We are analyzing https://link.springer.com/article/10.1007/s10557-009-6209-0.

Title:
Resveratrol: A Multifunctional Compound Improving Endothelial Function | Cardiovascular Drugs and Therapy
Description:
The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively.
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Keywords {🔍}

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Topics {✒️}

article download pdf enhanced acetylcholine-induced relaxation streptozotocin-induced diabetic rats apolipoprotein e-deficient mice long-term resveratrol treatment major gender differences estrogen receptor erα-dependent sirt1-dependent enos upregulation sirt1-dependent enos deacetylation spontaneously hypertensive rats post-translational effects contribute resveratrol inhibits superoxide-mediated resveratrol decreases superoxide-mediated sirt1 deacetylates enos resveratrol-induced enos expression privacy choices/manage cookies vivo resveratrol supplementation improves endothelial responsiveness big ca2+-activated endothelium-dependent relaxation klinge cm endothelium-dependent vasorelaxation endothelium-dependent relaxations erk1/2-mediated enos phosphorylation antioxidatives gene products hypoxanthine/xanthine oxidase calorie restriction leads major risk factors human endothelial cells resveratrol-induced endothelial isolated rat aorta wine polyphenol resveratrol cardiovasc drug rev endothelial oxidative stress resveratrol increases endothelial metal-induced radicals [2] mitochondrial electron transport chronic resveratrol treatment stimulates enos activity alter enos levels exp biol med female rats fed red wine increases vascular oxidative stress cardiovasc drugs ther reactive oxygen species polyphenol phytoalexin present estrogen receptors alpha including white hellebore short-term treatment

Schema {🗺️}

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         headline:Resveratrol: A Multifunctional Compound Improving Endothelial Function
         description:The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively.
         datePublished:2009-11-25T00:00:00Z
         dateModified:2009-11-25T00:00:00Z
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      headline:Resveratrol: A Multifunctional Compound Improving Endothelial Function
      description:The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively.
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