We are analyzing https://link.springer.com/article/10.1007/s10577-006-1030-0.

Title:
Chromatin dynamics and the evolution of alternate promoter states | Chromosome Research
Description:
Eucaryotic gene transcriptional switches utilize changes both in the activity and composition of soluble transcription factor complexes, and epigenetic modifications to the chromatin template. Until recently, alternate states of promoter activity have been associated with the assembly of relatively stable multiprotein complexes on target genes, with transitions in the composition of these complexes occurring on the time scale of minutes or hours. The development of living cell techniques to characterize transcription factor function in real time has led to an alternate view of highly dynamic protein/template interactions. In addition, emerging evidence suggests that energy-dependent processes contribute significantly to the rapid movement of proteins in living cells, and to the exchange of sequence-specific DNA-binding proteins with regulatory elements. Potential mechanisms involved in the unexpectedly rapid flux of factor/template interactions are discussed in the context of a “return-to-template” model for transcription factor function.
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Keywords {🔍}

google, scholar, cas, pubmed, article, chromatin, transcription, cell, receptor, biol, hager, mol, dynamics, promoter, gene, receptors, glucocorticoid, science, remodeling, nuclear, elbi, nagaich, cells, research, transcriptional, factor, living, dynamic, proteins, steroid, factors, walker, curr, privacy, cookies, content, john, complexes, rapid, access, structure, estrogen, chem, cancer, function, publish, search, alternate, johnson, interactions,

Topics {✒️}

month download article/chapter sequence-specific dna-binding proteins yi qiu & sam john induced alpha-helix structure uv laser cross-linking pre-unfolding resonant oscillations nf-kappab transcription factor steroid–dependent hypersensitive region swi/snf chromatin remodeling regulatory elements saccharomyces cerevisiae snf2/swi2 estrogen receptor-regulated transcription related subjects atp-dependent nucleosome remodeling progesterone receptor-hsp90 complexes full article pdf regulated transcription factors gene expression privacy choices/manage cookies transcription factor dynamics n-terminal domains transcription factor function dynamic regulation signal-mediated transport factor/template interactions atp-dependent mobilization ligand specific dynamics steroid hormone receptors dynamic hp1 binding ligand-dependent interaction transcriptional state transcriptional activation transcription factors rapid periodic binding alternate promoter states p160 coactivator complexes glucocorticoid receptor requires smith cl stable multiprotein complexes nuclear hormone receptors gene targeting european economic area emerging evidence suggests potential mechanisms involved stable heterochromatin domains mammalian rna polymerase archer tk higher education press proteasome-mediated turnover mcnally jg

Questions {❓}

Margueron R, Trojer P, Reinberg D (2005) The key to development: interpreting the histone code?

Schema {🗺️}

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         description:Eucaryotic gene transcriptional switches utilize changes both in the activity and composition of soluble transcription factor complexes, and epigenetic modifications to the chromatin template. Until recently, alternate states of promoter activity have been associated with the assembly of relatively stable multiprotein complexes on target genes, with transitions in the composition of these complexes occurring on the time scale of minutes or hours. The development of living cell techniques to characterize transcription factor function in real time has led to an alternate view of highly dynamic protein/template interactions. In addition, emerging evidence suggests that energy-dependent processes contribute significantly to the rapid movement of proteins in living cells, and to the exchange of sequence-specific DNA-binding proteins with regulatory elements. Potential mechanisms involved in the unexpectedly rapid flux of factor/template interactions are discussed in the context of a “return-to-template” model for transcription factor function.
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            Plant Genetics and Genomics
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         Animal Genetics and Genomics
         Plant Genetics and Genomics
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