We are analyzing https://link.springer.com/article/10.1007/s10495-014-0988-x.

Title:
Resveratrol-induced potentiation of the antitumor effects of oxaliplatin is accompanied by an altered cytokine profile of human monocyte-derived macrophages | Apoptosis
Description:
The objective of this study was to investigate, whether the naturally occurring polyphenol resveratrol (Res) enhances the anti-tumor activities of the chemotherapeutic agent oxaliplatin (Ox) in a cell culture model of colorectal cancer, also with regard to a possible inflammatory response and cytotoxic side-effects. Res and Ox in combination synergistically inhibit cell growth of Caco-2 cells, which seems to be due to the induction of different modes of cell death and further leads to an altered cytokine profile of cocultured macrophages. Moreover, combinatorial treatment does not affect non-transformed cells as severe cytotoxicity is not detected in human foreskin fibroblasts and platelets.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, cell, resveratrol, apoptosis, cells, macrophages, human, res, death, oxaliplatin, central, effects, survivin, tumor, kaminski, rev, main, antitumor, stein, colorectal, therapy, mol, nutr, nat, immunol, role, anticancer, frankfurt, privacy, cookies, content, weigert, enhances, access, lines, molecular, apoptotic, int, activity, biol, progression, van, publish, research, search,

Topics {✒️}

tgf-beta/smad signaling pathway month download article/chapter drug-resistant cell lines cell culture model human monocyte-derived macrophages max-von-laue-str caspase-independent cell death briaire-de bruijn ih sandra ulrich-rückert colorectal carcinoma cells immunogenic death colorectal cancer cells enhances paclitaxel-induced apoptosis resveratrol-induced potentiation cancer-related inflammation cell death inhibition full article pdf related subjects andreas weigert altered cytokine profile article apoptosis aims kerstin brecht & bernhard brüne colon cancer cells neuronal death mediated tumor cell migration privacy choices/manage cookies human foreskin fibroblasts apoptotic regulatory proteins concurrent atp deficiency c-reactive protein anti-cancer therapy human pancreatic cancer primary human fibroblasts paclitaxel-induced apoptosis cell cycle progression ifn-gamma attenuates cell cycle arrest resveratrol-mediated reversal primary human adipocytes anti-tumor activities radiation-induced apoptosis macrophages tnf-α colorectal cancer p-glycoprotein inhibition graduate scholarship grants instant access pro-apoptotic effects resveratrol synergistically enhances cell lines molecularly targeted therapy

Questions {❓}

Vang O, Ahmad N, Baile CA, Baur JA, Brown K, Csiszar A, Das DK, Delmas D, Gottfried C, Lin HY, Ma QY, Mukhopadhyay P, Nalini N, Pezzuto JM, Richard T, Shukla Y, Surh YJ, Szekeres T, Szkudelski T, Walle T, Wu JM (2011) What is new for an old molecule?

Schema {🗺️}

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      headline:Resveratrol-induced potentiation of the antitumor effects of oxaliplatin is accompanied by an altered cytokine profile of human monocyte-derived macrophages
      description:The objective of this study was to investigate, whether the naturally occurring polyphenol resveratrol (Res) enhances the anti-tumor activities of the chemotherapeutic agent oxaliplatin (Ox) in a cell culture model of colorectal cancer, also with regard to a possible inflammatory response and cytotoxic side-effects. Res and Ox in combination synergistically inhibit cell growth of Caco-2 cells, which seems to be due to the induction of different modes of cell death and further leads to an altered cytokine profile of cocultured macrophages. Moreover, combinatorial treatment does not affect non-transformed cells as severe cytotoxicity is not detected in human foreskin fibroblasts and platelets.
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         Oxaliplatin
         Colorectal cancer
         Immunogenic cell death
         Cell culture
         Cancer Research
         Cell Biology
         Oncology
         Biochemistry
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         Virology
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