We are analyzing https://link.springer.com/article/10.1007/s10529-011-0838-7.

Title:
Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes | Biotechnology Letters
Description:
Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.
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Keywords {🔍}

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Topics {✒️}

camp-response element-binding protein month download article/chapter b16-f1 murine melanocytes alpha-msh-induced melanogenesis sung-joon lee high-throughput q-pcr water-soluble puerarin glycosides hee-jin jun camp protein kinase dong-woo kim human melanocyte culture exhibits anti-melanogenic effects pka signaling pathway woo-duck seo full article pdf �cooperative research program privacy choices/manage cookies ethanolic extract inhibits protein kinase article lee gene expression profiling b16 cells stimulated real-time pcr human skin pigmentation european economic area terpenoid phytoalexin present body fat reduction melanocyte development van dolah fm factors influencing correlation conditions privacy policy melanogenesis protein kinase mitf-degrading agent key transcription factor accepting optional cookies inhibited tyrosinase activities main content log jasmonic acid mechanism natural cyclic terpene author information authors article log lee jh b16 melanocytes journal finder publish lee sj sung nj seo mj article cite human melanocytes rice bran

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         description:Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.
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      description:Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.
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