We are analyzing https://link.springer.com/article/10.1007/s10555-010-9235-2.

Title:
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals | Cancer and Metastasis Reviews
Description:
Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary changes. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. The pathways associated with this process have been linked to chronic inflammation, a major mediator of tumor progression. The human body consists of about 13 trillion cells, almost all of which are turned over within 100 days, indicating that 70,000 cells undergo apoptosis every minute. Thus, apoptosis/cell death is a normal physiological process, and it is rare that a lack of apoptosis kills the patient. Almost 90% of all deaths due to cancer are linked to metastasis of the tumor. How our diet can prevent cancer is the focus of this review. Specifically, we will discuss how nutraceuticals, such as allicin, apigenin, berberine, butein, caffeic acid, capsaicin, catechin gallate, celastrol, curcumin, epigallocatechin gallate, fisetin, flavopiridol, gambogic acid, genistein, plumbagin, quercetin, resveratrol, sanguinarine, silibinin, sulforaphane, taxol, γ-tocotrienol, and zerumbone, derived from spices, legumes, fruits, nuts, and vegetables, can modulate inflammatory pathways and thus affect the survival, proliferation, invasion, angiogenesis, and metastasis of the tumor. Various cell signaling pathways that are modulated by these agents will also be discussed.
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Keywords {🔍}

google, scholar, cas, pubmed, article, cancer, cells, journal, human, cell, apoptosis, research, expression, inhibits, aggarwal, activation, molecular, inhibition, growth, invasion, tumor, kim, breast, angiogenesis, nuclear, pathway, gene, lee, signaling, nfkappab, prostate, proliferation, suppression, international, metastasis, acid, carcinoma, kinase, induces, matrix, wang, chen, liu, lung, factor, biological, chemistry, carcinogenesis, prevention, nutrition,

Topics {✒️}

12-o-tetradecanoylphorbol-13-acetate-induced nf-kappab activation wnt/egfr/nf-kappab-signaling pathways wnt/beta-catenin signaling pathway nf-kappab-regulated gene expression suppressing nf-kappab-regulated antiapoptotic tumour necrosis factor-alpha tnf-alpha-induced icam-1 expression c-jun n-terminal kinase inducible nuclear factor-kappa month download article/chapter nuclear factor-kappab pathway ultraviolet b-mediated activation nuclear factor-kappabalpha kinase targeting nuclear factor-kappa transforming growth factor-alpha inducible nf-kappab activation guggulsterone inhibits nf-kappab cas google scholar mitogen-activated protein kinases nf-kappab signaling pathway growth factor-stimulated proliferation transcription factor nf-kappa regulating nuclear factor-kappa nonpeptidic small-molecule antagonists inhibit tumour-specific angiogenesis e-cadherin/catenin complexes prostaglandin synthase/cyclooxygenase homologue anti-apoptotic gene products inhibiting nf-kappab activation c-rel transcription factor nik/ikk signalling complex protecting rb-e2f-1 complex nf-kappab/ap-1-dependent inhibiting cell–ecm adhesion enhances trail-induced apoptosis key cell-cycle regulators radiation-induced g1 arrest interleukin-6-inducible stat3 activation nuclear factor-kappab nuclear factor kappab zerumbone abolishes nf-kappab inhibits nuclear factor erk1-dependent signaling pathway hormone-refractory prostate cancer alpha/ikk signaling pathways prb-mediated growth suppression nuclear factor-kappa hot chili pepper reactive oxygen species increases e-cadherin production

Questions {❓}

Angiogenesis: An organizing principle for drug discovery?
Capsaicin in hot chili pepper: Carcinogen, co-carcinogen or anticarcinogen?
Inflammation and cancer: How friendly is the relationship for cancer patients?
Is there a benefit from lycopene supplementation in men with prostate cancer?
Nutraceuticals: Poised for a healthy slice of the healthcare market?

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