We are analyzing https://link.springer.com/article/10.1007/s10552-007-9003-y.

Title:
NSAIDs and breast cancer recurrence in a prospective cohort study | Cancer Causes & Control
Description:
Objective We examined the association between NSAID use and breast cancer recurrence in a prospective cohort of 2,292 early-stage breast cancer survivors diagnosed from 1997 to 2000 participating in the Life After Cancer Epidemiology (LACE) Study. Methods From 2000 to 2002, mailed questionnaires were used to obtain information on aspirin, ibuprofen, and other NSAID use and subsequent breast cancer events. A total of 270 recurrences (local, regional, and distant disease and new primary breast cancers) were reported and verified by medical record review. Cox proportional hazard models were used to estimate rate ratios (RR) and 95% confidence intervals (CI), adjusting for age at diagnosis, race, cancer stage, tamoxifen treatment, chemotherapy use, body mass index, and cyclooxygenase-2 (COX2) inhibitor use. Results Current, regular use (at least three days per week at time of questionnaire administration) of ibuprofen (RR, 0.56; 95% CI, 0.32–0.98), but not aspirin (RR, 1.09; 95% CI, 0.74–1.61), was associated with a statistically significant decreased risk of breast cancer recurrence. The combination of ibuprofen and other non-aspirin NSAIDs such as naproxen and sulindac reflected a similar reduction in risk (RR, 0.56; 95% CI, 0.33–0.95). No association was found for the non-NSAID analgesic acetaminophen. Conclusion Our findings provide support for an inverse association between current, regular ibuprofen use and breast cancer recurrence.
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month download article/chapter steroidal anti-inflammatory drugs keywords anti-inflammatory agents nonsteroidal anti-inflammatory drugs nonsteroidal anti-inflammatory drug spanish multi-case-control breast cancer chemoprevention related subjects full article pdf privacy choices/manage cookies nonsteroidal antiinflammatory drugs breast cancer recurrence prospective cohort study invasive breast cancer breast cancer incidence human breast cancer primary breast cancers breast cancer risk national cancer institute european economic area medical record review estimate rate ratios body mass index hormone receptor status garcia rodriguez la randomized controlled trial rat mammary adenocarcinomas rat mammary carcinomas reis-filho js lymph node metastasis salt lake city breast cancer diagnosis findings provide support cyclo-oxygenase 2 expression conditions privacy policy bmc cancer 3 comparative chemopreventive activity cyclooxygenase-2 gene expression article cancer accepting optional cookies lace study staff utah cancer registry anticancer drug development elevated cyclooxygenase-2 expression author information authors check access instant access article log low-dose aspirin ibuprofen-induced inhibition

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