We are analyzing https://link.springer.com/article/10.1007/s10549-016-4059-6.

Title:
Triple-negative breast cancer has worse overall survival and cause-specific survival than non-triple-negative breast cancer | Breast Cancer Research and Treatment
Description:
Purpose The current American Joint Committee on Cancer (AJCC) staging manual uses tumor size, lymph node, and metastatic status to stage breast cancer across different subtypes. We examined the prognosis of triple-negative breast cancer (TNBC) versus non-TNBC within the same stages and sub-stages to evaluate whether TNBC had worse prognosis than non-TNBC. Methods We reviewed the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) data and identified 158,358 patients diagnosed with breast cancer from 2010 to 2012. The overall survival (OS) time and breast cancer cause-specific survival time were compared between patients with TNBC and non-TNBC in each stage and sub-stages. The results were validated using a dataset of 2049 patients with longer follow-up from our institution. Results Compared with patients with non-TNBC, patients with TNBC had worse OS and breast cancer cause-specific survival time in every stage and sub-stage in univariate and multivariate analyses adjusting for age, race, tumor grade, and surgery and radiation treatments in the SEER data. The worse OS time in patients with TNBC was validated in our institutional dataset. Conclusions Patients with TNBC have worse survival than patients with non-TNBC. The new AJCC staging manual should consider breast cancer biomarker information.
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Keywords {🔍}

cancer, breast, article, pubmed, google, scholar, survival, triplenegative, cas, patients, central, clin, tnbc, staging, usa, data, worse, oncol, content, stage, nontnbc, center, authors, department, university, privacy, cookies, research, causespecific, joint, institute, time, cancers, chemotherapy, analysis, information, publish, search, november, yang, peng, sahin, american, committee, ajcc, prognosis, compared, access, res, springer,

Topics {✒️}

month download article/chapter brca1-positive breast cancers triple-negative breast cancers disease-free survival predicting disease-specific survival triple-negative breast cancer triple-negative breast cancer stromal pd-l1 expression patient-level meta-analysis residual breast cancers subtype breast cancers full article pdf cancer staging system privacy choices/manage cookies breast cancer treated ajcc staging manual stage breast cancer mittendorf ea winship cancer institute american joint committee differentiate breast carcinoma edge sb molecular heterogeneity article li electronic supplementary material li xb androgen receptor planned joint analysis european economic area multivariate analyses adjusting related subjects geyer ce jr specific survival time conditions privacy policy reis-filho js breast cancer article log accepting optional cookies gonzalez-angulo ethics declarations conflict worse prognosis author information authors staging manual xiaoxian li stage ib designation article cite tumor-initiating features journal finder publish staging system specific survival

Questions {❓}

Outcomes of Triple-Negative Breast Cancers (TNBC) Compared with Non-TNBC: Does the Survival Vary for All Stages?

Schema {🗺️}

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         description:The current American Joint Committee on Cancer (AJCC) staging manual uses tumor size, lymph node, and metastatic status to stage breast cancer across different subtypes. We examined the prognosis of triple-negative breast cancer (TNBC) versus non-TNBC within the same stages and sub-stages to evaluate whether TNBC had worse prognosis than non-TNBC. We reviewed the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) data and identified 158,358 patients diagnosed with breast cancer from 2010 to 2012. The overall survival (OS) time and breast cancer cause-specific survival time were compared between patients with TNBC and non-TNBC in each stage and sub-stages. The results were validated using a dataset of 2049 patients with longer follow-up from our institution. Compared with patients with non-TNBC, patients with TNBC had worse OS and breast cancer cause-specific survival time in every stage and sub-stage in univariate and multivariate analyses adjusting for age, race, tumor grade, and surgery and radiation treatments in the SEER data. The worse OS time in patients with TNBC was validated in our institutional dataset. Patients with TNBC have worse survival than patients with non-TNBC. The new AJCC staging manual should consider breast cancer biomarker information.
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            Cancer staging
            Oncology
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         TNBC
         Prognosis
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         Oncology
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