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LINK . SPRINGER . COM {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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We are analyzing https://link.springer.com/article/10.1007/s10522-022-09973-y.

Title:
Mitochondria-targeted senotherapeutic interventions | Biogerontology
Description:
Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the factors that make life difficult with aging, and on the other side are the products of human effort against these factors. The most important factors that make the life difficult with aging are age-related disorders. Developing senotherapeutic strategies may bring effective solutions for the sufferers of age-related disorders. Mitochondrial dysfunction comes first in elucidating the pathogenesis of age-related disorders and presenting appropriate treatment options. Although it has been widely accepted that mitochondrial dysfunction is a common characteristic of cellular senescence, it still remains unclear why dysfunctional mitochondria occupy a central position in the development senescence-associated secretory phenotype (SASP) related to age-related disorders. Mitochondrial dysfunction and SASP-related disease progression are closely interlinked to weaken immunity which is a common phenomenon in aging. A group of substances known as senotherapeutics targeted to senescent cells can be classified into two main groups: senolytics (kill senescent cells) and senomorphics/senostatics (suppress their SASP secretions) in order to extend health lifespan and potentially lifespan. As mitochondria are also closely related to the survival of senescent cells, using either mitochondria-targeted senolytic or redox modulator senomorphic strategies may help us to solve the complex problems with the detrimental consequences of cellular senescence. Killing of senescent cells and/or ameliorate their SASP-related negative effects are currently considered to be effective mitochondria-directed gerotherapeutic approaches for fighting against age-related disorders.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Business & Finance

Content Management System {📝}

What CMS is link.springer.com built with?


Link.springer.com is powered by SERENDIPITY.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,016 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, mitochondrial, aging, cell, senescence, mitochondria, mitochondriatargeted, httpsdoiorg, cells, mol, cellular, diseases, biol, delivery, httpsdoiorgs, redox, sci, çakatay, agerelated, treatment, targeted, drug, pharmacol, dysfunction, senescent, ageing, med, antioxidant, chem, function, strategies, chapter, springer, res, atayik, disease, antiaging, nat, targeting, ther, liu, heart, author, privacy, cookies,

Topics {✒️}

month download article/chapter mitochondria-targeted aromatic-cationic peptides mitochondria-targeted s-nitrosothiol protects mitochondria-targeted triphenylphosphonium-based compounds mitochondria-targeted senotherapeutic interventions 3-mercaptopyruvate sulfurtransferase/h2s pathway dl-α-lipoic acid post-infarct heart failure sh-sy5y cells exposed enhanced inter-compartmental ca dual function mito-porter targeting bcl-family proteins mitochondria-targeted macrocyclic mn mitochondria-targeted spin trap mitochondria-targeted hydrogen sulfide article biogerontology aims sasp-related negative effects mitochondria-targeted antioxidant therapy full article pdf retarding age-related diseases coq10-dependent redox activity mitochondria selective s-nitrosation sasp-related disease progression article atayik warraich u-e putative anti-aging drug skq1 ophthalmic solution privacy choices/manage cookies targeting mitochondrial metabolism improves vascular function mitochondria-targeted senolytic aging-induced proteinopathies mitochondria-targeted antioxidant replication proteins revealed endogenous hydrogen sulfide developing senotherapeutic strategies mitochondrial targeted strategies mitochondria-targeted agents mitochondria targeted catalase mitochondria-targeted antioxidants mitochondria targeted derivative central position central organelles mitochondria-targeted drug age-related disorders peptide-mediated delivery animal subjects performed bring effective solutions promote tissue regeneration mitochondrially targeted compounds

Questions {❓}

  • Von Zglinicki T, Wan T, Miwa S (2021) Senescence in post-mitotic cells: a driver of aging?

Schema {🗺️}

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         description:Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the factors that make life difficult with aging, and on the other side are the products of human effort against these factors. The most important factors that make the life difficult with aging are age-related disorders. Developing senotherapeutic strategies may bring effective solutions for the sufferers of age-related disorders. Mitochondrial dysfunction comes first in elucidating the pathogenesis of age-related disorders and presenting appropriate treatment options. Although it has been widely accepted that mitochondrial dysfunction is a common characteristic of cellular senescence, it still remains unclear why dysfunctional mitochondria occupy a central position in the development senescence-associated secretory phenotype (SASP) related to age-related disorders. Mitochondrial dysfunction and SASP-related disease progression are closely interlinked to weaken immunity which is a common phenomenon in aging. A group of substances known as senotherapeutics targeted to senescent cells can be classified into two main groups: senolytics (kill senescent cells) and senomorphics/senostatics (suppress their SASP secretions) in order to extend health lifespan and potentially lifespan. As mitochondria are also closely related to the survival of senescent cells, using either mitochondria-targeted senolytic or redox modulator senomorphic strategies may help us to solve the complex problems with the detrimental consequences of cellular senescence. Killing of senescent cells and/or ameliorate their SASP-related negative effects are currently considered to be effective mitochondria-directed gerotherapeutic approaches for fighting against age-related disorders.
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External Links {🔗}(520)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

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