We are analyzing https://link.springer.com/article/10.1007/s10585-010-9305-4.

Title:
A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics | Clinical & Experimental Metastasis
Description:
Metastasis is the major cause of cancer mortality. We aimed to find a metastasis-prone signature for early stage mismatch-repair proficient sporadic colorectal cancer (CRC) patients for better prognosis and informed use of adjuvant chemotherapy. The genome-wide expression profiles of 82 age-, ethnicity- and tissue-matched patients and healthy controls were analyzed using the Affymetrix U133 Plus 2 array. Metastasis-negative patients have 5 years or more of follow-up. A 10 × 10 two-level nested cross-validation design was used with several families of classification models to identify the optimal predictor for metastasis. The best classification model yielded a 54 gene-set (74 probe sets) with an estimated prediction accuracy of 71%. The specificity, sensitivity, negative and positive predictive values of the signature are 0.88, 0.58, 0.84 and 0.65, respectively, indicating that the gene-set can improve prognosis for early stage sporadic CRC patients. These 54 genes, including node molecules YWHAB, MAP3K5, LMNA, APP, GNAQ, F3, NFATC2, and TGM2, integrate multiple bio-functions in various compartments into an intricate molecular network, suggesting that cell-wide perturbations are involved in metastasis transformation. Further, querying the `Connectivity Map’ with a subset (70%) of these genes shows that Gly-His-Lys and securinine could reverse the differential expressions of these genes significantly, suggesting that they have combinatorial therapeutic effect on the metastasis-prone patients. These two perturbagens promote wound-healing, extracellular matrix remodeling and macrophage activation thus highlighting the importance of these pathways in metastasis suppression for early-stage CRC.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,016 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

cancer, article, google, scholar, pubmed, cas, colorectal, metastasis, expression, gene, clin, research, signature, patients, access, singapore, colon, privacy, cookies, content, data, clinical, early, genes, connectivity, sci, usa, res, publish, search, metastasisprone, mismatchrepair, proficient, sporadic, hong, cheah, stage, map, therapeutic, open, cancers, oncol, proc, nat, nature, including, information, log, find, journal,

Topics {✒️}

genome-wide expression profiles phosphatidylinositol 3-kinase-akt-mammalian target early-stage crc month download article/chapter peh yean cheah colorectal cancer research microarray gene-expression data distal colorectal cancers integrate multiple bio-functions perturbagens promote wound-healing human tri-peptide ghk cell-wide perturbations extracellular matrix remodeling gene expression signature gene expression profiles adjuvant colon cancer optimal predictor gene expression signatures gene-expression signatures metastasis-prone patients full article pdf gene expression patterns `connectivity map connectivity map �metastasis-prone’ signature metastasis-prone signature promoter–enhancer connectivity cancer cooperative groups privacy choices/manage cookies metastasis-negative patients clinical data retrieval colon cancer estimated prediction accuracy proximal msi cancers tissue-matched patients check access instant access colorectal surgery article hong connect small molecules gene expression susceptibility gene set clinical research european economic area positive predictive values oxaliplatin/5fu/lv updated efficacy results primary solid tumors comparative lesion sequencing predominantly postmenopausal cohort

