We are analyzing https://link.springer.com/article/10.1007/s10555-018-9764-7.

Title:
Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases | Cancer and Metastasis Reviews
Description:
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) may represent the quintessential example of a moonlighting protein. The latter are a new, intriguing class of cell proteins which exhibit multiple activities in different subcellular locales apart from their initially, well-characterized function. As such, apart from its classical role in energy production, membrane-bound GAPDH is required for membrane fusion, endocytosis and, intriguingly, for iron transport. Cytoplasmic GAPDH regulates mRNA stability and is required for ER to Golgi trafficking. Nuclear GAPDH is involved in apoptosis, transcriptional gene regulation, the maintenance of DNA integrity, as well as nuclear tRNA export. Paradoxically, the etiology of a number of human pathologies is dependent upon GAPDH structure and function. In particular, recent evidence indicates a significant role for moonlighting GAPDH in tumorigenesis. Specifically, these include its role in the survival of tumor cells, in tumor angiogenesis, as well as its control of tumor cell gene expression and posttranscriptional regulation of tumor cell mRNA. Each of these activities correlates with increased tumor progression and, unfortunately, a poor prognosis for the afflicted individual.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, google, scholar, pubmed, cas, cancer, gapdh, glyceraldehydephosphate, dehydrogenase, cell, journal, human, research, cells, expression, factor, protein, role, regulation, moonlighting, sirover, nuclear, gene, tumor, biology, nature, privacy, cookies, function, content, apoptosis, access, biochemistry, ovarian, central, colonystimulating, information, publish, search, metastasis, transcriptional, death, rna, acta, hara, science, springer, data, log, progression,

Topics {✒️}

glyceraldehyde-3-phosphate dehydrogenase gene glyceraldehyde-3-phosphate dehydrogenase expression gapdh-siah1 stress-signaling cascade glyceraldehyde-3-phosphate dehydrogenase interacts month download article/chapter macrophage colony-stimulating factor mammalian glyceraldehyde-3-phosphate dehydrogenase moonlighting glyceraldehyde-3-phosphate dehydrogenase glyceraldehyde-3-phosphate dehydrogenase binds nitric oxide-gapdh-siah human glyceraldehyde-3-phosphate dehydrogenase article google scholar glyceraldehyde-3-phosphate dehydrogenase nf-κb-dependent induction colony-stimulating factor-1 d3 phosphoinositide-regulated kinases caspase-independent cell death tumor cell mrna molecular cancer research csf-1 posttranscriptional regulation transcriptional gene regulation full article pdf nature cell biology tumor angiogenesis hif-1 activity depending ovarian cancer cells privacy choices/manage cookies article cancer cell death cascade biophysical research communications messenger rna decay bmc res notes posttranscriptional regulation article sirover human urinary protein cancer research hypoxia-inducible factor 1 medical science quintessential moonlighting protein metastasis reviews aims related subjects quantifying rna levels mammalian o2 homeostasis phosphoinositide-dependent phosphorylation nuclear trna export gapdh mediates nitrosylation european economic area check access bcl-xl increase increased blood glucose

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases
         description:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) may represent the quintessential example of a moonlighting protein. The latter are a new, intriguing class of cell proteins which exhibit multiple activities in different subcellular locales apart from their initially, well-characterized function. As such, apart from its classical role in energy production, membrane-bound GAPDH is required for membrane fusion, endocytosis and, intriguingly, for iron transport. Cytoplasmic GAPDH regulates mRNA stability and is required for ER to Golgi trafficking. Nuclear GAPDH is involved in apoptosis, transcriptional gene regulation, the maintenance of DNA integrity, as well as nuclear tRNA export. Paradoxically, the etiology of a number of human pathologies is dependent upon GAPDH structure and function. In particular, recent evidence indicates a significant role for moonlighting GAPDH in tumorigenesis. Specifically, these include its role in the survival of tumor cells, in tumor angiogenesis, as well as its control of tumor cell gene expression and posttranscriptional regulation of tumor cell mRNA. Each of these activities correlates with increased tumor progression and, unfortunately, a poor prognosis for the afflicted individual.
         datePublished:2018-09-12T00:00:00Z
         dateModified:2018-09-12T00:00:00Z
         pageStart:665
         pageEnd:676
         sameAs:https://doi.org/10.1007/s10555-018-9764-7
         keywords:
            Glyceraldehyde-3-phosphate dehydrogenase
            Tumorigenesis
            Apoptosis
            Cancer angiogenesis
            Posttranscriptional mRNA regulation
            Cancer gene expression
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-018-9764-7/MediaObjects/10555_2018_9764_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-018-9764-7/MediaObjects/10555_2018_9764_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-018-9764-7/MediaObjects/10555_2018_9764_Fig3_HTML.png
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:37
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Michael A. Sirover
               affiliation:
                     name:Temple University
                     address:
                        name:Department of Pharmacology, The Lewis Katz School of Medicine, Temple University, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases
      description:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) may represent the quintessential example of a moonlighting protein. The latter are a new, intriguing class of cell proteins which exhibit multiple activities in different subcellular locales apart from their initially, well-characterized function. As such, apart from its classical role in energy production, membrane-bound GAPDH is required for membrane fusion, endocytosis and, intriguingly, for iron transport. Cytoplasmic GAPDH regulates mRNA stability and is required for ER to Golgi trafficking. Nuclear GAPDH is involved in apoptosis, transcriptional gene regulation, the maintenance of DNA integrity, as well as nuclear tRNA export. Paradoxically, the etiology of a number of human pathologies is dependent upon GAPDH structure and function. In particular, recent evidence indicates a significant role for moonlighting GAPDH in tumorigenesis. Specifically, these include its role in the survival of tumor cells, in tumor angiogenesis, as well as its control of tumor cell gene expression and posttranscriptional regulation of tumor cell mRNA. Each of these activities correlates with increased tumor progression and, unfortunately, a poor prognosis for the afflicted individual.
      datePublished:2018-09-12T00:00:00Z
      dateModified:2018-09-12T00:00:00Z
      pageStart:665
      pageEnd:676
      sameAs:https://doi.org/10.1007/s10555-018-9764-7
      keywords:
         Glyceraldehyde-3-phosphate dehydrogenase
         Tumorigenesis
         Apoptosis
         Cancer angiogenesis
         Posttranscriptional mRNA regulation
         Cancer gene expression
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-018-9764-7/MediaObjects/10555_2018_9764_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-018-9764-7/MediaObjects/10555_2018_9764_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-018-9764-7/MediaObjects/10555_2018_9764_Fig3_HTML.png
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:37
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michael A. Sirover
            affiliation:
                  name:Temple University
                  address:
                     name:Department of Pharmacology, The Lewis Katz School of Medicine, Temple University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:37
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Temple University
      address:
         name:Department of Pharmacology, The Lewis Katz School of Medicine, Temple University, Philadelphia, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Michael A. Sirover
      affiliation:
            name:Temple University
            address:
               name:Department of Pharmacology, The Lewis Katz School of Medicine, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pharmacology, The Lewis Katz School of Medicine, Temple University, Philadelphia, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(133)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.01s.

LINK . SPRINGER . COM {}