We are analyzing https://link.springer.com/article/10.1007/s10552-008-9281-z.

Title:
Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokers | Cancer Causes & Control
Description:
A history of type 2 diabetes is one of few consistent risk factors for pancreatic cancer. Potentially modifiable factors related to fasting insulin and glucose concentrations may influence pancreatic cancer risk. Multiple linear regression models were used to identify anthropometric, clinical, behavioral, and dietary factors associated with fasting insulin and glucose in a subcohort of non-diabetics in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 366). Hazards ratios (HRs) and 95% confidence intervals (CIs) were calculated among the larger cohort (n = 27,035). During follow-up (median 16.1 years), 305 participants developed pancreatic cancer. Fasting insulin and/or glucose were positively associated with body mass index (BMI), height, and dietary total and saturated fat and inversely associated with serum high-density lipoprotein cholesterol (HDL) and dietary available carbohydrates, sucrose, and alcohol. Comparing highest to lowest quintiles, total fat (HR = 1.54, 95% CI 1.05–2.25, p-trend = 0.01) and saturated fat (HR = 1.38, 95% CI 0.97–1.98, p-trend = 0.06) were positively associated and available carbohydrates (HR = 0.63, 95% CI 0.44–0.90, p-trend = 0.01), particularly sucrose (HR = 0.62, 95% CI 0.43–0.89, p-trend = 0.09), were inversely associated with risk of pancreatic cancer. BMI, HDL, height, and alcohol were not associated with pancreatic cancer risk. Dietary fat is associated with higher fasting insulin concentrations and may increase pancreatic cancer risk in smokers.
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Keywords {🔍}

cancer, google, scholar, pubmed, article, pancreatic, cas, risk, study, dietary, insulin, epidemiol, factors, diabetes, glucose, glycemic, fat, research, control, casecontrol, fasting, men, load, epidemiology, health, smokers, albanes, stolzenbergsolomon, cohort, clin, prospective, biomarkers, prev, serum, gonzalez, virtamo, prevention, pancreas, women, intake, privacy, cookies, content, meinhold, berrington, taylor, related, index, saturated, access,

Topics {✒️}

month download article/chapter berrington de gonzalez population-based case-control study methyl-group availability factors prediagnostic plasma c-peptide stolzenberg-solomon department chronic disease prevention insulin-dependent diabetes mellitus type-ii diabetes case-control study based energy-providing nutrients related large trial cohort—accuracy full article pdf de gonzalez genetic mouse model privacy choices/manage cookies population-based study abnormal glucose metabolism type 2 diabetes high-risk state national cancer institute johns hopkins school ansary-moghaddam intramural research program related subjects serum insulin concentrations fasting serum insulin epidemiological cancer research insulin resistance syndrome case-control study related metabolic disturbances modifiable risk factors european economic area normative aging study consistent risk factors oxford university press howe gr south-west poland asia-pacific region jee sh pancreatic cancer mortality pancreatic cancer incidence article cancer insulin metabolism high saturated fat finnish cancer registry multiethnic cohort study netherlands cohort study exocrine pancreatic tumors article log

Questions {❓}

Bueno de Mesquita HB, Moerman CJ, Runia S, Maisonneuve P (1990) Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas?
Cowey S, Hardy RW (2006) The metabolic syndrome: a high-risk state for cancer?

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         headline:Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokers
         description:A history of type 2 diabetes is one of few consistent risk factors for pancreatic cancer. Potentially modifiable factors related to fasting insulin and glucose concentrations may influence pancreatic cancer risk. Multiple linear regression models were used to identify anthropometric, clinical, behavioral, and dietary factors associated with fasting insulin and glucose in a subcohort of non-diabetics in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 366). Hazards ratios (HRs) and 95% confidence intervals (CIs) were calculated among the larger cohort (n = 27,035). During follow-up (median 16.1 years), 305 participants developed pancreatic cancer. Fasting insulin and/or glucose were positively associated with body mass index (BMI), height, and dietary total and saturated fat and inversely associated with serum high-density lipoprotein cholesterol (HDL) and dietary available carbohydrates, sucrose, and alcohol. Comparing highest to lowest quintiles, total fat (HR = 1.54, 95% CI 1.05–2.25, p-trend = 0.01) and saturated fat (HR = 1.38, 95% CI 0.97–1.98, p-trend = 0.06) were positively associated and available carbohydrates (HR = 0.63, 95% CI 0.44–0.90, p-trend = 0.01), particularly sucrose (HR = 0.62, 95% CI 0.43–0.89, p-trend = 0.09), were inversely associated with risk of pancreatic cancer. BMI, HDL, height, and alcohol were not associated with pancreatic cancer risk. Dietary fat is associated with higher fasting insulin concentrations and may increase pancreatic cancer risk in smokers.
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         Pancreatic cancer
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         Epidemiology
         Hematology
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