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cancer, breast, google, scholar, article, pubmed, cas, risk, women, factors, epidemiol, millikan, newman, basallike, study, res, epidemiology, receptor, molecular, africanamerican, usa, carolina, prev, university, research, perou, subtypes, white, breastfeeding, natl, health, department, moorman, populationbased, expression, biomarkers, status, school, data, luminal, access, med, race, north, public, obesity, differences, analysis, treatment, subtype,

Topics {✒️}

month download article/chapter sarah nyante elevated waist-hip ratio her2/neu-overexpressing phenotypes paraffin-embedded tissue sections called triple-negative phenotype nih/nci p50-ca58223 term full-term pregnancy gene-expression-based predictors integrating population-based epidemiology gene expression analyses full article pdf brca1-related breast cancer immature cell type human breast tumours intrinsic molecular signature premenopausal african-american women young african-american women population-based series breast tumor subtypes shelton earp & charles privacy choices/manage cookies breast cancer subtypes hormone-related factors younger african-american women gene expression patterns breast ductal carcinoma invasive breast carcinoma 1007/s10549-007-9790-6 rights immunohistochemistry core facility population attributable fraction hormone receptor status full-term pregnancy multiple risk factors metabolic risk factors population-based study breast cancer attributable breast cancer risk population-based cohort operable breast cancer breast cancer mortality lethal breast cancer breast cancer worse 2/neu oncogene amplification progesterone receptor status poulation attributable risk related subjects health-related variables visceral adipose tissue basal cytokeratins expression

Questions {❓}

• Blackman D, Masi C (2006) Racial and ethnic disparities in breast cancer mortality: are we doing enough to address the root causes?

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         headline:Epidemiology of basal-like breast cancer
         description:Risk factors for the newly identified “intrinsic” breast cancer subtypes (luminal A, luminal B, basal-like and human epidermal growth factor receptor 2-positive/estrogen receptor-negative) were determined in the Carolina Breast Cancer Study, a population-based, case–control study of African-American and white women. Immunohistochemical markers were used to subtype 1,424 cases of invasive and in situ breast cancer, and case subtypes were compared to 2,022 controls. Luminal A, the most common subtype, exhibited risk factors typically reported for breast cancer in previous studies, including inverse associations for increased parity and younger age at first full-term pregnancy. Basal-like cases exhibited several associations that were opposite to those observed for luminal A, including increased risk for parity and younger age at first term full-term pregnancy. Longer duration breastfeeding, increasing number of children breastfed, and increasing number of months breastfeeding per child were each associated with reduced risk of basal-like breast cancer, but not luminal A. Women with multiple live births who did not breastfeed and women who used medications to suppress lactation were at increased risk of basal-like, but not luminal A, breast cancer. Elevated waist-hip ratio was associated with increased risk of luminal A in postmenopausal women, and increased risk of basal-like breast cancer in pre- and postmenopausal women. The prevalence of basal-like breast cancer was highest among premenopausal African-American women, who also showed the highest prevalence of basal-like risk factors. Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity.
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      headline:Epidemiology of basal-like breast cancer
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            name:University of North Carolina
            address:
               name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
            name:University of North Carolina
            address:
               name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Sarah Nyante
      affiliation:
            name:University of North Carolina
            address:
               name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Chad Livasy
      affiliation:
            name:University of North Carolina
            address:
               name:Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Lisa Carey
      affiliation:
            name:University of North Carolina
            address:
               name:Department of Oncology, School of Medicine, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:H. Shelton Earp
      affiliation:
            name:University of North Carolina
            address:
               name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Charles M. Perou
      affiliation:
            name:University of North Carolina
            address:
               name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
            name:University of North Carolina
            address:
               name:Department of Genetics, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
      name:School of Public Health, Queensland University of Technology, Kelvin Grove, Australia
      name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
      name:Department of Community and Family Medicine, School of Medicine, Duke University, Durham, USA
      name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
      name:Division of Chronic Disease and Injury Prevention, Department of Public Health, Los Angeles County, Los Angeles, USA
      name:Department of Epidemiology, School of Public Health, University of California, Los Angeles, USA
      name:Center for Infant and Young Child Feeding and Care, Department of Maternal and Child Health, School of Public Health, University of North Carolina, Chapel Hill, USA
      name:Department of Pathology, School of Medicine, Duke University, Durham, USA
      name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
      name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
      name:Department of Epidemiology, CB #7435, School of Public Health, University of North Carolina, Chapel Hill, USA
      name:Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, USA
      name:Department of Oncology, School of Medicine, University of North Carolina, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
      name:Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, USA
      name:Department of Genetics, University of North Carolina, Chapel Hill, USA
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