We are analyzing https://link.springer.com/article/10.1007/s10517-012-1876-4.

Title:
Expression of Genes of Glutathione Transferase Isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in Tumor Cells during the Formation of Drug Resistance to Cisplatin | Bulletin of Experimental Biology and Medicine
Description:
We studied the expression of genes encoding glutathione-S-transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 during the development of the resistance of human erythroleukemia (K562), mammary adenocarcinoma (MCF-7) and ovary adenocarcinoma (SKOV-3) cells to cisplatin (CDDP). It was found that drug resistance development in all three strains of tumor cells is associated with signifi cant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant K562/CDDP and MCF-7/CDDP cells.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,603,724 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, pubmed, google, scholar, cas, expression, cells, drug, resistance, gene, access, privacy, cookies, content, cancer, information, publish, research, search, glutathione, isoforms, tumor, cisplatin, kalinina, biol, data, log, journal, genes, gstp, gsta, gstk, berozov, shtil, open, discover, rev, download, author, russia, springer, optional, personal, parties, policy, find, track, bulletin, experimental, biology,

Topics {✒️}

month download article/chapter byulleten’ eksperimental’noi biologii hgsta4 gene expression related subjects privacy choices/manage cookies full article pdf cisplatin genetics published european economic area cdkn2a gene conditions privacy policy check access instant access drug resistance development article bulletin accepting optional cookies mcf-7/cddp cells main content log bmc evol tumor cells resistant k562/cddp journal finder publish author correspondence article log drug resistance article cite cancer ther article kalinina privacy policy personal data russian academy books a optional cookies manage preferences expression data protection drug metab essential cookies cookies skip subscription content similar content medicine aims institution subscribe journal publish usage analysis social media varying standards experimental biology resistance human erythroleukemia mammary adenocarcinoma

