
LINK . SPRINGER . COM {
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Title:
Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up | Breast Cancer Research and Treatment
Description:
Studies on well characterized, large populations of estrogen receptor (ER)/progesterone receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long-term follow-up are lacking. In this study, we analyze clinical outcomes of TN BC and implications of epidermal growth factor receptor (EGFR) expression. Clinical and biologic features, time to first recurrence (TTFR), and overall survival (OS) were compared in 253 TN versus 1,036 ER positive, PgR positive, HER2-negative [estrogen-driven (ED)] BC. Compared to ED, TN tumors were larger (p = 0.02), more proliferative (high S-phase 54 vs. 17 %, p < 0.0001), more aneuploid (64 vs. 43 %, p < 0.0001) and more likely EGFR positive (ā„10 fmol/mg by radioligand-binding assay, 49 vs. 7 %, p < 0.0001). Among TN, EGFR-positive BC were larger (p = 0.0018), more proliferative (p < 0.0001), and more aneuploid, (p < 0.0001) than EGFR-negative BC. Adjuvant-treated TN patients had shorter TTFR (p = 0.0003), and OS (p = 0.0017), than ED patients. However, in untreated patients, no differences in TTFR and OS were observed at 8 years median follow-up. Among TN patients, EGFR expression was not associated with worse outcome. TN tumors have a worse outcome in systemically treated patients but not in untreated patients. EGFR expression, does not predict for worse long-term survival.
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Keywords {š}
cancer, breast, article, google, scholar, pubmed, cas, receptor, res, triplenegative, patients, expression, clinical, egfr, clin, prognostic, prognosis, treat, growth, factor, natl, basallike, oncol, cancers, estrogen, access, usa, breastcancer, privacy, cookies, content, research, biologic, features, shetty, rimawi, implications, epidermal, gene, phenotype, metastatic, owens, data, publish, search, longterm, followup, malorni, angelis, hilsenbeck,
Topics {āļø}
node-negative breast-cancer patients month download article/chapter invasive ductal carcinoma her2-negative [estrogen-driven /her2-negative [triple-negative triple-negative breast cancers node-negative breast-cancer triple-negative breast cancer perou cm nih grant p50-ca58183 clinic-based african american estrogen receptor-positive estrogen receptor assays full article pdf related subjects triple-negative tumours triple-negative subtype metastatic triple negative primary breast cancer worse long-term survival privacy choices/manage cookies triple-negative phenotype ļæ½triple-negativeā phenotype breast cancer classification breast cancer synonymous breast cancer defined adjuvant-treated tn patients breast tumor subtypes metastatic breast cancer 000 breast-cancer patients human breast tumours duncan cancer center estrogen receptor triple-negative/basal breast cancer association /progesterone receptor progesterone receptor long-term follow institutional-based review egfr-negative bc 1103 breast cancers van der vegt systemically treated patients gene expression profiles gene expression profiling european economic area scope submit manuscript radioligand-binding assay 8Ā years median follow flow-cytometry identifies
Questions {ā}
- Bertucci F, Finetti P, Cervera N et al (2008) How basal are triple-negative breast cancers?
- Kreike B, van de Vijver MJ (2007) Are triple-negative tumours and basal-like breast cancer synonymous?
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headline:Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up
description:Studies on well characterized, large populations of estrogen receptor (ER)/progesterone receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long-term follow-up are lacking. In this study, we analyze clinical outcomes of TN BC and implications of epidermal growth factor receptor (EGFR) expression. Clinical and biologic features, time to first recurrence (TTFR), and overall survival (OS) were compared in 253 TN versus 1,036 ER positive, PgR positive, HER2-negative [estrogen-driven (ED)] BC. Compared to ED, TN tumors were larger (pĀ =Ā 0.02), more proliferative (high S-phase 54 vs. 17Ā %, pĀ <Ā 0.0001), more aneuploid (64 vs. 43Ā %, pĀ <Ā 0.0001) and more likely EGFR positive (ā„10Ā fmol/mg by radioligand-binding assay, 49 vs. 7Ā %, pĀ <Ā 0.0001). Among TN, EGFR-positive BC were larger (pĀ =Ā 0.0018), more proliferative (pĀ <Ā 0.0001), and more aneuploid, (pĀ <Ā 0.0001) than EGFR-negative BC. Adjuvant-treated TN patients had shorter TTFR (pĀ =Ā 0.0003), and OS (pĀ =Ā 0.0017), than ED patients. However, in untreated patients, no differences in TTFR and OS were observed at 8Ā years median follow-up. Among TN patients, EGFR expression was not associated with worse outcome. TN tumors have a worse outcome in systemically treated patients but not in untreated patients. EGFR expression, does not predict for worse long-term survival.
datePublished:2012-11-04T00:00:00Z
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Basal-like breast cancer
EGFR
Estrogen receptor
HER2
Progesterone receptor
Triple-negative breast cancer
Oncology
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headline:Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up
description:Studies on well characterized, large populations of estrogen receptor (ER)/progesterone receptor (PgR)/HER2-negative [triple-negative (TN)] breast cancer (BC) patients with long-term follow-up are lacking. In this study, we analyze clinical outcomes of TN BC and implications of epidermal growth factor receptor (EGFR) expression. Clinical and biologic features, time to first recurrence (TTFR), and overall survival (OS) were compared in 253 TN versus 1,036 ER positive, PgR positive, HER2-negative [estrogen-driven (ED)] BC. Compared to ED, TN tumors were larger (pĀ =Ā 0.02), more proliferative (high S-phase 54 vs. 17Ā %, pĀ <Ā 0.0001), more aneuploid (64 vs. 43Ā %, pĀ <Ā 0.0001) and more likely EGFR positive (ā„10Ā fmol/mg by radioligand-binding assay, 49 vs. 7Ā %, pĀ <Ā 0.0001). Among TN, EGFR-positive BC were larger (pĀ =Ā 0.0018), more proliferative (pĀ <Ā 0.0001), and more aneuploid, (pĀ <Ā 0.0001) than EGFR-negative BC. Adjuvant-treated TN patients had shorter TTFR (pĀ =Ā 0.0003), and OS (pĀ =Ā 0.0017), than ED patients. However, in untreated patients, no differences in TTFR and OS were observed at 8Ā years median follow-up. Among TN patients, EGFR expression was not associated with worse outcome. TN tumors have a worse outcome in systemically treated patients but not in untreated patients. EGFR expression, does not predict for worse long-term survival.
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Basal-like breast cancer
EGFR
Estrogen receptor
HER2
Progesterone receptor
Triple-negative breast cancer
Oncology
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