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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s10549-012-2315-y.

Title:
Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up | Breast Cancer Research and Treatment
Description:
Studies on well characterized, large populations of estrogen receptor (ER)/progesterone receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long-term follow-up are lacking. In this study, we analyze clinical outcomes of TN BC and implications of epidermal growth factor receptor (EGFR) expression. Clinical and biologic features, time to first recurrence (TTFR), and overall survival (OS) were compared in 253 TN versus 1,036 ER positive, PgR positive, HER2-negative [estrogen-driven (ED)] BC. Compared to ED, TN tumors were larger (p = 0.02), more proliferative (high S-phase 54 vs. 17 %, p < 0.0001), more aneuploid (64 vs. 43 %, p < 0.0001) and more likely EGFR positive (≄10 fmol/mg by radioligand-binding assay, 49 vs. 7 %, p < 0.0001). Among TN, EGFR-positive BC were larger (p = 0.0018), more proliferative (p < 0.0001), and more aneuploid, (p < 0.0001) than EGFR-negative BC. Adjuvant-treated TN patients had shorter TTFR (p = 0.0003), and OS (p = 0.0017), than ED patients. However, in untreated patients, no differences in TTFR and OS were observed at 8 years median follow-up. Among TN patients, EGFR expression was not associated with worse outcome. TN tumors have a worse outcome in systemically treated patients but not in untreated patients. EGFR expression, does not predict for worse long-term survival.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Health & Fitness
  • Science

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

check SE Ranking
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How Does Link.springer.com Make Money? {šŸ’ø}

The income method remains a mystery to us.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {šŸ”}

cancer, breast, article, google, scholar, pubmed, cas, receptor, res, triplenegative, patients, expression, clinical, egfr, clin, prognostic, prognosis, treat, growth, factor, natl, basallike, oncol, cancers, estrogen, access, usa, breastcancer, privacy, cookies, content, research, biologic, features, shetty, rimawi, implications, epidermal, gene, phenotype, metastatic, owens, data, publish, search, longterm, followup, malorni, angelis, hilsenbeck,

Topics {āœ’ļø}

node-negative breast-cancer patients month download article/chapter invasive ductal carcinoma her2-negative [estrogen-driven /her2-negative [triple-negative triple-negative breast cancers node-negative breast-cancer triple-negative breast cancer perou cm nih grant p50-ca58183 clinic-based african american estrogen receptor-positive estrogen receptor assays full article pdf related subjects triple-negative tumours triple-negative subtype metastatic triple negative primary breast cancer worse long-term survival privacy choices/manage cookies triple-negative phenotype ļæ½triple-negativeā€ phenotype breast cancer classification breast cancer synonymous breast cancer defined adjuvant-treated tn patients breast tumor subtypes metastatic breast cancer 000 breast-cancer patients human breast tumours duncan cancer center estrogen receptor triple-negative/basal breast cancer association /progesterone receptor progesterone receptor long-term follow institutional-based review egfr-negative bc 1103 breast cancers van der vegt systemically treated patients gene expression profiles gene expression profiling european economic area scope submit manuscript radioligand-binding assay 8Ā years median follow flow-cytometry identifies

Questions {ā“}

  • Bertucci F, Finetti P, Cervera N et al (2008) How basal are triple-negative breast cancers?
  • Kreike B, van de Vijver MJ (2007) Are triple-negative tumours and basal-like breast cancer synonymous?

