We are analyzing https://link.springer.com/article/10.1007/s10549-004-2184-0.

Title:
Efficacy of weekly paclitaxel in patients with docetaxel-resistant metastatic breast cancer | Breast Cancer Research and Treatment
Description:
Background. Partial cross-resistance to paclitaxel and docetaxel has been demonstrated in pre-clinical studies. Patients and methods. We retrospectively evaluated the efficacy of weekly paclitaxel 80 mg/m2 in 82 patients with docetaxel-resisitant metastatic breast cancer. Docetaxel resistance was classified into primary resistance, defined as progressive disease while receiving docetaxel, and secondary resistance, defined as progression after achievement of a documented clinical response to docetaxel. Secondary resistance was subclassified according to the interval between the final infusion of docetaxel and the start of weekly paclitaxel into: (1) short interval, ≦120 days, and (2) long interval, >120 days. Results. The response rate of the 82 patients was 19.5% (95% confidence interval, 10.8–27.9%). The response rate according to the docetaxel resistance category was: primary resistance (n=24), 8.3%; secondary resistance (n=58), 24.1% (short interval [n=39], 17.9%, and long interval, [n=19], 36.8%). The differences in response rates among the three categories were statistically significant (p=0.0247, Cochran–Mantel–Haenszel test). The interval between from the final docetaxel infusion and disease progression were predictors for response of weekly paclitaxel. Conclusion. Weekly paclitaxel is modestly effective and safe in docetaxel-resistant metastatic breast cancer patients. However, weekly paclitaxel should not be recommended for primary resistance patients with docetaxel.
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cancer, breast, docetaxel, google, scholar, pubmed, cas, paclitaxel, patients, metastatic, resistance, article, oncol, weekly, clin, efficacy, phase, treatment, interval, research, study, taxol, privacy, cookies, content, yasuhiro, response, access, publish, search, katsumata, uno, advanced, horwitz, res, author, data, information, log, journal, docetaxelresistant, yonemori, hajime, ando, fujiwara, primary, secondary, safety, discover, chemotherapy,

Topics {✒️}

anthracenedione-resistant breast cancer month download article/chapter world health organization metastatic breast cancer cochran–mantel–haenszel test fant sb horwitz ringel sb horwitz hajime uno dose-dense therapy asmar gn hortobagyi real-world study gika ma dimopoulos advanced anthracycline-resistant docetaxel resistance category privacy choices/manage cookies partial cross-resistance multidrug resistance protein breast cancer full article pdf related subjects author correspondence docetaxel successfully treated dual her2 blockade medical oncology division phase ii study primary resistance patients dose-escalation study randomized phase ii pre-clinical studies weekly paclitaxel int single-agent docetaxel check access evidence-based review exogenous guanosine 5′-triphospahate sutherland jl misset kane wa bierman buchholz ef smit kalofonos la moulopoulos seeber ym rustum instant access anthracycline resistance paclitaxel-induced remission paclitaxel-pretreated previously discontinued patients conditions privacy policy docetaxel resistance european economic area line chemotherapy yasuhiro fujiwara final docetaxel infusion

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         headline:Efficacy of weekly paclitaxel in patients with docetaxel-resistant metastatic breast cancer
         description: Background. Partial cross-resistance to paclitaxel and docetaxel has been demonstrated in pre-clinical studies. Patients and methods. We retrospectively evaluated the efficacy of weekly paclitaxel 80 mg/m2 in 82 patients with docetaxel-resisitant metastatic breast cancer. Docetaxel resistance was classified into primary resistance, defined as progressive disease while receiving docetaxel, and secondary resistance, defined as progression after achievement of a documented clinical response to docetaxel. Secondary resistance was subclassified according to the interval between the final infusion of docetaxel and the start of weekly paclitaxel into: (1) short interval, ≦120 days, and (2) long interval, >120 days. Results. The response rate of the 82 patients was 19.5% (95% confidence interval, 10.8–27.9%). The response rate according to the docetaxel resistance category was: primary resistance (n=24), 8.3%; secondary resistance (n=58), 24.1% (short interval [n=39], 17.9%, and long interval, [n=19], 36.8%). The differences in response rates among the three categories were statistically significant (p=0.0247, Cochran–Mantel–Haenszel test). The interval between from the final docetaxel infusion and disease progression were predictors for response of weekly paclitaxel. Conclusion. Weekly paclitaxel is modestly effective and safe in docetaxel-resistant metastatic breast cancer patients. However, weekly paclitaxel should not be recommended for primary resistance patients with docetaxel.
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            predictive factor
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      headline:Efficacy of weekly paclitaxel in patients with docetaxel-resistant metastatic breast cancer
      description: Background. Partial cross-resistance to paclitaxel and docetaxel has been demonstrated in pre-clinical studies. Patients and methods. We retrospectively evaluated the efficacy of weekly paclitaxel 80 mg/m2 in 82 patients with docetaxel-resisitant metastatic breast cancer. Docetaxel resistance was classified into primary resistance, defined as progressive disease while receiving docetaxel, and secondary resistance, defined as progression after achievement of a documented clinical response to docetaxel. Secondary resistance was subclassified according to the interval between the final infusion of docetaxel and the start of weekly paclitaxel into: (1) short interval, ≦120 days, and (2) long interval, >120 days. Results. The response rate of the 82 patients was 19.5% (95% confidence interval, 10.8–27.9%). The response rate according to the docetaxel resistance category was: primary resistance (n=24), 8.3%; secondary resistance (n=58), 24.1% (short interval [n=39], 17.9%, and long interval, [n=19], 36.8%). The differences in response rates among the three categories were statistically significant (p=0.0247, Cochran–Mantel–Haenszel test). The interval between from the final docetaxel infusion and disease progression were predictors for response of weekly paclitaxel. Conclusion. Weekly paclitaxel is modestly effective and safe in docetaxel-resistant metastatic breast cancer patients. However, weekly paclitaxel should not be recommended for primary resistance patients with docetaxel.
      datePublished:
      dateModified:
      pageStart:237
      pageEnd:241
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         metastatic breast cancer
         paclitaxel
         predictive factor
         resistance
         taxane
         Oncology
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