We are analyzing https://link.springer.com/article/10.1007/s10555-011-9310-3.

Title:
Cyclooxygenases and lipoxygenases in cancer | Cancer and Metastasis Reviews
Description:
Cancer initiation and progression are multistep events that require cell proliferation, migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and ultimately secondary growth. Tumor cell functions at both primary or secondary sites are controlled by many different factors, including growth factors and their receptors, chemokines, nuclear receptors, cell–cell interactions, cell–matrix interactions, as well as oxygenated metabolites of arachidonic acid. The observation that cyclooxygenases and lipoxygenases and their arachidonic acid-derived eicosanoid products (prostanoids and HETEs) are expressed and produced by tumor cells, together with the finding that these enzymes can regulate cell growth, survival, migration, and invasion, has prompted investigators to analyze the roles of these enzymes in cancer progression. In this review, we focus on the contribution of cyclooxygenase- and lipoxygenase-derived eicosanoids to tumor cell function in vitro and in vivo and discuss hope and tribulations of targeting these enzymes for cancer prevention and treatment.
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Keywords {🔍}

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Topics {✒️}

peroxisome proliferator-activated receptor-γ n-aroyl-tetrahydro-gamma-carbolines acylnitroso hetero-diels-alder cycloadducts pgf2alpha-f-prostanoid receptor signalling ep4-betaarrestin1-c-src signalsome f-prostanoid receptor signalling extracellular signal-regulated kinases f-series-prostanoid receptor prostaglandin e-type receptor f-prostanoid receptor regulation linoleic acid-dependent growth pi3k-akt signalling pathways small-cell lung cancer month download article/chapter calcium-calcineurin-nfat pathway phospatidylinositol-3-kinase/akt ppar diminished lipocalin-type prostaglandin nuclear factor-kappab activation aspirin-triggered lipoxin a4 nonsteroidal anti-inflammatory drugs uv-induced skin carcinogenesis castration-resistant prostate cancer anti-inflammatory cyclopentenone prostaglandins vascular integrin alpha prostaglandin e2 results thromboxane synthase signaling c17-hydroxy acids catalyzed promotes cell proliferation ep4 receptor antagonist promotes adipocyte differentiation suppresses colon carcinogenesis prostaglandin-independent pathway structure-activity relationship studies ppar-gamma activity prostaglandin d2 receptor pge2 receptor ep2 anti-tumorigenic effects microvascular endothelial cells focal adhesion assembly lipocalin-type prostaglandin 5-lipoxygenase pathway suppresses including growth factors privacy choices/manage cookies receptor subtype ep3 regulates ppar-delta frizzled 9-dependent pathway endothelial cell function lung cancer cells colon cancer cells cell–cell interactions

Questions {❓}

A new avenue in anti-inflammatory therapy?
Nonsteroidal anti-inflammatory drugs and the heart: what is the danger?

Schema {🗺️}

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