We are analyzing https://link.springer.com/article/10.1007/s10552-004-1048-6.

Title:
Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States) | Cancer Causes & Control
Description:
Components of energy balance are important elements associated with colorectal cancer risk. In this study we examine the association between VDR genotypes, BMI, physical activity, and energy intake and risk of colorectal cancer. Data from a population-based case–control study of colon (1174 cases and 1174 controls) and rectal (785 cases and 1000 controls) cancer was used to evaluate the associations. The Bsm1, polyA, and Fok1 VDR polymorphisms were evaluated. For colon cancer, those who are obese were at greater risk of colon cancer if they had the SS or BB (OR=3.50; 95 CI=1.75–7.03; p interaction 0.03) or ff (OR=2.62; 95 CI=1.15–5.99; p interaction 0.12/) VDR genotypes. On the other hand, those who were least physically active were at greater risk of colon cancer if they had theff VDR genotype (OR=3.46; 95 CI=1.58–7.58; p interaction 0.05. The association between energy intake and colon cancer appears to be driven more by energy intake than Bsm1 or polyA VDR genotypes, although there was a significant interaction between the Fok1 VDR polymorphism and energy intake and risk of both colon and rectal cancer (p interaction 0.01 for colon and 0.04 for rectal). These data suggest a relationship between VDR genotype and factors related to energy balance in modifying colorectal cancer risk.
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Keywords {🔍}

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Topics {✒️}

population-based case–control study population-based case-control study leisure-time physical activity month download article/chapter colorectal-cancer risk int cardia dietary history colorectal cancer int health research center khe ni ma willett mj stampfer vdr protein levels large prospective study energy expenditure total energy intake american diabetes association physical activity privacy choices/manage cookies vitamin d-responsive elements dietary energy sources full article pdf colorectal cancer risk theff vdr genotype 29th research symposium genetic polymorphisms related subjects check access instant access igf binding proteins body mass index fatal colon cancer colon cancer appears colon cancer incidence igf-binding protein-3 fok1 vdr polymorphisms body size fok1 vdr polymorphism energy balance epithelial cell proliferation prostate cancer risk colon cancer risk article slattery european economic area inflammatory bowel disease confidence interval estimation hormone replacement therapy 7th international congress salt lake city energy intake colorectal cancer article cancer

Schema {🗺️}

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         headline:Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States)
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      headline:Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States)
      description:Components of energy balance are important elements associated with colorectal cancer risk. In this study we examine the association between VDR genotypes, BMI, physical activity, and energy intake and risk of colorectal cancer. Data from a population-based case–control study of colon (1174 cases and 1174 controls) and rectal (785 cases and 1000 controls) cancer was used to evaluate the associations. The Bsm1, polyA, and Fok1 VDR polymorphisms were evaluated. For colon cancer, those who are obese were at greater risk of colon cancer if they had the SS or BB (OR=3.50; 95 CI=1.75–7.03; p interaction 0.03) or ff (OR=2.62; 95 CI=1.15–5.99; p interaction 0.12/) VDR genotypes. On the other hand, those who were least physically active were at greater risk of colon cancer if they had theff VDR genotype (OR=3.46; 95 CI=1.58–7.58; p interaction 0.05. The association between energy intake and colon cancer appears to be driven more by energy intake than Bsm1 or polyA VDR genotypes, although there was a significant interaction between the Fok1 VDR polymorphism and energy intake and risk of both colon and rectal cancer (p interaction 0.01 for colon and 0.04 for rectal). These data suggest a relationship between VDR genotype and factors related to energy balance in modifying colorectal cancer risk.
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      dateModified:
      pageStart:863
      pageEnd:872
      sameAs:https://doi.org/10.1007/s10552-004-1048-6
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         body size
         colorectal cancer
         energy balance
         energy expenditure
         energy intake
         physical activity
          VDR
         Cancer Research
         Biomedicine
         general
         Oncology
         Public Health
         Epidemiology
         Hematology
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