We are analyzing https://link.springer.com/article/10.1007/s10549-005-9067-x.

Title:
From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies | Breast Cancer Research and Treatment
Description:
Numerous mouse models of mammary cancer have been developed that mimic selective aspects of human disease. The use of these models has enabled preclinical chemotherapeutic, chemoprevention, and genetic therapy studies in vivo, the testing of gene delivery systems, and the identification of tumour and metastasis suppressor and inducer genes. This review has discussed the most abundantly used murine models of mammary cancer including: spontaneous tumours, chemically induced tumours, orthotopic and syngeneic tumour transplantation, injected tumours, and genetically engineered mice with a predisposition to neoplasia. Each model has been discussed with regards to its merits and limitations for investigating the genetic and phenotypic alterations involved in the human disease as well as its potential usefulness for the development of new treatment strategies. To date no single mouse model is available with the ability to replicate the entire disease process, however, existing models continue to provide invaluable insights into breast cancer induction and progression that would be impossible to obtain using in vitro models alone.
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Keywords {🔍}

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Topics {✒️}

accelerates c-myc-induced tumorigenesis c-myc-induced mammary carcinogenesis month download article/chapter c-myc-induced tumorigenesis int-2 proto-oncogenes cooperate ndf/heregulin induces persistence human papillomavirus-induced carcinogenesis node-negative breast cancer extracellular signal-regulated kinase mammary-specific model demonstrates antigen transgenic mice estrogen receptor alpha-positive neu proto-oncogene involved tumor–bone cellular interactions secretory epithelial cells local tumor invasion full article pdf metastatic bone disease transgenic mouse model human breast cancer experimental metastatic properties breast cancer cells premalignant breast disease primary breast cancer nude mice int related subjects metastatic tumor growth breast cancer metastasis gene delivery systems mammary cancer including postoperative adjuvant therapy 2/neu proto-oncogene human tumor xenografts successive tumour lines tumour lines implanted transgenic mice carrying transgenic mice embo transgenic mice results breast cancer genetics keywords breast cancer single mouse model privacy choices/manage cookies artificially induced metastasis hormone-independent tumor entire disease process athymic nude mice truncated int3 gene mammary gland involution /sv40 large sandgren ep

Questions {❓}

Slamon DJ, Clark GM, Amplification of c-erbB-2 and aggressive human breast tumors?
Wagner KU, Models of breast cancer: quo vadis, animal modeling?

Schema {🗺️}

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