We are analyzing https://link.springer.com/article/10.1007/s10555-014-9542-0.

Title:
Immunotherapy of melanoma: Present options and future promises | Cancer and Metastasis Reviews
Description:
Metastatic melanoma is notorious for its immune evasion and resistance to conventional chemotherapy. The recent success of ipilimumab, a human monoclonal antibody against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), in increasing the median survival time and stabilizing the disease progression renewed, hopes in treatment for melanoma. Currently, ipilimumab and high-dose interleukin-2 (IL-2; Aldesleukin) are approved as monotherapies for the treatment of patients with unresectable advanced melanoma, and pegylated interferon-α2b (p-IFN-α2b) is approved as an adjuvant for the treatment of patients with surgically resected high-risk melanoma. The present review describes the currently approved immune-modulators and the promising immune-based interventions that are currently in clinical trials. We present the four commonly used strategies to boost immune responses against the tumors; monoclonal antibodies, cytokines, cancer vaccines, and adoptive T cell transfer. The corresponding lists of ongoing clinical trials include details of the trial phase, target patients, intervention details, status of the study, and expected date of completion. Further, our review discusses the challenges faced by immunotherapy and the various strategies adopted to overcome them.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, google, scholar, article, cas, melanoma, cancer, journal, clinical, immunotherapy, central, research, human, treatment, patients, therapy, ipilimumab, cell, oncology, advanced, medicine, doi, immunology, cells, metastatic, reviews, review, nature, immune, antibody, ctla, dois, tumor, doiccr, dendritic, privacy, cookies, content, present, rotte, zhou, monoclonal, survival, adjuvant, adoptive, trial, phase, access, gene, activation,

Topics {✒️}

granulocyte-macrophage colony-stimulating factor anti-programmed-death-receptor-1 treatment month download article/chapter b7-related molecule b7-h1 randomised dose-comparison cohort anti-ctla-4 antibody ipilimumab pegylated interferon alpha-2b human t-cell activation inhibitory b7-family molecules van der bruggen promising immune-based interventions immune based therapies immune-related adverse events pd1/pd-l1 axis full article pdf t-cell responses interferon alfa-2b human monoclonal antibody ipilimumab-refractory advanced melanoma high-dose interleukin-2 pegylated interferon-α2b privacy choices/manage cookies peginterferon-alfa-2b adoptive cell therapy targeting mapk pathway tumor-infiltrating cd8+ current gene therapy cancer consensus statement dermatologic adverse events cd27/cd70 pathway b7 family revisited main stumbling blocks severe adverse events localized stage progression ifn-gamma production targeting human cd27 adoptive cell immunotherapy van den eynde xenogeneic human tyrosinase cytotoxic t-lymphocyte biological rationale dermatological treatment human gene mage-1 durable tumor remission tumor-infiltrating lymphocytes costimulatory b7-h1 human vaccin immunotherapy nature reviews cancer drug administration approval cd27-expressing lymphoma

Questions {❓}

Psychological care for people with melanoma: what, when, why and how?
Psychological stress and melanoma: are we meeting our patients’ psychological needs?

Schema {🗺️}

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