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics
         description:Metastasis is the major cause of cancer mortality. We aimed to find a metastasis-prone signature for early stage mismatch-repair proficient sporadic colorectal cancer (CRC) patients for better prognosis and informed use of adjuvant chemotherapy. The genome-wide expression profiles of 82 age-, ethnicity- and tissue-matched patients and healthy controls were analyzed using the Affymetrix U133 Plus 2 array. Metastasis-negative patients have 5 years or more of follow-up. A 10 × 10 two-level nested cross-validation design was used with several families of classification models to identify the optimal predictor for metastasis. The best classification model yielded a 54 gene-set (74 probe sets) with an estimated prediction accuracy of 71%. The specificity, sensitivity, negative and positive predictive values of the signature are 0.88, 0.58, 0.84 and 0.65, respectively, indicating that the gene-set can improve prognosis for early stage sporadic CRC patients. These 54 genes, including node molecules YWHAB, MAP3K5, LMNA, APP, GNAQ, F3, NFATC2, and TGM2, integrate multiple bio-functions in various compartments into an intricate molecular network, suggesting that cell-wide perturbations are involved in metastasis transformation. Further, querying the `Connectivity Map’ with a subset (70%) of these genes shows that Gly-His-Lys and securinine could reverse the differential expressions of these genes significantly, suggesting that they have combinatorial therapeutic effect on the metastasis-prone patients. These two perturbagens promote wound-healing, extracellular matrix remodeling and macrophage activation thus highlighting the importance of these pathways in metastasis suppression for early-stage CRC.
         datePublished:2010-02-09T00:00:00Z
         dateModified:2010-02-09T00:00:00Z
         pageStart:83
         pageEnd:90
         sameAs:https://doi.org/10.1007/s10585-010-9305-4
         keywords:
            Early stage colorectal cancer
            Genome-wide expression profiling
            Metastasis predictor
            Mismatch-repair proficient
            Connectivity map query
            Cancer Research
            Biomedicine
            general
            Oncology
            Hematology
            Surgical Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10585-010-9305-4/MediaObjects/10585_2010_9305_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10585-010-9305-4/MediaObjects/10585_2010_9305_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10585-010-9305-4/MediaObjects/10585_2010_9305_Fig3_HTML.gif
         isPartOf:
            name:Clinical & Experimental Metastasis
            issn:
               1573-7276
               0262-0898
            volumeNumber:27
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yi Hong
               affiliation:
                     name:Singapore General Hospital
                     address:
                        name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas Downey
               affiliation:
                     name:Partek Incorporated
                     address:
                        name:Partek Incorporated, St. Louis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kong Weng Eu
               affiliation:
                     name:Singapore General Hospital
                     address:
                        name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Poh Koon Koh
               affiliation:
                     name:Singapore General Hospital
                     address:
                        name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peh Yean Cheah
               affiliation:
                     name:Singapore General Hospital
                     address:
                        name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics
      description:Metastasis is the major cause of cancer mortality. We aimed to find a metastasis-prone signature for early stage mismatch-repair proficient sporadic colorectal cancer (CRC) patients for better prognosis and informed use of adjuvant chemotherapy. The genome-wide expression profiles of 82 age-, ethnicity- and tissue-matched patients and healthy controls were analyzed using the Affymetrix U133 Plus 2 array. Metastasis-negative patients have 5 years or more of follow-up. A 10 × 10 two-level nested cross-validation design was used with several families of classification models to identify the optimal predictor for metastasis. The best classification model yielded a 54 gene-set (74 probe sets) with an estimated prediction accuracy of 71%. The specificity, sensitivity, negative and positive predictive values of the signature are 0.88, 0.58, 0.84 and 0.65, respectively, indicating that the gene-set can improve prognosis for early stage sporadic CRC patients. These 54 genes, including node molecules YWHAB, MAP3K5, LMNA, APP, GNAQ, F3, NFATC2, and TGM2, integrate multiple bio-functions in various compartments into an intricate molecular network, suggesting that cell-wide perturbations are involved in metastasis transformation. Further, querying the `Connectivity Map’ with a subset (70%) of these genes shows that Gly-His-Lys and securinine could reverse the differential expressions of these genes significantly, suggesting that they have combinatorial therapeutic effect on the metastasis-prone patients. These two perturbagens promote wound-healing, extracellular matrix remodeling and macrophage activation thus highlighting the importance of these pathways in metastasis suppression for early-stage CRC.
      datePublished:2010-02-09T00:00:00Z
      dateModified:2010-02-09T00:00:00Z
      pageStart:83
      pageEnd:90
      sameAs:https://doi.org/10.1007/s10585-010-9305-4
      keywords:
         Early stage colorectal cancer
         Genome-wide expression profiling
         Metastasis predictor
         Mismatch-repair proficient
         Connectivity map query
         Cancer Research
         Biomedicine
         general
         Oncology
         Hematology
         Surgical Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10585-010-9305-4/MediaObjects/10585_2010_9305_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10585-010-9305-4/MediaObjects/10585_2010_9305_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10585-010-9305-4/MediaObjects/10585_2010_9305_Fig3_HTML.gif
      isPartOf:
         name:Clinical & Experimental Metastasis
         issn:
            1573-7276
            0262-0898
         volumeNumber:27
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yi Hong
            affiliation:
                  name:Singapore General Hospital
                  address:
                     name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Downey
            affiliation:
                  name:Partek Incorporated
                  address:
                     name:Partek Incorporated, St. Louis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kong Weng Eu
            affiliation:
                  name:Singapore General Hospital
                  address:
                     name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Poh Koon Koh
            affiliation:
                  name:Singapore General Hospital
                  address:
                     name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peh Yean Cheah
            affiliation:
                  name:Singapore General Hospital
                  address:
                     name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Clinical & Experimental Metastasis
      issn:
         1573-7276
         0262-0898
      volumeNumber:27
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Singapore General Hospital
      address:
         name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
         type:PostalAddress
      name:Partek Incorporated
      address:
         name:Partek Incorporated, St. Louis, USA
         type:PostalAddress
      name:Singapore General Hospital
      address:
         name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
         type:PostalAddress
      name:Singapore General Hospital
      address:
         name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
         type:PostalAddress
      name:Singapore General Hospital
      address:
         name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yi Hong
      affiliation:
            name:Singapore General Hospital
            address:
               name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Thomas Downey
      affiliation:
            name:Partek Incorporated
            address:
               name:Partek Incorporated, St. Louis, USA
               type:PostalAddress
            type:Organization
      name:Kong Weng Eu
      affiliation:
            name:Singapore General Hospital
            address:
               name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Poh Koon Koh
      affiliation:
            name:Singapore General Hospital
            address:
               name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Peh Yean Cheah
      affiliation:
            name:Singapore General Hospital
            address:
               name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
      name:Partek Incorporated, St. Louis, USA
      name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
      name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
      name:Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(99)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.6s.

LINK . SPRINGER . COM {}