We are analyzing https://link.springer.com/article/10.1007/s10549-006-9292-y.

Title:
Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women | Breast Cancer Research and Treatment
Description:
The incidence of breast cancer varies among women living in the Southwestern part of the US. We evaluate how body size influences breast cancer risk among these women. Cases (n =  2,325) diagnosed with breast cancer between October 1, 1999 and May 2004 residing in Arizona, Colorado, New Mexico, or Utah were matched to controls (n = 2,525). Participants were interviewed; height, weight, waist, and hip circumference were measured at the time of interview; blood was drawn. A large body mass index (BMI) at age 15 was inversely associated with pre-menopausal breast cancer risk in both non-Hispanic white (NHW) and Hispanic women (Odds ratio, ORs 0.68 95% CI 0.44, 1.04, and 0.65 95% CI 0.39, 1.08, respectively); BMI at age 15 also had an impact on subsequent breast cancer associated with obesity after menopause. Among post-menopausal women, recent exposure to hormones was an important modifier of risk associated with body size. Among women not recently exposed to hormones risk associated with obesity was 1.61 (95% CI 1.05, 2.45) for NHW women; gaining ≥25 kg between 15 and age 50 was inversely associated with breast cancer among Hispanic women (OR 0.51, 95% CI 0.23, 1.14). A large weight gain and a large waist-to-hip ratio (WHR) was associated with an increased odds of having an estrogen receptor negative tumor among NHW only (OR 1.81, 95% CI 1.07, 3.08, and 2.04 95% CI 1.20,3.50). These findings suggest that the metabolic consequences of obesity on breast cancer risk differ between NHW and Hispanic women living in the Southwest.
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Keywords {🔍}

cancer, google, scholar, article, pubmed, breast, cas, risk, women, weight, body, study, slattery, baumgartner, obesity, hispanic, white, health, nonhispanic, epidemiol, research, size, activity, data, change, edwards, mexico, estrogen, american, ratio, physical, med, genet, usa, privacy, cookies, content, european, fat, sweeney, premenopausal, nhw, postmenopausal, receptor, access, key, prospective, admixture, hum, genetic,

Topics {✒️}

month download article/chapter c-reactive protein correlate lower body-mass index long-term weight change waist/hip ratio van noord pa case-control study evaluating obesity-related insulin resistance full article pdf cancer prevention program european genetic admixture adult bmi change privacy choices/manage cookies related subjects prevention national program large weight gain body mass index aging-related phenotypes asthma-related phenotypes breast cancer risk hip ratio icelandic admixture problem kathy baumgartner richard baumgartner breast cancer varies subsequent breast cancer premenopausal breast cancer breast cancer survivors breast cancer survival van gils ch cardiovascular health study treatment center epidemiology moffitt cancer center postmenopausal breast cancer mexico tumor registry rancho bernardo study implementing study protocol growth factor axis additional state support obesity-induced inflammatory national cancer institute multilocus genotype data data collection efforts puerto rican asthmatics correlated allele frequencies cavalli-sforza ll interviewer performance evaluation long term consequences salt lake city european economic area

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         headline:Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women
         description:The incidence of breast cancer varies among women living in the Southwestern part of the US. We evaluate how body size influences breast cancer risk among these women. Cases (n = 2,325) diagnosed with breast cancer between October 1, 1999 and May 2004 residing in Arizona, Colorado, New Mexico, or Utah were matched to controls (n = 2,525). Participants were interviewed; height, weight, waist, and hip circumference were measured at the time of interview; blood was drawn. A large body mass index (BMI) at age 15 was inversely associated with pre-menopausal breast cancer risk in both non-Hispanic white (NHW) and Hispanic women (Odds ratio, ORs 0.68 95% CI 0.44, 1.04, and 0.65 95% CI 0.39, 1.08, respectively); BMI at age 15 also had an impact on subsequent breast cancer associated with obesity after menopause. Among post-menopausal women, recent exposure to hormones was an important modifier of risk associated with body size. Among women not recently exposed to hormones risk associated with obesity was 1.61 (95% CI 1.05, 2.45) for NHW women; gaining ≥25 kg between 15 and age 50 was inversely associated with breast cancer among Hispanic women (OR 0.51, 95% CI 0.23, 1.14). A large weight gain and a large waist-to-hip ratio (WHR) was associated with an increased odds of having an estrogen receptor negative tumor among NHW only (OR 1.81, 95% CI 1.07, 3.08, and 2.04 95% CI 1.20,3.50). These findings suggest that the metabolic consequences of obesity on breast cancer risk differ between NHW and Hispanic women living in the Southwest.
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      headline:Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women
      description:The incidence of breast cancer varies among women living in the Southwestern part of the US. We evaluate how body size influences breast cancer risk among these women. Cases (n = 2,325) diagnosed with breast cancer between October 1, 1999 and May 2004 residing in Arizona, Colorado, New Mexico, or Utah were matched to controls (n = 2,525). Participants were interviewed; height, weight, waist, and hip circumference were measured at the time of interview; blood was drawn. A large body mass index (BMI) at age 15 was inversely associated with pre-menopausal breast cancer risk in both non-Hispanic white (NHW) and Hispanic women (Odds ratio, ORs 0.68 95% CI 0.44, 1.04, and 0.65 95% CI 0.39, 1.08, respectively); BMI at age 15 also had an impact on subsequent breast cancer associated with obesity after menopause. Among post-menopausal women, recent exposure to hormones was an important modifier of risk associated with body size. Among women not recently exposed to hormones risk associated with obesity was 1.61 (95% CI 1.05, 2.45) for NHW women; gaining ≥25 kg between 15 and age 50 was inversely associated with breast cancer among Hispanic women (OR 0.51, 95% CI 0.23, 1.14). A large weight gain and a large waist-to-hip ratio (WHR) was associated with an increased odds of having an estrogen receptor negative tumor among NHW only (OR 1.81, 95% CI 1.07, 3.08, and 2.04 95% CI 1.20,3.50). These findings suggest that the metabolic consequences of obesity on breast cancer risk differ between NHW and Hispanic women living in the Southwest.
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         Waist-to-hip ratio
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