Schema {šŸ—ŗļø}

WebPage:
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         headline:Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up
         description:Studies on well characterized, large populations of estrogen receptor (ER)/progesterone receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long-term follow-up are lacking. In this study, we analyze clinical outcomes of TN BC and implications of epidermal growth factor receptor (EGFR) expression. Clinical and biologic features, time to first recurrence (TTFR), and overall survival (OS) were compared in 253 TN versus 1,036 ER positive, PgR positive, HER2-negative [estrogen-driven (ED)] BC. Compared to ED, TN tumors were larger (pĀ =Ā 0.02), more proliferative (high S-phase 54 vs. 17Ā %, pĀ <Ā 0.0001), more aneuploid (64 vs. 43Ā %, pĀ <Ā 0.0001) and more likely EGFR positive (≄10Ā fmol/mg by radioligand-binding assay, 49 vs. 7Ā %, pĀ <Ā 0.0001). Among TN, EGFR-positive BC were larger (pĀ =Ā 0.0018), more proliferative (pĀ <Ā 0.0001), and more aneuploid, (pĀ <Ā 0.0001) than EGFR-negative BC. Adjuvant-treated TN patients had shorter TTFR (pĀ =Ā 0.0003), and OS (pĀ =Ā 0.0017), than ED patients. However, in untreated patients, no differences in TTFR and OS were observed at 8Ā years median follow-up. Among TN patients, EGFR expression was not associated with worse outcome. TN tumors have a worse outcome in systemically treated patients but not in untreated patients. EGFR expression, does not predict for worse long-term survival.
         datePublished:2012-11-04T00:00:00Z
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            Triple-negative breast cancer
            Oncology
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      headline:Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up
      description:Studies on well characterized, large populations of estrogen receptor (ER)/progesterone receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long-term follow-up are lacking. In this study, we analyze clinical outcomes of TN BC and implications of epidermal growth factor receptor (EGFR) expression. Clinical and biologic features, time to first recurrence (TTFR), and overall survival (OS) were compared in 253 TN versus 1,036 ER positive, PgR positive, HER2-negative [estrogen-driven (ED)] BC. Compared to ED, TN tumors were larger (pĀ =Ā 0.02), more proliferative (high S-phase 54 vs. 17Ā %, pĀ <Ā 0.0001), more aneuploid (64 vs. 43Ā %, pĀ <Ā 0.0001) and more likely EGFR positive (≄10Ā fmol/mg by radioligand-binding assay, 49 vs. 7Ā %, pĀ <Ā 0.0001). Among TN, EGFR-positive BC were larger (pĀ =Ā 0.0018), more proliferative (pĀ <Ā 0.0001), and more aneuploid, (pĀ <Ā 0.0001) than EGFR-negative BC. Adjuvant-treated TN patients had shorter TTFR (pĀ =Ā 0.0003), and OS (pĀ =Ā 0.0017), than ED patients. However, in untreated patients, no differences in TTFR and OS were observed at 8Ā years median follow-up. Among TN patients, EGFR expression was not associated with worse outcome. TN tumors have a worse outcome in systemically treated patients but not in untreated patients. EGFR expression, does not predict for worse long-term survival.
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         Basal-like breast cancer
         EGFR
         Estrogen receptor
         HER2
         Progesterone receptor
         Triple-negative breast cancer
         Oncology
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                     type:PostalAddress
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                  name:Hospital of Prato
                  address:
                     name:ā€œSandro Pitiglianiā€ Oncology Unit, Hospital of Prato, Prato, Italy
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                  address:
                     name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
                     type:PostalAddress
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                  name:Dun L. Duncan Cancer Center at Baylor College of Medicine
                  address:
                     name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:C. De Angelis
            affiliation:
                  name:University of Naples Federico II
                  address:
                     name:Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
                     type:PostalAddress
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            email:[email protected]
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            name:S. Hilsenbeck
            affiliation:
                  name:Lester and Sue Smith Breast Center at Baylor College of Medicine
                  address:
                     name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:Dun L. Duncan Cancer Center at Baylor College of Medicine
                  address:
                     name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
                     type:PostalAddress
                  type:Organization
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            name:M. F. Rimawi
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                  name:Lester and Sue Smith Breast Center at Baylor College of Medicine
                  address:
                     name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
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                  name:Dun L. Duncan Cancer Center at Baylor College of Medicine
                  address:
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                  name:Lester and Sue Smith Breast Center at Baylor College of Medicine
                  address:
                     name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
                     type:PostalAddress
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                  name:Dun L. Duncan Cancer Center at Baylor College of Medicine
                  address:
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                     type:PostalAddress
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                  name:Dun L. Duncan Cancer Center at Baylor College of Medicine
                  address:
                     name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. De Placido
            affiliation:
                  name:University of Naples Federico II
                  address:
                     name:Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
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            name:G. Arpino
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         name:ā€œSandro Pitiglianiā€ Oncology Unit, Hospital of Prato, Prato, Italy
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            name:Lester and Sue Smith Breast Center at Baylor College of Medicine
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               name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
               type:PostalAddress
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      name:M. F. Rimawi
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               name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
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            name:Dun L. Duncan Cancer Center at Baylor College of Medicine
            address:
               name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
               type:PostalAddress
            type:Organization
      name:R. Elledge
      affiliation:
            name:Lester and Sue Smith Breast Center at Baylor College of Medicine
            address:
               name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
               type:PostalAddress
            type:Organization
            name:Dun L. Duncan Cancer Center at Baylor College of Medicine
            address:
               name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
               type:PostalAddress
            type:Organization
      name:C. K. Osborne
      affiliation:
            name:Lester and Sue Smith Breast Center at Baylor College of Medicine
            address:
               name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
               type:PostalAddress
            type:Organization
            name:Dun L. Duncan Cancer Center at Baylor College of Medicine
            address:
               name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
               type:PostalAddress
            type:Organization
      name:S. De Placido
      affiliation:
            name:University of Naples Federico II
            address:
               name:Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
               type:PostalAddress
            type:Organization
      name:G. Arpino
      affiliation:
            name:University of Naples Federico II
            address:
               name:Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
      name:ā€œSandro Pitiglianiā€ Oncology Unit, Hospital of Prato, Prato, Italy
      name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
      name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
      name:Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
      name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
      name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
      name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
      name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
      name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
      name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
      name:Lester and Sue Smith Breast Center at Baylor College of Medicine, Houston, USA
      name:Dun L. Duncan Cancer Center at Baylor College of Medicine, Houston, USA
      name:Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
      name:Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
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