We are analyzing https://link.springer.com/article/10.1007/s10534-006-9063-6.

Title:
Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: The ferritin story | BioMetals
Description:
Combinations of DNA antioxidant response element and mRNA iron responsive element regulate ferritin expression in animals in response to oxidant and iron stress, or normal developmental signals. Ferritins are protein nanocages, found in animals, plants, bacteria, and archaea, that convert iron and oxygen to ferric oxy biominerals in the protein central cavity; the mineral traps potentially toxic reactants and concentrates iron for the future synthesis of other iron/heme proteins. Regulatory signals and the nanocage gene products are the same throughout biology, but the genetic mechanisms, DNA versus DNA + mRNA, vary. The number of genes, temporal regulation, tissue distribution in multi-cellular organisms, and gene product size (maxi-ferritins have 24 subunits and mini-ferritins, or Dps proteins, have 12 subunits and are restricted to bacteria and archaea) suggest an overwhelming diversity and variability. However, common themes of regulation and function are described which indicate not only that the three-dimensional protein structure and the functions of the ferritins are conserved, but also that broad features of genetic regulation are conserved relative to organismal and/or community needs. The analysis illustrates the centrality of the ferritins to life with iron and oxygen and models how Nature harnesses potentially dangerous chemistry for biology.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

article, google, scholar, cas, pubmed, iron, ferritin, theil, biol, protein, regulatory, regulation, chem, mrna, gene, usa, sci, element, structure, plant, acad, dna, expression, proteins, binding, proc, natl, oxygen, ferritins, genes, rna, mol, cells, content, stress, privacy, cookies, research, biometals, responses, antioxidant, response, bacteria, dps, soybean, cell, function, analysis, publish, search,

Topics {✒️}

starvation-induced dps/pexb-homologous gene month download article/chapter iso-iron responsive elements conserved iron-responsive elements nf-e2-related factors base-paired flanking regions protein-coated iron minerals metal-catalysed histidine oxidation cap-binding complex eif4f iron-sulphur cluster biogenesis nuclear receptor-coactivator interactions ferritin gene transcription long-term iron overload iron-responsive degradation ire/irp regulatory system nanocage gene products iron regulatory proteins full article pdf iron-dependent regulation iron regulatory element internal loop/bulge structure dna-binding protein antioxidant response element article biometals aims iron-regulatory protein 1 iron-regulatory protein 2 anthracis dps proteins gene product size privacy choices/manage cookies iron/heme proteins heme oxygenase-1 gene siderophore-mediated upregulation iron-controlling genes rna binding sites rna binding form cytoprotective antioxidant strategem protein central cavity opening protein pores related subjects coordinating responses mrna loop/bulge arabidopsis ferritin expression metal ion stress mrna elements cellular iron homeostasis mitochondrial iron homeostasis european economic area ferric oxy biominerals erwinia chrysanthemi infection hypoxia-inducible repressor

