We are analyzing https://link.springer.com/article/10.1007/s10549-010-1116-4.

Title:
Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis | Breast Cancer Research and Treatment
Description:
Adult weight gain is positively associated with postmenopausal breast cancer and inversely associated with premenopausal breast cancer risk. To date, no meta-analysis has been conducted to assess this association by estrogen receptor (ER) and progesterone receptor (PR) status. We searched PubMed for relevant studies published through March 2010. Summarized risk estimates (REs) with 95% confidence intervals (CIs) were calculated using random effects or fixed effects models. We retrieved nine articles on weight gain from adulthood to reference age and ER- and/or PR-defined breast cancer risk, reporting on three prospective cohort studies and eight case–control studies. Comparing the highest versus the lowest categories of adult weight gain, risk was increased for ER+PR+ and ER+ tumors combined (11 studies; RE = 2.03; 95% CI 1.62, 2.45). Statistically significant heterogeneity (p heterogeneity = 0.002) was shown between REs for a mixed population of pre- and postmenopausal women combined (4 studies; RE = 1.54; 95% CI 0.86, 2.22) and for postmenopausal women only (7 studies; RE = 2.33; 95% CI 2.05, 2.60). Risk for ER−PR− tumors among postmenopausal women was also slightly increased (7 studies; RE = 1.34; 95% CI 1.06, 1.63), but statistically significantly different from risk for ER+PR+ tumors (p heterogeneity < 0.0001). No associations were observed for ER+PR− tumors whereas risk for ER−PR+ tumors could not be assessed. In conclusion, the association between adult weight gain and postmenopausal breast cancer risk is heterogeneous according to ER/PR status and stronger for ER+PR+ than for ER−PR− tumors.
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Keywords {🔍}

cancer, breast, article, google, scholar, pubmed, risk, weight, cas, postmenopausal, gain, body, receptor, metaanalysis, adult, status, women, epidemiol, research, estrogen, studies, erpr, change, progesterone, tumors, hormone, size, privacy, cookies, content, relation, res, access, study, mass, biomarkers, prev, publish, search, vrieling, kaaks, association, heterogeneity, factors, willett, doiepi, press, york, data, information,

Topics {✒️}

rudolf kaaks & jenny chang-claude month download article/chapter hormone receptor-positive early-stage breast cancer hormone replacement therapy meta-analysis review published progesterone receptor status progesterone receptor status breast cancer defined full article pdf breast cancer study privacy choices/manage cookies breast cancer risk adult weight gain postmenopausal breast cancer body mass index cancer research risk factors progesterone receptor lacey jv jr meta-analysis detected adult weight change large prospective study endogenous estrogen concentrations european economic area summarized risk estimates ballard-barbash ramirez-marrero fa 1007/s10549-006-9292 development core team general parametric approach check access instant access article vrieling conditions privacy policy relevant studies published harvard university press oxford university press er+ tumors combined reviewing research estrogen receptor fixed effects models searched pubmed breast cancer er−pr− tumors er+pr+ tumors er+pr− tumors er−pr+ tumors er/pr status randomized clinical trials

Questions {❓}

Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J (2006) Assessing heterogeneity in meta-analysis: Q statistic or I 2 index?
Weight gain in hormone receptor-positive (HR+) early-stage breast cancer: is it menopausal status or something else?

Schema {🗺️}

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         headline:Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis
         description:Adult weight gain is positively associated with postmenopausal breast cancer and inversely associated with premenopausal breast cancer risk. To date, no meta-analysis has been conducted to assess this association by estrogen receptor (ER) and progesterone receptor (PR) status. We searched PubMed for relevant studies published through March 2010. Summarized risk estimates (REs) with 95% confidence intervals (CIs) were calculated using random effects or fixed effects models. We retrieved nine articles on weight gain from adulthood to reference age and ER- and/or PR-defined breast cancer risk, reporting on three prospective cohort studies and eight case–control studies. Comparing the highest versus the lowest categories of adult weight gain, risk was increased for ER+PR+ and ER+ tumors combined (11 studies; RE = 2.03; 95% CI 1.62, 2.45). Statistically significant heterogeneity (p heterogeneity = 0.002) was shown between REs for a mixed population of pre- and postmenopausal women combined (4 studies; RE = 1.54; 95% CI 0.86, 2.22) and for postmenopausal women only (7 studies; RE = 2.33; 95% CI 2.05, 2.60). Risk for ER−PR− tumors among postmenopausal women was also slightly increased (7 studies; RE = 1.34; 95% CI 1.06, 1.63), but statistically significantly different from risk for ER+PR+ tumors (p heterogeneity < 0.0001). No associations were observed for ER+PR− tumors whereas risk for ER−PR+ tumors could not be assessed. In conclusion, the association between adult weight gain and postmenopausal breast cancer risk is heterogeneous according to ER/PR status and stronger for ER+PR+ than for ER−PR− tumors.
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      description:Adult weight gain is positively associated with postmenopausal breast cancer and inversely associated with premenopausal breast cancer risk. To date, no meta-analysis has been conducted to assess this association by estrogen receptor (ER) and progesterone receptor (PR) status. We searched PubMed for relevant studies published through March 2010. Summarized risk estimates (REs) with 95% confidence intervals (CIs) were calculated using random effects or fixed effects models. We retrieved nine articles on weight gain from adulthood to reference age and ER- and/or PR-defined breast cancer risk, reporting on three prospective cohort studies and eight case–control studies. Comparing the highest versus the lowest categories of adult weight gain, risk was increased for ER+PR+ and ER+ tumors combined (11 studies; RE = 2.03; 95% CI 1.62, 2.45). Statistically significant heterogeneity (p heterogeneity = 0.002) was shown between REs for a mixed population of pre- and postmenopausal women combined (4 studies; RE = 1.54; 95% CI 0.86, 2.22) and for postmenopausal women only (7 studies; RE = 2.33; 95% CI 2.05, 2.60). Risk for ER−PR− tumors among postmenopausal women was also slightly increased (7 studies; RE = 1.34; 95% CI 1.06, 1.63), but statistically significantly different from risk for ER+PR+ tumors (p heterogeneity < 0.0001). No associations were observed for ER+PR− tumors whereas risk for ER−PR+ tumors could not be assessed. In conclusion, the association between adult weight gain and postmenopausal breast cancer risk is heterogeneous according to ER/PR status and stronger for ER+PR+ than for ER−PR− tumors.
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         Breast cancer
         Estrogen receptor
         Progesterone receptor
         Meta-analysis
         Oncology
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