We are analyzing https://link.springer.com/article/10.1007/s10534-011-9476-8.

Title:
Glutathione: a key component of the cytoplasmic labile iron pool | BioMetals
Description:
The cytoplasmic labile iron pool supplies iron to the mitochondrion for heme and iron sulfur cluster synthesis and to many cytoplasmic enzymes, thereby controlling numerous metabolic reactions. Surprisingly the chemical nature of this pool has never been convincingly characterised. Here we provide evidence for iron(II)glutathione being the dominant component of this pool. We report for the first time the affinity constant for the glutathione–iron(II) interaction and use this value to study the cytoplasmic speciation of iron(II). The formation of this complex is a major determinant of the electrode potential of the cytoplasmic ferrous iron pool, a means of selecting between iron(II) and manganese(II) and it provides a substrate for glutaredoxin/iron clusters at the dimer interface of glutaredoxins involved in the synthesis of Fe–S cluster proteins.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Real Estate

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

google, scholar, article, cas, pubmed, iron, chem, glutathione, pool, biol, cytoplasmic, cluster, content, hider, access, metal, biochem, privacy, cookies, labile, kong, fes, soc, cell, complexes, publish, search, nature, ironii, glutaredoxins, proteins, regulatory, cells, blood, metabolism, cellular, sci, nat, function, data, information, log, journal, research, biometals, component, robert, heme, reactions, intracellular,

Topics {✒️}

month download article/chapter [2fe–2s] cluster low-mr iron isolated glutaredoxin/iron clusters iron–sulfur cluster binding iron regulatory proteins intracellular cell controls article biometals aims full article pdf related subjects iron mitochondria photosystem privacy choices/manage cookies depleting cytosolic iron chelatable iron pool �chelatable iron pool” check access instant access iron responsive elements glutathione s-transferases nuclear glutathione cycle iron-citrate complexes glutaredoxin 5 deficiency cellular iron regulation expanding chemical biology european economic area naturally occurring substances equilibria involving soluble partially soluble species future drug design mammalian siderophore synthesised presently accepted levels recurrent febrile seizures riggs-gelasco pj regulators jelly rolled methodically defined quantity guinea pig reticulocytes ischemic pre conditioning dr wolfgang maret dr reinhard kissner franklin–wilkins building cytoplasmic pool glutathione peroxidase activity oxygen activation reactions article hider bacterial homolog involved saccharomyces cerevisiae provide function metal trafficking vertebrate iron metabolism article log

Questions {❓}

Kong XL, Zhou T, Neubert H, Liu Z, Hider RC (2009) 3-Hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one: a bidentate or tridentate iron(III) ligand?
Ozer A, Bruick RK (2007) Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Glutathione: a key component of the cytoplasmic labile iron pool
         description:The cytoplasmic labile iron pool supplies iron to the mitochondrion for heme and iron sulfur cluster synthesis and to many cytoplasmic enzymes, thereby controlling numerous metabolic reactions. Surprisingly the chemical nature of this pool has never been convincingly characterised. Here we provide evidence for iron(II)glutathione being the dominant component of this pool. We report for the first time the affinity constant for the glutathione–iron(II) interaction and use this value to study the cytoplasmic speciation of iron(II). The formation of this complex is a major determinant of the electrode potential of the cytoplasmic ferrous iron pool, a means of selecting between iron(II) and manganese(II) and it provides a substrate for glutaredoxin/iron clusters at the dimer interface of glutaredoxins involved in the synthesis of Fe–S cluster proteins.
         datePublished:2011-07-17T00:00:00Z
         dateModified:2011-07-17T00:00:00Z
         pageStart:1179
         pageEnd:1187
         sameAs:https://doi.org/10.1007/s10534-011-9476-8
         keywords:
            Iron
            Glutathione
            Cytoplasmic labile iron pool
            Biochemistry
            general
            Pharmacology/Toxicology
            Microbiology
            Cell Biology
            Plant Physiology
            Medicine/Public Health
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Sch1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig6_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig7_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig8_HTML.gif
         isPartOf:
            name:BioMetals
            issn:
               1572-8773
               0966-0844
            volumeNumber:24
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Robert C. Hider
               affiliation:
                     name:King’s College London
                     address:
                        name:Institute of Pharmaceutical Science, King’s College London, London, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Xiao L. Kong
               affiliation:
                     name:King’s College London
                     address:
                        name:Institute of Pharmaceutical Science, King’s College London, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Glutathione: a key component of the cytoplasmic labile iron pool
      description:The cytoplasmic labile iron pool supplies iron to the mitochondrion for heme and iron sulfur cluster synthesis and to many cytoplasmic enzymes, thereby controlling numerous metabolic reactions. Surprisingly the chemical nature of this pool has never been convincingly characterised. Here we provide evidence for iron(II)glutathione being the dominant component of this pool. We report for the first time the affinity constant for the glutathione–iron(II) interaction and use this value to study the cytoplasmic speciation of iron(II). The formation of this complex is a major determinant of the electrode potential of the cytoplasmic ferrous iron pool, a means of selecting between iron(II) and manganese(II) and it provides a substrate for glutaredoxin/iron clusters at the dimer interface of glutaredoxins involved in the synthesis of Fe–S cluster proteins.
      datePublished:2011-07-17T00:00:00Z
      dateModified:2011-07-17T00:00:00Z
      pageStart:1179
      pageEnd:1187
      sameAs:https://doi.org/10.1007/s10534-011-9476-8
      keywords:
         Iron
         Glutathione
         Cytoplasmic labile iron pool
         Biochemistry
         general
         Pharmacology/Toxicology
         Microbiology
         Cell Biology
         Plant Physiology
         Medicine/Public Health
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Sch1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig6_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig7_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-011-9476-8/MediaObjects/10534_2011_9476_Fig8_HTML.gif
      isPartOf:
         name:BioMetals
         issn:
            1572-8773
            0966-0844
         volumeNumber:24
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Robert C. Hider
            affiliation:
                  name:King’s College London
                  address:
                     name:Institute of Pharmaceutical Science, King’s College London, London, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Xiao L. Kong
            affiliation:
                  name:King’s College London
                  address:
                     name:Institute of Pharmaceutical Science, King’s College London, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:BioMetals
      issn:
         1572-8773
         0966-0844
      volumeNumber:24
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:King’s College London
      address:
         name:Institute of Pharmaceutical Science, King’s College London, London, UK
         type:PostalAddress
      name:King’s College London
      address:
         name:Institute of Pharmaceutical Science, King’s College London, London, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Robert C. Hider
      affiliation:
            name:King’s College London
            address:
               name:Institute of Pharmaceutical Science, King’s College London, London, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Xiao L. Kong
      affiliation:
            name:King’s College London
            address:
               name:Institute of Pharmaceutical Science, King’s College London, London, UK
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Pharmaceutical Science, King’s College London, London, UK
      name:Institute of Pharmaceutical Science, King’s College London, London, UK
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(148)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.46s.

LINK . SPRINGER . COM {}