We are analyzing https://link.springer.com/article/10.1007/s10549-007-9888-x.

Title:
A spontaneous estrogen dependent, tamoxifen sensitive mouse mammary tumor: a new model system to study hormone-responsiveness in immune competent mice | Breast Cancer Research and Treatment
Description:
Currently, an in vivo spontaneous model of estrogen dependent, tamoxifen sensitive breast cancer does not exist. We show here the characterization of the M05 mammary tumor that appeared spontaneously in a 1-year-old virgin female BALB/c mouse in our animal facility. The M05 tumor is a semi-differentiated adenocarcinoma that expresses estrogen and progesterone receptors. When it was transplanted to either male or ovariectomized female mice it did not grow. Moreover, ovariectomy or treatment with tamoxifen of tumor bearing mice led to a halt in tumor growth. Treatment of ovariectomized mice that had been inoculated with the M05 tumor showed that only estradiol, but not progesterone, promoted the re-growth of the tumor. Finally, after passage nine, tumor growth was achieved in male and ovariectomized female mice suggesting that the tumor had progressed to hormone independence. However, like often found in the clinic, expression of estrogen and progesterone receptors was maintained. This model mimics the biology of estrogen receptor positive breast cancer in humans and presents itself as an invaluable tool for the study of endocrine resistance in a physiologically relevant setting.
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Keywords {🔍}

cancer, article, breast, google, scholar, pubmed, tumor, cas, mammary, estrogen, tamoxifen, mice, res, treatment, model, expression, access, research, mouse, receptors, privacy, cookies, content, study, simian, characterization, human, publish, search, dependent, sensitive, immune, marina, manzur, elisa, bal, kier, joffé, progesterone, hormone, receptor, open, cell, transgenic, author, buenos, aires, data, information, log,

Topics {✒️}

month download article/chapter hormone-sensitive breast cancer slobodanka klein proto-neu transgenic model tpr-met oncogene leads innate immune cells related subjects randomized controlled trial unirradiated epithelial cells breast cancer incidence breast cancer progression full article pdf immune competent mice privacy choices/manage cookies human breast carcinomas mammary adenocarcinomas induced study hormone-responsiveness transgenic mouse model hormone-independent tumor spontaneous estrogen dependent premalignant mammary progression m05 mammary tumor balancing immune response ovariectomized female mice breast cancer pleural effusion derived article simian european economic area semi-differentiated adenocarcinoma physiologically relevant setting national academy press excellent technical assistance bid 1728/oc-ar instituto universitario cemic estrogen receptor expression vivo spontaneous model estrogen receptor characterization human cell line conditions privacy policy androgen receptor expression m05 tumor showed marina simian virgin female balb/ check access instant access human breast accepting optional cookies article log author correspondence breast carcinoma

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         description:Currently, an in vivo spontaneous model of estrogen dependent, tamoxifen sensitive breast cancer does not exist. We show here the characterization of the M05 mammary tumor that appeared spontaneously in a 1-year-old virgin female BALB/c mouse in our animal facility. The M05 tumor is a semi-differentiated adenocarcinoma that expresses estrogen and progesterone receptors. When it was transplanted to either male or ovariectomized female mice it did not grow. Moreover, ovariectomy or treatment with tamoxifen of tumor bearing mice led to a halt in tumor growth. Treatment of ovariectomized mice that had been inoculated with the M05 tumor showed that only estradiol, but not progesterone, promoted the re-growth of the tumor. Finally, after passage nine, tumor growth was achieved in male and ovariectomized female mice suggesting that the tumor had progressed to hormone independence. However, like often found in the clinic, expression of estrogen and progesterone receptors was maintained. This model mimics the biology of estrogen receptor positive breast cancer in humans and presents itself as an invaluable tool for the study of endocrine resistance in a physiologically relevant setting.
         datePublished:2008-01-09T00:00:00Z
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            Estrogen dependent
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            In vivo mouse model
            Oncology
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      headline:A spontaneous estrogen dependent, tamoxifen sensitive mouse mammary tumor: a new model system to study hormone-responsiveness in immune competent mice
      description:Currently, an in vivo spontaneous model of estrogen dependent, tamoxifen sensitive breast cancer does not exist. We show here the characterization of the M05 mammary tumor that appeared spontaneously in a 1-year-old virgin female BALB/c mouse in our animal facility. The M05 tumor is a semi-differentiated adenocarcinoma that expresses estrogen and progesterone receptors. When it was transplanted to either male or ovariectomized female mice it did not grow. Moreover, ovariectomy or treatment with tamoxifen of tumor bearing mice led to a halt in tumor growth. Treatment of ovariectomized mice that had been inoculated with the M05 tumor showed that only estradiol, but not progesterone, promoted the re-growth of the tumor. Finally, after passage nine, tumor growth was achieved in male and ovariectomized female mice suggesting that the tumor had progressed to hormone independence. However, like often found in the clinic, expression of estrogen and progesterone receptors was maintained. This model mimics the biology of estrogen receptor positive breast cancer in humans and presents itself as an invaluable tool for the study of endocrine resistance in a physiologically relevant setting.
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         Oncology
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