We are analyzing https://link.springer.com/article/10.1007/s10549-008-0262-4.

Title:
Fok1 polymorphism of vitamin D receptor gene contributes to breast cancer susceptibility: a meta-analysis | Breast Cancer Research and Treatment
Description:
Several polymorphisms in the vitamin D receptor (VDR) gene have been reported to influence breast cancer risk. However, the published findings have been conflicting. We conducted a meta-analysis of 21 case–control studies with Fok1 (eight studies with 5,284 cases and 7,500 controls), Bsm1 (14 studies with 5,498 cases and 7,943 controls), Apa1 (four studies with 1,138 cases and 7,943 controls), Taq1 (10 studies with 4,459 cases and 5,485 controls) polymorphisms. The results showed Fok1 polymorphism was associated with an overall significantly increased risk of breast cancer (ff vs. FF: OR = 1.15, 95% CI = 1.03–1.28; the recessive model ff vs. Ff + FF: OR = 1.14, 95% CI = 1.03–1.26). In subgroup analysis, a significant association was evident between Fok1 polymorphism and breast cancer in European population (ff vs. FF: OR = 1.16, 95% CI = 1.04–1.30; the recessive model ff vs. Ff + FF: OR = 1.15, 95% CI = 1.04–1.28). There was no between-study heterogeneity in any of these analyses. No significant associations were observed between the Bsm1, Apa1 and Taq1 variants and breast cancer risk. So, the current meta-analysis shows that Fok1 may be a susceptibility biomarker for breast cancer especially in European population.
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Keywords {🔍}

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Topics {✒️}

hua yuan & yifei du month download article/chapter current meta-analysis shows nested case-control study early-onset breast cancer bertone-johnson er meta-analysis epidemiology published estrogen-metabolizing gene polymorphisms full article pdf related subjects privacy choices/manage cookies genomics genetic predisposition meta-analysis detected postmenopausal breast cancer sporadic breast cancer brca1/2-mutation carrier breast cancer risk breast cancer prognosis breast cancer progression metastatic breast cancer breast cancer susceptibility african-american women breast carcinoma risk bovine parathyroid cells malignant breast tissue article tang receptor gene polymorphism significantly increased risk 21 case–control studies case-control studies ingles sa van meurs jb multiple promoters direct tissue-specific expression french canadian population translation initiation codon proto-oncogene expression van leeuwen jp conditions privacy policy receptor gene contributes receptor gene predispose receptor gene transcripts van duijn cm pathway gene polymorphisms check access instant access article log european economic area uk caucasian population receptor gene polymorphisms

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         headline:Fok1 polymorphism of vitamin D receptor gene contributes to breast cancer susceptibility: a meta-analysis
         description:Several polymorphisms in the vitamin D receptor (VDR) gene have been reported to influence breast cancer risk. However, the published findings have been conflicting. We conducted a meta-analysis of 21 case–control studies with Fok1 (eight studies with 5,284 cases and 7,500 controls), Bsm1 (14 studies with 5,498 cases and 7,943 controls), Apa1 (four studies with 1,138 cases and 7,943 controls), Taq1 (10 studies with 4,459 cases and 5,485 controls) polymorphisms. The results showed Fok1 polymorphism was associated with an overall significantly increased risk of breast cancer (ff vs. FF: OR = 1.15, 95% CI = 1.03–1.28; the recessive model ff vs. Ff + FF: OR = 1.14, 95% CI = 1.03–1.26). In subgroup analysis, a significant association was evident between Fok1 polymorphism and breast cancer in European population (ff vs. FF: OR = 1.16, 95% CI = 1.04–1.30; the recessive model ff vs. Ff + FF: OR = 1.15, 95% CI = 1.04–1.28). There was no between-study heterogeneity in any of these analyses. No significant associations were observed between the Bsm1, Apa1 and Taq1 variants and breast cancer risk. So, the current meta-analysis shows that Fok1 may be a susceptibility biomarker for breast cancer especially in European population.
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      description:Several polymorphisms in the vitamin D receptor (VDR) gene have been reported to influence breast cancer risk. However, the published findings have been conflicting. We conducted a meta-analysis of 21 case–control studies with Fok1 (eight studies with 5,284 cases and 7,500 controls), Bsm1 (14 studies with 5,498 cases and 7,943 controls), Apa1 (four studies with 1,138 cases and 7,943 controls), Taq1 (10 studies with 4,459 cases and 5,485 controls) polymorphisms. The results showed Fok1 polymorphism was associated with an overall significantly increased risk of breast cancer (ff vs. FF: OR = 1.15, 95% CI = 1.03–1.28; the recessive model ff vs. Ff + FF: OR = 1.14, 95% CI = 1.03–1.26). In subgroup analysis, a significant association was evident between Fok1 polymorphism and breast cancer in European population (ff vs. FF: OR = 1.16, 95% CI = 1.04–1.30; the recessive model ff vs. Ff + FF: OR = 1.15, 95% CI = 1.04–1.28). There was no between-study heterogeneity in any of these analyses. No significant associations were observed between the Bsm1, Apa1 and Taq1 variants and breast cancer risk. So, the current meta-analysis shows that Fok1 may be a susceptibility biomarker for breast cancer especially in European population.
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