The aim of this review is to give an overview of the biological changes in metastatic OS cells and the preclinical and clinical efforts targeting the different steps in OS metastases and how these contribute to designing a metastasis directed treatment for OS.
      datePublished:2011-04-02T00:00:00Z
      dateModified:2011-04-02T00:00:00Z
      pageStart:493
      pageEnd:503
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s10585-011-9384-x
      keywords:
         Drug resistance
         Metastasis
         Osteosarcoma
         Therapy
         Cancer Research
         Biomedicine
         general
         Oncology
         Hematology
         Surgical Oncology
      image:
      isPartOf:
         name:Clinical & Experimental Metastasis
         issn:
            1573-7276
            0262-0898
         volumeNumber:28
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:J. PosthumaDeBoer
            affiliation:
                  name:VU University Medical Center
                  address:
                     name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. A. Witlox
            affiliation:
                  name:Westfries Gasthuis
                  address:
                     name:Department of Orthopaedic Surgery, Westfries Gasthuis, Hoorn, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:G. J. L. Kaspers
            affiliation:
                  name:VU University Medical Center
                  address:
                     name:Paediatric Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:B. J. van Royen
            affiliation:
                  name:VU University Medical Center
                  address:
                     name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:VU University Medical Center
                  address:
                     name:VU University Medical Center, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Clinical & Experimental Metastasis
      issn:
         1573-7276
         0262-0898
      volumeNumber:28
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:VU University Medical Center
      address:
         name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
         type:PostalAddress
      name:Westfries Gasthuis
      address:
         name:Department of Orthopaedic Surgery, Westfries Gasthuis, Hoorn, The Netherlands
         type:PostalAddress
      name:VU University Medical Center
      address:
         name:Paediatric Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands
         type:PostalAddress
      name:VU University Medical Center
      address:
         name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
         type:PostalAddress
      name:VU University Medical Center
      address:
         name:VU University Medical Center, Amsterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:J. PosthumaDeBoer
      affiliation:
            name:VU University Medical Center
            address:
               name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:M. A. Witlox
      affiliation:
            name:Westfries Gasthuis
            address:
               name:Department of Orthopaedic Surgery, Westfries Gasthuis, Hoorn, The Netherlands
               type:PostalAddress
            type:Organization
      name:G. J. L. Kaspers
      affiliation:
            name:VU University Medical Center
            address:
               name:Paediatric Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:B. J. van Royen
      affiliation:
            name:VU University Medical Center
            address:
               name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:VU University Medical Center
            address:
               name:VU University Medical Center, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
      name:Department of Orthopaedic Surgery, Westfries Gasthuis, Hoorn, The Netherlands
      name:Paediatric Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands
      name:Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
      name:VU University Medical Center, Amsterdam, The Netherlands

External Links {🔗}(260)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

AOS
Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.62s.

LINK . SPRINGER . COM {}