Questions {❓}

Grotz N, Guerinot ML (2002) Limiting nutrients: an old problem with new solutions?
Ke Y, Wu J, Leibold EA, Walden WE, Theil EC (1998) Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding: fine-tuning of mRNA regulation?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: The ferritin story
         description:Combinations of DNA antioxidant response element and mRNA iron responsive element regulate ferritin expression in animals in response to oxidant and iron stress, or normal developmental signals. Ferritins are protein nanocages, found in animals, plants, bacteria, and archaea, that convert iron and oxygen to ferric oxy biominerals in the protein central cavity; the mineral traps potentially toxic reactants and concentrates iron for the future synthesis of other iron/heme proteins. Regulatory signals and the nanocage gene products are the same throughout biology, but the genetic mechanisms, DNA versus DNA + mRNA, vary. The number of genes, temporal regulation, tissue distribution in multi-cellular organisms, and gene product size (maxi-ferritins have 24 subunits and mini-ferritins, or Dps proteins, have 12 subunits and are restricted to bacteria and archaea) suggest an overwhelming diversity and variability. However, common themes of regulation and function are described which indicate not only that the three-dimensional protein structure and the functions of the ferritins are conserved, but also that broad features of genetic regulation are conserved relative to organismal and/or community needs. The analysis illustrates the centrality of the ferritins to life with iron and oxygen and models how Nature harnesses potentially dangerous chemistry for biology.
         datePublished:2007-01-09T00:00:00Z
         dateModified:2007-01-09T00:00:00Z
         pageStart:513
         pageEnd:521
         sameAs:https://doi.org/10.1007/s10534-006-9063-6
         keywords:
            Oxygen
            Ferritin
            Dps protein
            Antioxidant response (ARE) genes
            mRNA (IRE) regulation
            Biochemistry
            general
            Pharmacology/Toxicology
            Microbiology
            Cell Biology
            Plant Physiology
            Medicine/Public Health
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-006-9063-6/MediaObjects/10534_2006_9063_Fig1_HTML.gif
         isPartOf:
            name:BioMetals
            issn:
               1572-8773
               0966-0844
            volumeNumber:20
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Elizabeth C. Theil
               affiliation:
                     name:CHORI (Children’s Hospital Oakland Research Institute)
                     address:
                        name:CHORI (Children’s Hospital Oakland Research Institute), Oakland, USA
                        type:PostalAddress
                     type:Organization
                     name:University of California
                     address:
                        name:Department of Nutritional Science and Toxicology, University of California, Berkeley, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Coordinating responses to iron and oxygen stress with DNA and mRNA promoters: The ferritin story
      description:Combinations of DNA antioxidant response element and mRNA iron responsive element regulate ferritin expression in animals in response to oxidant and iron stress, or normal developmental signals. Ferritins are protein nanocages, found in animals, plants, bacteria, and archaea, that convert iron and oxygen to ferric oxy biominerals in the protein central cavity; the mineral traps potentially toxic reactants and concentrates iron for the future synthesis of other iron/heme proteins. Regulatory signals and the nanocage gene products are the same throughout biology, but the genetic mechanisms, DNA versus DNA + mRNA, vary. The number of genes, temporal regulation, tissue distribution in multi-cellular organisms, and gene product size (maxi-ferritins have 24 subunits and mini-ferritins, or Dps proteins, have 12 subunits and are restricted to bacteria and archaea) suggest an overwhelming diversity and variability. However, common themes of regulation and function are described which indicate not only that the three-dimensional protein structure and the functions of the ferritins are conserved, but also that broad features of genetic regulation are conserved relative to organismal and/or community needs. The analysis illustrates the centrality of the ferritins to life with iron and oxygen and models how Nature harnesses potentially dangerous chemistry for biology.
      datePublished:2007-01-09T00:00:00Z
      dateModified:2007-01-09T00:00:00Z
      pageStart:513
      pageEnd:521
      sameAs:https://doi.org/10.1007/s10534-006-9063-6
      keywords:
         Oxygen
         Ferritin
         Dps protein
         Antioxidant response (ARE) genes
         mRNA (IRE) regulation
         Biochemistry
         general
         Pharmacology/Toxicology
         Microbiology
         Cell Biology
         Plant Physiology
         Medicine/Public Health
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10534-006-9063-6/MediaObjects/10534_2006_9063_Fig1_HTML.gif
      isPartOf:
         name:BioMetals
         issn:
            1572-8773
            0966-0844
         volumeNumber:20
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Elizabeth C. Theil
            affiliation:
                  name:CHORI (Children’s Hospital Oakland Research Institute)
                  address:
                     name:CHORI (Children’s Hospital Oakland Research Institute), Oakland, USA
                     type:PostalAddress
                  type:Organization
                  name:University of California
                  address:
                     name:Department of Nutritional Science and Toxicology, University of California, Berkeley, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:BioMetals
      issn:
         1572-8773
         0966-0844
      volumeNumber:20
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:CHORI (Children’s Hospital Oakland Research Institute)
      address:
         name:CHORI (Children’s Hospital Oakland Research Institute), Oakland, USA
         type:PostalAddress
      name:University of California
      address:
         name:Department of Nutritional Science and Toxicology, University of California, Berkeley, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Elizabeth C. Theil
      affiliation:
            name:CHORI (Children’s Hospital Oakland Research Institute)
            address:
               name:CHORI (Children’s Hospital Oakland Research Institute), Oakland, USA
               type:PostalAddress
            type:Organization
            name:University of California
            address:
               name:Department of Nutritional Science and Toxicology, University of California, Berkeley, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:CHORI (Children’s Hospital Oakland Research Institute), Oakland, USA
      name:Department of Nutritional Science and Toxicology, University of California, Berkeley, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(207)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Foundation
Prism.js

4.2s.

LINK . SPRINGER . COM {}