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Title:
The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial | Breast Cancer Research and Treatment
Description:
The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors.
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Keywords {🔍}
pubmed, google, scholar, article, cancer, cas, breast, exercise, training, natural, killer, cells, survivors, cell, patients, resistance, function, trial, immunol, med, controlled, central, immune, women, randomized, oncol, clin, university, res, sci, effect, blood, activity, muscle, sports, research, expression, peripheral, necrosis, human, factor, sydney, australia, effects, nkt, serum, strength, tumor, therapy, bone,
Topics {✒️}
month download article/chapter high-sensitivity c-reactive protein lymphokine-activated killer cells cachectin/tumor necrosis factor tumor necrosis factor-alpha tumour necrosis factor-alpha natural killer t-cell long-term resistance training short-term resistance training natural-killer-cell function full article pdf tumor necrosis factor breast-cancer-related lymphedema whiteside tl c-reactive protein tumour necrosis factor natural killer cells natural killer cell natural killer activity american cancer society adjuvant hormone therapy fiatarone singh ma chronic lymphocytic leukemia winters-stone privacy choices/manage cookies human breast cancer advanced breast cancer breast cancer survivors breast cancer cells nkt cell function alter body composition natural killer cytotoxicity performance research group randomized controlled trial epithelial cancer cells nk-cell function /b-expressing cells randomised controlled trial breast cancer incidence breast cancer prevention nkt cell expression flexibility/resistance exercise lower tnf-alpha spss survival manual peripheral lymphocyte population age-related diseases peripheral blood lymphocytes invasive breast carcinoma nk cell expression progressive strength training
Questions {❓}
- Natural Killer Cells: What Have We Learned?
- Pedersen B, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, Febbraio M, Saltin B (2003) Searching for the exercise factor: is IL-6 a candidate?
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headline:The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial
description:The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors.
datePublished:2016-01-28T00:00:00Z
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Resistance training
Immune function
Inflammation
Breast cancer survivors
Oncology
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headline:The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: a randomized controlled trial
description:The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors.
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Immune function
Inflammation
Breast cancer survivors
Oncology
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