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Title:
Apoptosis-inducing factor (AIF) and leukocyte elastase inhibitor/l-DNase II (LEI/LDNaseII), can interact to conduct caspase-independent cell death | Apoptosis
Description:
Programmed cell death is an important factor in tissue homeostasis. Lot of work has been performed to characterize the caspase-dependent cell death. Caspase-independent cell death, although important in many physiological situations, is less investigated. In this work we show that two caspase-independent effectors of cell death, namely apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death. These results contribute to the knowledge of molecular pathways of cell death, an important issue in the development of new therapeutic strategies for the treatment of cancer or neurodegenerative diseases.
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Keywords {🔍}
article, pubmed, google, scholar, cas, cell, torriglia, apoptosis, death, factor, apoptosisinducing, biol, caspaseindependent, aif, leukocyte, elastase, courtois, inhibitor, cells, pathway, ldnase, counis, leprêtre, tchakarska, susin, nuclear, exp, paris, privacy, cookies, content, chloé, guergana, blibech, alicia, programmed, dnase, molecular, access, mitochondrial, nature, mol, human, lepretre, int, apoptotic, france, publish, search, hounayda,
Topics {✒️}
aif-mediated caspase-independent necroptosis lei/l-dnase ii pathway apoptotic chromatin condensation aif-mediated programmed necrosis caspase-independent cell death l-dnase ii activation month download article/chapter apoptosis-inducing factor leads regulates apoptosis-inducing factor apoptosis-inducing factor substitutes dna degradation caspase-dependent cell death somato-lactotrope pituitary cells caspase-3-dependent signaling pathways egf-induced cell death caspase-3-activated protein required caspase-independent aif/endo c-myc expression level light-induced retinal degeneration mitochondrial apoptosis-inducing factor l-dnase ii leukocyte elastase inhibitor caspase-independent apoptosis nuclear-mitochondrial cross-talk programmed cell death caspase-activated dnase apoptosis-inducing factor caspase-independent effectors article apoptosis aims endoplasmic reticulum stress full article pdf human deoxyribonuclease ii induce cell death cell death subroutines privacy choices/manage cookies human leukemia cells related subjects 24 kda apoptotic protease staurosporine-induced apoptosis tnfalpha-induced apoptosis cell cycle 6 cell cycle 9 endonuclease involved acute graft rejection dnase ii lens cell differentiation mitochondrial signaling pathway caspase-independent harlequin mouse mutation +antiport inhibition activates
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headline:Apoptosis-inducing factor (AIF) and leukocyte elastase inhibitor/l-DNase II (LEI/LDNaseII), can interact to conduct caspase-independent cell death
description:Programmed cell death is an important factor in tissue homeostasis. Lot of work has been performed to characterize the caspase-dependent cell death. Caspase-independent cell death, although important in many physiological situations, is less investigated. In this work we show that two caspase-independent effectors of cell death, namely apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death. These results contribute to the knowledge of molecular pathways of cell death, an important issue in the development of new therapeutic strategies for the treatment of cancer or neurodegenerative diseases.
datePublished:2013-05-15T00:00:00Z
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AIF
l-DNase II
Apoptosis
DNA degradation
Chromatin condensation
Endonuclease
Caspase-independent
Cancer Research
Cell Biology
Oncology
Biochemistry
general
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headline:Apoptosis-inducing factor (AIF) and leukocyte elastase inhibitor/l-DNase II (LEI/LDNaseII), can interact to conduct caspase-independent cell death
description:Programmed cell death is an important factor in tissue homeostasis. Lot of work has been performed to characterize the caspase-dependent cell death. Caspase-independent cell death, although important in many physiological situations, is less investigated. In this work we show that two caspase-independent effectors of cell death, namely apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death. These results contribute to the knowledge of molecular pathways of cell death, an important issue in the development of new therapeutic strategies for the treatment of cancer or neurodegenerative diseases.
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l-DNase II
Apoptosis
DNA degradation
Chromatin condensation
Endonuclease
Caspase-independent
Cancer Research
Cell Biology
Oncology
Biochemistry
general
Virology
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