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Expression of Genes of Glutathione Transferase Isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in Tumor Cells during the Formation of Drug Resistance to Cisplatin
         description:We studied the expression of genes encoding glutathione-S-transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 during the development of the resistance of human erythroleukemia (K562), mammary adenocarcinoma (MCF-7) and ovary adenocarcinoma (SKOV-3) cells to cisplatin (CDDP). It was found that drug resistance development in all three strains of tumor cells is associated with signifi cant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant K562/CDDP and MCF-7/CDDP cells.
         datePublished:2012-11-23T00:00:00Z
         dateModified:2012-11-23T00:00:00Z
         pageStart:64
         pageEnd:67
         sameAs:https://doi.org/10.1007/s10517-012-1876-4
         keywords:
            drug resistance of tumor cells
            gene expression
            glutathione-S-transferase isoforms
            cisplatin
            Biomedicine
            general
            Internal Medicine
            Cell Biology
            Pathology
            Laboratory Medicine
         image:
         isPartOf:
            name:Bulletin of Experimental Biology and Medicine
            issn:
               1573-8221
               0007-4888
            volumeNumber:154
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:E. V. Kalinina
               affiliation:
                     name:People’s Friendship University of Russia
                     address:
                        name:People’s Friendship University of Russia, Moсква, Russia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:T. T. Berozov
               affiliation:
                     name:People’s Friendship University of Russia
                     address:
                        name:People’s Friendship University of Russia, Moсква, Russia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:A. A. Shtil
               affiliation:
                     name:Russian Academy of Medical Sciences
                     address:
                        name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:N. N. Chernov
               affiliation:
                     name:People’s Friendship University of Russia
                     address:
                        name:People’s Friendship University of Russia, Moсква, Russia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:V. A. Glasunova
               affiliation:
                     name:Russian Academy of Medical Sciences
                     address:
                        name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. D. Novichkova
               affiliation:
                     name:People’s Friendship University of Russia
                     address:
                        name:People’s Friendship University of Russia, Moсква, Russia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:N. K. Nurmuradov
               affiliation:
                     name:People’s Friendship University of Russia
                     address:
                        name:People’s Friendship University of Russia, Moсква, Russia
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Expression of Genes of Glutathione Transferase Isoforms GSTP1-1, GSTA4-4, and GSTK1-1 in Tumor Cells during the Formation of Drug Resistance to Cisplatin
      description:We studied the expression of genes encoding glutathione-S-transferase isoforms GSTP1-1, GSTA4-4, and GSTK1-1 during the development of the resistance of human erythroleukemia (K562), mammary adenocarcinoma (MCF-7) and ovary adenocarcinoma (SKOV-3) cells to cisplatin (CDDP). It was found that drug resistance development in all three strains of tumor cells is associated with signifi cant increase in hGSTP1 and hGSTA4 gene expression, whereas increased hGSTK1 gene expression was detected only in resistant K562/CDDP and MCF-7/CDDP cells.
      datePublished:2012-11-23T00:00:00Z
      dateModified:2012-11-23T00:00:00Z
      pageStart:64
      pageEnd:67
      sameAs:https://doi.org/10.1007/s10517-012-1876-4
      keywords:
         drug resistance of tumor cells
         gene expression
         glutathione-S-transferase isoforms
         cisplatin
         Biomedicine
         general
         Internal Medicine
         Cell Biology
         Pathology
         Laboratory Medicine
      image:
      isPartOf:
         name:Bulletin of Experimental Biology and Medicine
         issn:
            1573-8221
            0007-4888
         volumeNumber:154
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:E. V. Kalinina
            affiliation:
                  name:People’s Friendship University of Russia
                  address:
                     name:People’s Friendship University of Russia, Moсква, Russia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:T. T. Berozov
            affiliation:
                  name:People’s Friendship University of Russia
                  address:
                     name:People’s Friendship University of Russia, Moсква, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. A. Shtil
            affiliation:
                  name:Russian Academy of Medical Sciences
                  address:
                     name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:N. N. Chernov
            affiliation:
                  name:People’s Friendship University of Russia
                  address:
                     name:People’s Friendship University of Russia, Moсква, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:V. A. Glasunova
            affiliation:
                  name:Russian Academy of Medical Sciences
                  address:
                     name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. D. Novichkova
            affiliation:
                  name:People’s Friendship University of Russia
                  address:
                     name:People’s Friendship University of Russia, Moсква, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:N. K. Nurmuradov
            affiliation:
                  name:People’s Friendship University of Russia
                  address:
                     name:People’s Friendship University of Russia, Moсква, Russia
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Bulletin of Experimental Biology and Medicine
      issn:
         1573-8221
         0007-4888
      volumeNumber:154
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:People’s Friendship University of Russia
      address:
         name:People’s Friendship University of Russia, Moсква, Russia
         type:PostalAddress
      name:People’s Friendship University of Russia
      address:
         name:People’s Friendship University of Russia, Moсква, Russia
         type:PostalAddress
      name:Russian Academy of Medical Sciences
      address:
         name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
         type:PostalAddress
      name:People’s Friendship University of Russia
      address:
         name:People’s Friendship University of Russia, Moсква, Russia
         type:PostalAddress
      name:Russian Academy of Medical Sciences
      address:
         name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
         type:PostalAddress
      name:People’s Friendship University of Russia
      address:
         name:People’s Friendship University of Russia, Moсква, Russia
         type:PostalAddress
      name:People’s Friendship University of Russia
      address:
         name:People’s Friendship University of Russia, Moсква, Russia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:E. V. Kalinina
      affiliation:
            name:People’s Friendship University of Russia
            address:
               name:People’s Friendship University of Russia, Moсква, Russia
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:T. T. Berozov
      affiliation:
            name:People’s Friendship University of Russia
            address:
               name:People’s Friendship University of Russia, Moсква, Russia
               type:PostalAddress
            type:Organization
      name:A. A. Shtil
      affiliation:
            name:Russian Academy of Medical Sciences
            address:
               name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
               type:PostalAddress
            type:Organization
      name:N. N. Chernov
      affiliation:
            name:People’s Friendship University of Russia
            address:
               name:People’s Friendship University of Russia, Moсква, Russia
               type:PostalAddress
            type:Organization
      name:V. A. Glasunova
      affiliation:
            name:Russian Academy of Medical Sciences
            address:
               name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
               type:PostalAddress
            type:Organization
      name:M. D. Novichkova
      affiliation:
            name:People’s Friendship University of Russia
            address:
               name:People’s Friendship University of Russia, Moсква, Russia
               type:PostalAddress
            type:Organization
      name:N. K. Nurmuradov
      affiliation:
            name:People’s Friendship University of Russia
            address:
               name:People’s Friendship University of Russia, Moсква, Russia
               type:PostalAddress
            type:Organization
PostalAddress:
      name:People’s Friendship University of Russia, Moсква, Russia
      name:People’s Friendship University of Russia, Moсква, Russia
      name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
      name:People’s Friendship University of Russia, Moсква, Russia
      name:N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
      name:People’s Friendship University of Russia, Moсква, Russia
      name:People’s Friendship University of Russia, Moсква, Russia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(79)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.79s.

LINK . SPRINGER . COM {}